Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 1697672..1698438 Replicon chromosome
Accession NZ_CP016321
Organism Vibrio vulnificus strain FORC_037

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag FORC37_RS08330 Protein ID WP_053809335.1
Coordinates 1697941..1698438 (+) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag FORC37_RS08325 Protein ID WP_088427794.1
Coordinates 1697672..1697944 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FORC37_RS08280 1693570..1694016 - 447 WP_088427788.1 hypothetical protein -
FORC37_RS08285 1694013..1694162 - 150 WP_088427789.1 DUF3265 domain-containing protein -
FORC37_RS08295 1694645..1695106 - 462 WP_025633769.1 RidA family protein -
FORC37_RS24455 1695039..1695266 - 228 WP_088427791.1 DUF3265 domain-containing protein -
FORC37_RS08305 1695728..1696153 - 426 WP_038940647.1 hypothetical protein -
FORC37_RS08310 1696174..1696305 - 132 WP_088427792.1 DUF3265 domain-containing protein -
FORC37_RS08315 1696775..1697440 - 666 WP_088427793.1 hypothetical protein -
FORC37_RS24460 1697470..1697562 - 93 WP_196333399.1 DUF3265 domain-containing protein -
FORC37_RS08325 1697672..1697944 + 273 WP_088427794.1 DUF1778 domain-containing protein Antitoxin
FORC37_RS08330 1697941..1698438 + 498 WP_053809335.1 GNAT family N-acetyltransferase Toxin
FORC37_RS08335 1698581..1699012 - 432 WP_045590852.1 NUDIX domain-containing protein -
FORC37_RS24465 1699041..1699130 - 90 WP_140244931.1 DUF3265 domain-containing protein -
FORC37_RS08345 1699248..1700216 + 969 WP_076611600.1 IS30-like element ISVvu6 family transposase -
FORC37_RS08350 1700257..1700586 - 330 WP_026050567.1 hypothetical protein -
FORC37_RS08355 1700579..1700743 - 165 WP_088427796.1 DUF3265 domain-containing protein -
FORC37_RS08360 1701074..1701202 - 129 WP_088428253.1 DUF3265 domain-containing protein -
FORC37_RS08365 1701516..1701668 - 153 WP_088427797.1 DUF3265 domain-containing protein -
FORC37_RS08375 1702027..1702128 - 102 WP_088428254.1 DUF3265 domain-containing protein -
FORC37_RS08385 1702511..1702633 - 123 WP_086467490.1 DUF3265 domain-containing protein -
FORC37_RS08390 1702991..1703083 - 93 WP_080254084.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1624817..1757381 132564
- flank IS/Tn - - 1692570..1693538 968
- flank IS/Tn - - 1699248..1700216 968
- inside Integron - - 1630666..1757381 126715


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18484.15 Da        Isoelectric Point: 8.7753

>T64425 WP_053809335.1 NZ_CP016321:1697941-1698438 [Vibrio vulnificus]
MMNTVLLDKAKHDRNRFNCGIEALNNYLKVMASQQAKKDNTRTFVLEDDSDNSHVIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKYFYERYGFQAFQDAENKLFITIADV
RASLG

Download         Length: 498 bp

>T64425 NZ_CP016321:1697941-1698438 [Vibrio vulnificus]
ATGATGAATACGGTACTTCTAGATAAAGCTAAACACGATAGAAACCGATTCAACTGTGGCATCGAAGCTCTCAATAATTA
CTTAAAAGTAATGGCGAGTCAGCAAGCAAAGAAGGACAACACCAGAACGTTTGTTTTGGAAGATGATAGCGACAACTCAC
ATGTCATCGGCTTTTACACGCTAACAATGACACCAATTGACTTAAAGGCATTGCCTGATAAGTTACAAAAAAAGCACCAA
TCATCCACCTCTGGTGGTCTGATTGCCCGTCTTGCTGTCGATGACCGATACAAAGGGAAAGGCTTTGGTGAGTGGCTGCT
TATCGACGCACTCAGAAAGCTATTAGCCGCTAGTGATAGCGTCGCATTTCCAGTTGTTATCGTTGATGCCAAAGACGGAG
CAAAATATTTCTATGAACGCTATGGTTTTCAAGCATTTCAAGACGCTGAAAACAAACTCTTCATCACCATTGCAGATGTG
AGAGCAAGCTTAGGCTAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9726.19 Da        Isoelectric Point: 6.2901

>AT64425 WP_088427794.1 NZ_CP016321:1697672-1697944 [Vibrio vulnificus]
MATTLPRITARVDVDTQDLLTKAAAIAGMSSINSFVLSAAIEKAKQVIEREQALKLSQADAMMLMEALDRPATQNSKLKA
AADRYESTTQ

Download         Length: 273 bp

>AT64425 NZ_CP016321:1697672-1697944 [Vibrio vulnificus]
ATGGCTACTACTTTGCCTCGCATCACCGCTAGAGTTGATGTCGATACACAAGACTTACTTACTAAGGCTGCCGCGATCGC
CGGCATGTCTAGCATCAACTCGTTTGTTCTAAGCGCTGCAATCGAAAAAGCTAAACAAGTCATCGAACGTGAACAGGCTT
TAAAACTGAGCCAAGCTGATGCGATGATGCTTATGGAAGCTTTAGACCGTCCTGCAACACAGAACTCAAAACTAAAAGCT
GCTGCTGATCGATACGAGAGCACAACTCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References