Detailed information of TA system TA064398

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /SpoIISA(toxin)
• Location: 2391840..2392813
• Replicon: chromosome
• Accession: NZ_CP016316
• Organism: Bacillus cereus strain M3

Toxin (Protein)

• Gene name: spoIISA
• Uniprot ID: -
• Locus tag: BA202_RS12590
• Protein ID: WP_014893739.1
• Coordinates: 2391840..2392577 (+)
• Length: 246 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: A0A151UPU1
• Locus tag: BA202_RS12595
• Protein ID: WP_000588714.1
• Coordinates: 2392685..2392813 (+)
• Length: 43 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BA202_RS12560	2387364..2388146	+	783	WP_000381776.1	class I SAM-dependent methyltransferase	-
BA202_RS12565	2388324..2390009	-	1686	WP_033677799.1	alpha-keto acid decarboxylase family protein	-
BA202_RS12570	2390117..2390599	+	483	WP_016717517.1	MarR family winged helix-turn-helix transcriptional regulator	-
BA202_RS12575	2390766..2391503	+	738	WP_000594137.1	2,3-diphosphoglycerate-dependent phosphoglycerate mutase	-
BA202_RS12590	2391840..2392577	+	738	WP_014893739.1	type II toxin-antitoxin system SpoIISA family toxin	Toxin
BA202_RS12595	2392685..2392813	+	129	WP_000588714.1	hypothetical protein	Antitoxin
BA202_RS29440	2392886..2393062	+	177	WP_000852590.1	hypothetical protein	-
BA202_RS12605	2393081..2393470	-	390	WP_016717519.1	YxeA family protein	-
BA202_RS12610	2393687..2395156	+	1470	WP_016717520.1	beta-Ala-His dipeptidase	-
BA202_RS12615	2395357..2395962	+	606	Protein_2310	CatB-related O-acetyltransferase	-
BA202_RS12620	2396076..2397232	+	1157	WP_088883303.1	IS3 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SpoIISA, type II toxin-antitoxin system (9-243)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 246 a.a.
• Molecular weight: 28351.07 Da
• Isoelectric Point: 8.2998

>T64398 WP_014893739.1 NZ_CP016316:2391840-2392577 [Bacillus cereus]
VISNIRIGLFILAIVFLVLVFFYWKNEELYEEKKQRIRKTWYGLFIISVTVYFMVKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNVFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSIIVPFEHIEQLNEQKAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Nucleotide

• Length: 738 bp

>T64398 NZ_CP016316:2391840-2392577 [Bacillus cereus]
GTGATCTCTAACATTCGAATCGGCTTATTTATTTTAGCAATCGTTTTTCTAGTACTTGTTTTCTTTTATTGGAAAAACGA
AGAGTTGTACGAGGAGAAGAAGCAACGAATTAGAAAGACTTGGTATGGGTTGTTTATAATATCAGTCACCGTGTATTTCA
TGGTAAAAGGAATTGATTTAACCCTCTGGAAAAATCTTTTAATGTTCACTGCAATGGTTATTTTCGTTGATATTGCATTT
ATTTTAACACCTAATATTTCAGAAATATGGGGAGCAAAATTTAGCGATATCGGCAAGACTGTTCAATCGATAAAACGGTC
ATTAATTGCTTCTAAAGCAAGAGGAGAAATATACACAACAATTATTCAAAATGTCAATCCGGCAGTATTCGGTACGATGG
AATGGCATACGGAAGAAGAATATACAAAAAGCTTAAACGTATTTTTAGATTCGTATGGTGAAAAGATTGGGGCAAAAATT
GTTGTATTTGAAGCGGCAAAGGAATTAAATACCAACTTTCGCGGTATCCGTTCTCAATTTAGTATCATCGTTCCGTTTGA
ACATATTGAGCAATTGAATGAGCAGAAAGCGGTGCAAGTAGAAAATGTCGGAATTATACCAGCAAAAATAGTGAGTGATG
TTTTCATTGTTATTGATGGTAAGAAAAATAACCTGCAAGATCGAGATTTTGAAAATGTATATAATTTAACAATACATCAT
AGTTATTTTAGTAAGTAG

Antitoxin

Protein

• Length: 43 a.a.
• Molecular weight: 5024.48 Da
• Isoelectric Point: 4.0932

>AT64398 WP_000588714.1 NZ_CP016316:2392685-2392813 [Bacillus cereus]
VIKDYDNDFFKKDNEDTTDFSLIKGDTLQQVEELEEELKRKS

Nucleotide

• Length: 129 bp

>AT64398 NZ_CP016316:2392685-2392813 [Bacillus cereus]
GTGATAAAAGATTATGACAATGATTTTTTTAAAAAAGATAATGAAGATACAACAGATTTCTCGTTAATAAAAGGAGATAC
ATTACAGCAAGTAGAAGAGCTAGAAGAAGAATTAAAAAGAAAATCATAA

Structures

Antitoxin

• AlphaFold DB: A0A151UPU1