64394

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-yefM/YoeB-RelB
Location 92506..93022 Replicon plasmid pVS127
Accession NZ_CP016309
Organism Vibrio scophthalmi strain VS-12

Toxin (Protein)


Gene name relB Uniprot ID A0A1B1NWU9
Locus tag VSVS12_RS21940 Protein ID WP_065432190.1
Coordinates 92753..93022 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A1B1NWU5
Locus tag VSVS12_RS21935 Protein ID WP_065432189.1
Coordinates 92506..92760 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VSVS12_RS21910 88246..88506 + 261 WP_065432184.1 hypothetical protein -
VSVS12_RS21915 88523..89530 + 1008 WP_065432185.1 nucleoid-associated protein YejK -
VSVS12_RS21920 90475..90744 + 270 WP_065432186.1 hypothetical protein -
VSVS12_RS21925 90877..91461 + 585 WP_065432187.1 DUF2913 family protein -
VSVS12_RS21930 91473..91715 - 243 WP_065432188.1 DinI-like family protein -
VSVS12_RS23330 91948..92121 + 174 WP_197498457.1 hypothetical protein -
VSVS12_RS21935 92506..92760 + 255 WP_065432189.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
VSVS12_RS21940 92753..93022 + 270 WP_065432190.1 Txe/YoeB family addiction module toxin Toxin
VSVS12_RS21945 93034..93597 - 564 WP_065432191.1 recombinase family protein -
VSVS12_RS21950 94048..95256 - 1209 WP_065432192.1 IS256 family transposase -
VSVS12_RS21955 95528..97303 - 1776 WP_065432193.1 ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..127447 127447
- flank IS/Tn - - 94048..95256 1208


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(10-89)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10600.03 Da        Isoelectric Point: 9.4082

>T64394 WP_065432190.1 NZ_CP016309:92753-93022 [Vibrio scophthalmi]
MSSSQRLLSWTNEAWEDYLYWQTQDKKTLKRINKLIIDAKRSPFEGIGKPEALKENLTGFWSRRIDDTNRLVYAVDNQAI
TIISCRYHY

Download         Length: 270 bp

>T64394 NZ_CP016309:92753-93022 [Vibrio scophthalmi]
ATGAGTAGTAGTCAGCGTTTGTTGTCCTGGACAAATGAAGCTTGGGAAGATTACCTCTATTGGCAGACACAAGATAAGAA
GACTCTCAAGCGTATAAATAAACTCATTATTGATGCAAAGCGTTCTCCATTCGAAGGTATTGGTAAACCCGAGGCATTAA
AAGAGAACCTAACGGGTTTTTGGTCTCGGCGGATAGATGATACAAACCGTTTAGTCTATGCTGTTGATAATCAAGCTATA
ACGATTATTTCTTGTCGTTATCATTACTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9569.70 Da        Isoelectric Point: 4.7914

>AT64394 WP_065432189.1 NZ_CP016309:92506-92760 [Vibrio scophthalmi]
MRIVSFTEARNSLKAVLDRVVNDADTAVITRRDSEDAVVMSLDYYNSLMETVHLLRSPENAEHLNRSIAQYRAGNSTPRE
LMDE

Download         Length: 255 bp

>AT64394 NZ_CP016309:92506-92760 [Vibrio scophthalmi]
ATGAGAATAGTTTCTTTTACCGAAGCTAGGAATAGTTTAAAAGCAGTGTTAGATCGGGTAGTTAATGATGCTGACACTGC
GGTTATTACGCGCAGAGATTCAGAAGACGCAGTAGTAATGTCGTTAGACTACTACAATAGTTTGATGGAAACGGTTCATC
TTCTCCGTTCACCAGAAAACGCTGAGCATTTGAACCGTTCTATTGCGCAGTATCGTGCTGGTAACTCAACACCACGAGAG
CTCATGGATGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B1NWU9

Antitoxin

Source ID Structure
AlphaFold DB A0A1B1NWU5

References