Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /DUF1778(antitoxin) |
| Location | 363473..364323 | Replicon | chromosome |
| Accession | NZ_CP016325 | ||
| Organism | Vibrio cholerae 2740-80 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | Q9KM94 |
| Locus tag | BBB50_RS15635 | Protein ID | WP_000118351.1 |
| Coordinates | 363790..364323 (+) | Length | 178 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | - |
| Locus tag | BBB50_RS15630 | Protein ID | WP_001909340.1 |
| Coordinates | 363473..363793 (+) | Length | 107 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| BBB50_RS15600 | 358809..359291 | + | 483 | WP_000422940.1 | GNAT family N-acetyltransferase | - |
| BBB50_RS15610 | 360099..360368 | + | 270 | WP_001114075.1 | DUF4160 domain-containing protein | - |
| BBB50_RS15615 | 360362..360883 | + | 522 | WP_000921692.1 | DUF2442 domain-containing protein | - |
| BBB50_RS19695 | 360940..361053 | + | 114 | WP_001894981.1 | hypothetical protein | - |
| BBB50_RS15620 | 361022..361858 | + | 837 | WP_000242986.1 | hypothetical protein | - |
| BBB50_RS15625 | 362023..362661 | + | 639 | WP_000230118.1 | HD domain-containing protein | - |
| BBB50_RS20245 | 362751..362911 | + | 161 | Protein_340 | DUF3709 domain-containing protein | - |
| BBB50_RS19700 | 362932..363153 | + | 222 | WP_012705854.1 | DUF3709 domain-containing protein | - |
| BBB50_RS15630 | 363473..363793 | + | 321 | WP_001909340.1 | DUF1778 domain-containing protein | Antitoxin |
| BBB50_RS15635 | 363790..364323 | + | 534 | WP_000118351.1 | GNAT family N-acetyltransferase | Toxin |
| BBB50_RS15640 | 364561..364839 | + | 279 | WP_000280324.1 | DUF3709 domain-containing protein | - |
| BBB50_RS20480 | 365214..365357 | + | 144 | Protein_345 | DUF645 family protein | - |
| BBB50_RS20485 | 365411..365449 | + | 39 | WP_082798268.1 | hypothetical protein | - |
| BBB50_RS15645 | 365661..366128 | + | 468 | WP_001289288.1 | OsmC family protein | - |
| BBB50_RS15650 | 366256..366918 | + | 663 | WP_000960654.1 | hypothetical protein | - |
| BBB50_RS15655 | 367103..367369 | + | 267 | WP_000589156.1 | BrnT family toxin | - |
| BBB50_RS15660 | 367356..367601 | + | 246 | WP_000643598.1 | hypothetical protein | - |
| BBB50_RS15665 | 367697..368491 | + | 795 | WP_001911581.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 304243..451810 | 147567 | |
| - | inside | Integron | - | - | 309323..451434 | 142111 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 178 a.a. Molecular weight: 20171.46 Da Isoelectric Point: 9.1432
>T64434 WP_000118351.1 NZ_CP016325:363790-364323 [Vibrio cholerae 2740-80]
VSWGKEFVELSKSKHDRDSFDCGEQELNTFIKTQAAKHMQAGISRTMVLPSAHPLLNQKFAICAFYSVAPSSISRETLPA
QLAKKLPRYPIPVFLLAQLAVHKEFHGSGLGKVSLIRALKYLWEVNHHMRAYAIVVDCLTDSAQAFYTKFGFEVLCEHNE
RIRMFLPMKTVEQLFNQ
VSWGKEFVELSKSKHDRDSFDCGEQELNTFIKTQAAKHMQAGISRTMVLPSAHPLLNQKFAICAFYSVAPSSISRETLPA
QLAKKLPRYPIPVFLLAQLAVHKEFHGSGLGKVSLIRALKYLWEVNHHMRAYAIVVDCLTDSAQAFYTKFGFEVLCEHNE
RIRMFLPMKTVEQLFNQ
Download Length: 534 bp
>T64434 NZ_CP016325:363790-364323 [Vibrio cholerae 2740-80]
GTGAGTTGGGGCAAAGAGTTTGTAGAACTTAGTAAATCAAAGCATGACCGCGACTCATTTGACTGTGGTGAGCAAGAGCT
AAACACATTTATCAAAACTCAAGCTGCAAAGCACATGCAAGCAGGTATTAGTCGAACAATGGTTTTACCTAGTGCTCACC
CACTGTTAAATCAAAAATTCGCTATTTGTGCCTTTTATAGTGTTGCACCGAGCTCAATCAGCCGAGAAACATTACCGGCA
CAATTAGCAAAGAAACTACCGAGGTATCCAATCCCTGTTTTTCTGTTGGCTCAGTTAGCTGTGCACAAAGAATTTCACGG
TTCTGGACTTGGAAAGGTCAGTCTAATCCGTGCGCTGAAGTACTTGTGGGAAGTGAATCATCACATGAGAGCATATGCAA
TAGTTGTGGATTGTCTGACAGATTCCGCTCAAGCGTTCTATACGAAGTTCGGCTTTGAAGTATTGTGCGAACATAATGAG
CGTATTCGTATGTTCTTACCGATGAAAACGGTAGAACAACTTTTTAATCAATAG
GTGAGTTGGGGCAAAGAGTTTGTAGAACTTAGTAAATCAAAGCATGACCGCGACTCATTTGACTGTGGTGAGCAAGAGCT
AAACACATTTATCAAAACTCAAGCTGCAAAGCACATGCAAGCAGGTATTAGTCGAACAATGGTTTTACCTAGTGCTCACC
CACTGTTAAATCAAAAATTCGCTATTTGTGCCTTTTATAGTGTTGCACCGAGCTCAATCAGCCGAGAAACATTACCGGCA
CAATTAGCAAAGAAACTACCGAGGTATCCAATCCCTGTTTTTCTGTTGGCTCAGTTAGCTGTGCACAAAGAATTTCACGG
TTCTGGACTTGGAAAGGTCAGTCTAATCCGTGCGCTGAAGTACTTGTGGGAAGTGAATCATCACATGAGAGCATATGCAA
TAGTTGTGGATTGTCTGACAGATTCCGCTCAAGCGTTCTATACGAAGTTCGGCTTTGAAGTATTGTGCGAACATAATGAG
CGTATTCGTATGTTCTTACCGATGAAAACGGTAGAACAACTTTTTAATCAATAG
Antitoxin
Download Length: 107 a.a. Molecular weight: 11759.53 Da Isoelectric Point: 4.9309
>AT64434 WP_001909340.1 NZ_CP016325:363473-363793 [Vibrio cholerae 2740-80]
MAYNRSTDGMYPYAGGVMATARLDIRLDEEIKAKAEKASALLGLKSLTEYVVRLMDEDATHVIEEHESIMVKDSVFDEFM
AACNKVKAPNQALLEAVKFTEKSGIK
MAYNRSTDGMYPYAGGVMATARLDIRLDEEIKAKAEKASALLGLKSLTEYVVRLMDEDATHVIEEHESIMVKDSVFDEFM
AACNKVKAPNQALLEAVKFTEKSGIK
Download Length: 321 bp
>AT64434 NZ_CP016325:363473-363793 [Vibrio cholerae 2740-80]
TTGGCCTATAATCGCTCAACTGACGGAATGTATCCGTACGCAGGAGGGGTTATGGCAACGGCACGTTTAGATATCCGCCT
TGATGAAGAGATCAAGGCAAAAGCCGAAAAGGCATCGGCTTTACTTGGTTTAAAAAGTCTCACTGAATATGTGGTGAGAC
TTATGGACGAAGATGCGACTCATGTTATTGAGGAGCATGAAAGTATTATGGTTAAAGACAGTGTTTTTGACGAGTTTATG
GCTGCGTGTAATAAAGTAAAAGCACCGAATCAAGCTTTGCTTGAAGCTGTTAAATTTACAGAGAAGAGCGGTATCAAGTG
A
TTGGCCTATAATCGCTCAACTGACGGAATGTATCCGTACGCAGGAGGGGTTATGGCAACGGCACGTTTAGATATCCGCCT
TGATGAAGAGATCAAGGCAAAAGCCGAAAAGGCATCGGCTTTACTTGGTTTAAAAAGTCTCACTGAATATGTGGTGAGAC
TTATGGACGAAGATGCGACTCATGTTATTGAGGAGCATGAAAGTATTATGGTTAAAGACAGTGTTTTTGACGAGTTTATG
GCTGCGTGTAATAAAGTAAAAGCACCGAATCAAGCTTTGCTTGAAGCTGTTAAATTTACAGAGAAGAGCGGTATCAAGTG
A
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|