Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PanAT/DUF4065(antitoxin)
Location 3045916..3047603 Replicon chromosome
Accession NZ_CP016321
Organism Vibrio vulnificus strain FORC_037

Toxin (Protein)


Gene name panT Uniprot ID -
Locus tag FORC37_RS14965 Protein ID WP_088428166.1
Coordinates 3045916..3047139 (-) Length 408 a.a.

Antitoxin (Protein)


Gene name panA Uniprot ID -
Locus tag FORC37_RS14970 Protein ID WP_088428167.1
Coordinates 3047136..3047603 (-) Length 156 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FORC37_RS14950 3041644..3042327 - 684 WP_198300250.1 adenine nucleotide alpha hydrolase -
FORC37_RS14955 3042372..3044213 - 1842 WP_088428164.1 TonB-dependent receptor -
FORC37_RS14960 3044616..3045725 + 1110 WP_088428165.1 tRNA (uridine(54)-C5)-methyltransferase TrmA -
FORC37_RS14965 3045916..3047139 - 1224 WP_088428166.1 RelA/SpoT domain-containing protein Toxin
FORC37_RS14970 3047136..3047603 - 468 WP_088428167.1 DUF4065 domain-containing protein Antitoxin
FORC37_RS14975 3047857..3048528 - 672 WP_088428168.1 hypothetical protein -
FORC37_RS14980 3048673..3049710 + 1038 WP_088428169.1 helix-turn-helix domain-containing protein -
FORC37_RS14985 3049877..3050518 + 642 WP_088428170.1 inovirus Gp2 family protein -
FORC37_RS14990 3050559..3051005 - 447 WP_088428171.1 hypothetical protein -
FORC37_RS14995 3051116..3052105 - 990 WP_088428172.1 50S ribosome-binding GTPase -
FORC37_RS15000 3052183..3052404 + 222 WP_088428173.1 AlpA family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RelA/SpoT

(111-228)

Antitoxin

Antitoxin SocA-like, Panacea domain

(32-123)


Sequences

Toxin        


Download         Length: 408 a.a.        Molecular weight: 45948.67 Da        Isoelectric Point: 5.1409

>T64427 WP_088428166.1 NZ_CP016321:c3047139-3045916 [Vibrio vulnificus]
VSDKENSVVSFYIDDTPTAEQASKTFQDDYELDFQDFIERTVNESAAEDFSYSNNGVKKAGRRLRKREGDLKSATATIQQ
FRAAHEKPLNTIAYLVGRCCRELGIDVKPVTRLKRLETIVDKLQRKSLDGETANATCVTNMNDIGGCRAIFPDLISLEKV
QSQLQLTVEKVGRVRIKDIDDYITSPKPNDCGYRSLHVIYRYDHASGKSFNIEAQLRTRLQHLWATTVEIVDILEGTKIK
THSHSSNEDKSSLQIQWEELLSIMSQYIADAEGAIELSDIDKANFSKRLIVLDREINALNRLSSFKILSEKVNSCCDNSI
EHVLLVINETSRELIFSEEFENYSQAISVYNAAEKVTRSYSRSTSRLNTLLISTKNMGQLSEAYPNYLGDCASFITLLED
AMLSGES

Download         Length: 1224 bp

>T64427 NZ_CP016321:c3047139-3045916 [Vibrio vulnificus]
GTGAGTGACAAAGAAAATAGTGTTGTCAGTTTTTACATTGACGACACTCCTACCGCAGAACAAGCTTCAAAAACCTTCCA
AGACGACTACGAGCTGGACTTTCAAGATTTTATAGAAAGAACGGTAAATGAAAGTGCTGCTGAAGACTTCTCGTACTCAA
ATAATGGAGTAAAGAAAGCTGGAAGACGGCTGCGCAAGAGAGAGGGCGACCTCAAGTCAGCTACTGCTACAATCCAACAG
TTTCGAGCCGCACACGAAAAGCCATTAAACACTATCGCATATCTTGTTGGTCGCTGTTGCCGGGAACTGGGTATAGATGT
AAAACCAGTTACACGGTTAAAGCGTTTAGAAACAATCGTAGATAAGTTGCAGCGTAAATCTCTTGATGGTGAAACGGCAA
ATGCTACTTGTGTGACCAATATGAATGATATTGGCGGTTGCAGGGCGATTTTCCCGGATTTAATTTCCTTGGAGAAGGTG
CAATCTCAACTGCAACTTACCGTTGAAAAGGTAGGTCGAGTTAGAATCAAAGATATTGACGATTATATTACTAGCCCTAA
GCCTAATGATTGTGGTTACCGAAGCTTGCATGTAATTTATCGCTATGACCATGCTAGCGGTAAAAGTTTTAACATTGAGG
CTCAGCTACGTACTCGACTTCAACATCTTTGGGCAACTACTGTGGAAATTGTCGACATCCTGGAAGGCACCAAGATTAAG
ACTCACTCTCACAGTTCAAATGAAGATAAGAGTAGTTTACAGATTCAATGGGAAGAATTGCTTTCGATCATGAGCCAGTA
CATTGCTGATGCTGAAGGGGCTATAGAGCTAAGTGATATCGATAAAGCCAATTTTTCAAAGCGCTTGATCGTCTTGGACC
GCGAAATCAATGCGCTGAATCGATTGAGTAGTTTTAAAATTTTATCTGAAAAGGTGAATTCTTGCTGTGATAACTCTATT
GAGCACGTATTGCTAGTTATTAACGAAACCTCACGAGAATTGATCTTTAGTGAAGAGTTTGAAAATTACAGTCAGGCAAT
TTCAGTTTACAACGCGGCTGAGAAAGTCACTCGTAGCTACTCAAGATCAACCTCGAGACTCAATACCCTTCTCATCTCCA
CAAAAAATATGGGGCAACTTTCGGAAGCCTACCCTAACTATCTAGGTGATTGTGCCTCATTCATCACTCTGCTTGAAGAC
GCAATGCTTTCTGGTGAAAGTTAA

Antitoxin


Download         Length: 156 a.a.        Molecular weight: 17531.00 Da        Isoelectric Point: 7.9061

>AT64427 WP_088428167.1 NZ_CP016321:c3047603-3047136 [Vibrio vulnificus]
MKAYHTYSAVDVAWSLLKHAKEQGKCFSNLQLQKLTYVCHGLSLAHFQRPLVVDDVFAWKFGPVVPSVYFRFKSYGSSVI
TEQCDIALDQESESLVKDVVSKLGHLTGPQLVDLTHREGSPWHQVWDGTHQKVIPDHLIQAHYTQIKQSGRTASL

Download         Length: 468 bp

>AT64427 NZ_CP016321:c3047603-3047136 [Vibrio vulnificus]
ATGAAAGCATATCACACATACAGTGCTGTAGACGTTGCATGGAGCTTGCTCAAGCATGCGAAAGAGCAAGGTAAATGCTT
CTCCAATTTGCAGCTACAAAAACTTACCTATGTTTGTCATGGTTTATCATTGGCGCATTTCCAGCGTCCTCTCGTCGTAG
ATGATGTATTTGCTTGGAAGTTTGGTCCAGTGGTGCCATCTGTTTACTTCCGCTTTAAATCTTACGGTAGTAGTGTGATC
ACTGAACAATGTGATATAGCACTAGACCAAGAAAGTGAGTCTCTTGTCAAAGATGTTGTATCTAAACTGGGCCATTTGAC
GGGGCCTCAACTTGTAGATTTAACTCACCGAGAGGGAAGTCCATGGCATCAGGTATGGGATGGCACACACCAAAAAGTGA
TTCCGGATCATTTGATTCAAGCCCATTACACTCAAATCAAACAATCCGGACGAACAGCTAGCCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References