64433

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DhiAT/-
Location 360099..360883 Replicon chromosome
Accession NZ_CP016325
Organism Vibrio cholerae 2740-80

Toxin (Protein)


Gene name dhiT Uniprot ID A0A086SLD6
Locus tag BBB50_RS15610 Protein ID WP_001114075.1
Coordinates 360099..360368 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name dhiA Uniprot ID C3LUY7
Locus tag BBB50_RS15615 Protein ID WP_000921692.1
Coordinates 360362..360883 (+) Length 174 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BBB50_RS19665 355548..355649 + 102 WP_079993098.1 DUF3265 domain-containing protein -
BBB50_RS15585 355817..355999 + 183 WP_000923182.1 DUF645 family protein -
BBB50_RS15590 356215..357219 + 1005 WP_000964920.1 LD-carboxypeptidase -
BBB50_RS15595 357793..358221 + 429 WP_000620002.1 N-acetyltransferase -
BBB50_RS15600 358809..359291 + 483 WP_000422940.1 GNAT family N-acetyltransferase -
BBB50_RS15610 360099..360368 + 270 WP_001114075.1 DUF4160 domain-containing protein Toxin
BBB50_RS15615 360362..360883 + 522 WP_000921692.1 DUF2442 domain-containing protein Antitoxin
BBB50_RS19695 360940..361053 + 114 WP_001894981.1 hypothetical protein -
BBB50_RS15620 361022..361858 + 837 WP_000242986.1 hypothetical protein -
BBB50_RS15625 362023..362661 + 639 WP_000230118.1 HD domain-containing protein -
BBB50_RS20245 362751..362911 + 161 Protein_340 DUF3709 domain-containing protein -
BBB50_RS19700 362932..363153 + 222 WP_012705854.1 DUF3709 domain-containing protein -
BBB50_RS15630 363473..363793 + 321 WP_001909340.1 DUF1778 domain-containing protein -
BBB50_RS15635 363790..364323 + 534 WP_000118351.1 GNAT family N-acetyltransferase -
BBB50_RS15640 364561..364839 + 279 WP_000280324.1 DUF3709 domain-containing protein -
BBB50_RS20480 365214..365357 + 144 Protein_345 DUF645 family protein -
BBB50_RS20485 365411..365449 + 39 WP_082798268.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 304243..451810 147567
- inside Integron - - 309323..451434 142111


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF4160

(9-74)

Antitoxin

Protein of unknown function DUF2442

(4-59)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10310.94 Da        Isoelectric Point: 6.6303

>T64433 WP_001114075.1 NZ_CP016325:360099-360368 [Vibrio cholerae 2740-80]
MPEIDALLGLSFCLYFFDNKQHKLPHIHVKYGSYELIIAIETGECLEGYLPNKQRKRAENHILEHREQLMVMWNKAVNGE
NPGKLGDLC

Download         Length: 270 bp

>T64433 NZ_CP016325:360099-360368 [Vibrio cholerae 2740-80]
ATGCCAGAGATTGATGCCCTATTAGGCCTTTCATTTTGCTTGTACTTCTTTGATAACAAGCAGCATAAATTGCCTCATAT
TCACGTTAAGTACGGTAGTTACGAGCTAATTATTGCTATTGAAACAGGTGAGTGTTTAGAGGGTTACTTACCCAATAAAC
AACGAAAACGTGCTGAAAACCATATTCTTGAACATCGAGAGCAATTGATGGTGATGTGGAATAAAGCGGTGAATGGTGAA
AATCCAGGTAAGTTAGGTGATTTATGTTGA

Antitoxin


Download         Length: 174 a.a.        Molecular weight: 19439.04 Da        Isoelectric Point: 6.7342

>AT64433 WP_000921692.1 NZ_CP016325:360362-360883 [Vibrio cholerae 2740-80]
MLKVIDVDFVSDHTLELTFNDGYQGYADLSVYFKKTPFSEIKDFKRFSLTRDGSLNWDGNELTAATLRDITKGSQKSVEL
SFNVQEMEAVIKQASWESMMEGRPDILQAAIRSYVEQFGHGQVIAKAGIKSRTSAYRSLKPETTPNFGTLVQLGHAVIEL
AKDRTVANKEPRI

Download         Length: 522 bp

>AT64433 NZ_CP016325:360362-360883 [Vibrio cholerae 2740-80]
ATGTTGAAAGTCATAGATGTTGATTTTGTCTCAGACCATACATTAGAACTGACGTTCAATGATGGTTACCAAGGCTATGC
CGACTTGTCGGTATACTTTAAAAAAACACCGTTTTCAGAAATTAAGGACTTTAAACGCTTTTCCTTGACTCGTGATGGCT
CGTTAAATTGGGATGGTAATGAGTTAACGGCCGCGACACTCCGTGACATAACCAAGGGCTCACAAAAGTCGGTGGAGTTA
AGTTTTAATGTTCAAGAAATGGAAGCCGTCATCAAACAGGCCTCATGGGAATCGATGATGGAGGGGCGTCCCGACATCTT
GCAAGCGGCTATTCGTTCTTACGTAGAGCAGTTTGGTCATGGTCAAGTTATTGCAAAGGCGGGTATAAAAAGTCGTACGA
GTGCTTATCGCTCCTTGAAGCCAGAAACAACGCCAAACTTTGGCACACTAGTTCAGTTAGGGCACGCCGTCATCGAACTA
GCGAAAGATAGAACAGTGGCAAACAAGGAACCACGCATATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A086SLD6

Antitoxin

Source ID Structure
AlphaFold DB C3LUY7

References