Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 1737064..1737623 Replicon chromosome
Accession NZ_CP016321
Organism Vibrio vulnificus strain FORC_037

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag FORC37_RS08820 Protein ID WP_025594774.1
Coordinates 1737345..1737623 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag FORC37_RS08815 Protein ID WP_088427830.1
Coordinates 1737064..1737348 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FORC37_RS08770 1732601..1733014 - 414 WP_005526689.1 VOC family protein -
FORC37_RS08775 1733204..1733569 - 366 WP_088427826.1 hypothetical protein -
FORC37_RS08780 1733594..1733728 - 135 WP_198300276.1 DUF3265 domain-containing protein -
FORC37_RS08790 1734219..1734695 - 477 WP_039542997.1 hypothetical protein -
FORC37_RS08795 1734887..1735855 + 969 WP_088427742.1 IS30-like element ISVvu6 family transposase -
FORC37_RS08800 1735881..1736240 - 360 WP_088427828.1 VOC family protein -
FORC37_RS08805 1736286..1736375 - 90 WP_072606010.1 DUF3265 domain-containing protein -
FORC37_RS24475 1736504..1736863 + 360 WP_198300231.1 hypothetical protein -
FORC37_RS08815 1737064..1737348 + 285 WP_088427830.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
FORC37_RS08820 1737345..1737623 + 279 WP_025594774.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
FORC37_RS08825 1737652..1737762 - 111 WP_080765049.1 DUF3265 domain-containing protein -
FORC37_RS08830 1737778..1738194 - 417 WP_088427831.1 DUF1311 domain-containing protein -
FORC37_RS08835 1738224..1738316 - 93 WP_017420683.1 DUF3265 domain-containing protein -
FORC37_RS08840 1738349..1738696 - 348 WP_017036770.1 DUF3024 domain-containing protein -
FORC37_RS08845 1739339..1739431 - 93 WP_196298091.1 DUF3265 domain-containing protein -
FORC37_RS08850 1739466..1739774 - 309 WP_045372057.1 hypothetical protein -
FORC37_RS08855 1739803..1739928 - 126 WP_088427832.1 DUF3265 domain-containing protein -
FORC37_RS08860 1739919..1740263 - 345 WP_088427833.1 hypothetical protein -
FORC37_RS08865 1740398..1741348 - 951 WP_088427834.1 hypothetical protein -
FORC37_RS08870 1741385..1741474 - 90 WP_198300277.1 DUF3265 domain-containing protein -
FORC37_RS08875 1741500..1741877 - 378 WP_088427835.1 hypothetical protein -
FORC37_RS08880 1741874..1742014 - 141 WP_088427836.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1624817..1757381 132564
- flank IS/Tn - - 1734887..1735855 968
- inside Integron - - 1630666..1757381 126715


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(1-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10940.65 Da        Isoelectric Point: 4.3430

>T64426 WP_025594774.1 NZ_CP016321:1737345-1737623 [Vibrio vulnificus]
MILWEEESLNDREKIFEFLYDFNPDAAEKTDYLIEAKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWVEGDIIRVM
RVLHQKQKFPTD

Download         Length: 279 bp

>T64426 NZ_CP016321:1737345-1737623 [Vibrio vulnificus]
ATGATTTTATGGGAAGAAGAGTCACTTAATGATCGTGAAAAGATCTTCGAGTTTCTCTATGACTTCAACCCTGATGCGGC
AGAAAAGACTGACTACCTCATTGAAGCAAAAGTAGAAAACTTGCTTGAACAACCTTTGATGGGTGTACAACGAGATGGTA
TCCGCGGACGATTGCTCATTATTCCTGAGATTTCGATGATTGTCTCTTACTGGGTCGAGGGCGATATCATCCGTGTTATG
CGTGTACTCCACCAGAAACAAAAATTCCCTACAGATTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 11055.37 Da        Isoelectric Point: 9.2167

>AT64426 WP_088427830.1 NZ_CP016321:1737064-1737348 [Vibrio vulnificus]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQVNLAFEKFDSGKSVFVEHQSAKSR
MEERKARIRNRGKQ

Download         Length: 285 bp

>AT64426 NZ_CP016321:1737064-1737348 [Vibrio vulnificus]
ATGGACACTAGAATTCAATTTCGTGTTGATGAAGAAACAAAACGCCTAGCTCAACAAATGGCTGAGAGCCAAGGTCGCAC
TCTTAGTGACGCATGCCGTGAACTTACTGAGCAACTCGCTGAACAACAAAGAAAAACATTGTCTCACGATGCATGGCTAA
CTGAACAAGTAAATCTAGCATTTGAGAAGTTTGACTCAGGAAAGTCCGTTTTCGTTGAGCACCAATCTGCTAAATCTCGA
ATGGAAGAGCGTAAAGCCAGAATCCGTAATCGAGGTAAACAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References