Detailed information of TA system TA064392

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafN(antitoxin)
• Location: 1136912..1137477
• Replicon: chromosome
• Accession: NZ_CP016308
• Organism: Vibrio scophthalmi strain VS-12

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A1B1NW25
• Locus tag: VSVS12_RS19870
• Protein ID: WP_065431834.1
• Coordinates: 1136912..1137199 (-)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A1B1NVK0
• Locus tag: VSVS12_RS19875
• Protein ID: WP_065431835.1
• Coordinates: 1137199..1137477 (-)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
VSVS12_RS19840	1132726..1133220	-	495	WP_083181539.1	hypothetical protein	-
VSVS12_RS22815	1133826..1133918	-	93	WP_075111373.1	DUF3265 domain-containing protein	-
VSVS12_RS19845	1134075..1134293	+	219	WP_038896800.1	hypothetical protein	-
VSVS12_RS23300	1134989..1135153	-	165	WP_197498421.1	hypothetical protein	-
VSVS12_RS19855	1135216..1135491	-	276	WP_197498452.1	VanZ family protein	-
VSVS12_RS19860	1135720..1136220	-	501	WP_083181543.1	GNAT family N-acetyltransferase	-
VSVS12_RS19865	1136469..1136747	+	279	WP_065431833.1	hypothetical protein	-
VSVS12_RS19870	1136912..1137199	-	288	WP_065431834.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
VSVS12_RS19875	1137199..1137477	-	279	WP_065431835.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
VSVS12_RS23105	1137817..1137987	+	171	WP_156773193.1	hypothetical protein	-
VSVS12_RS19880	1138256..1138675	-	420	WP_065431836.1	DUF2513 domain-containing protein	-
VSVS12_RS19885	1139381..1139770	-	390	WP_156773194.1	hypothetical protein	-
VSVS12_RS23305	1140021..1140188	+	168	WP_197498422.1	hypothetical protein	-
VSVS12_RS22830	1140348..1140440	-	93	WP_197498423.1	DUF3265 domain-containing protein	-
VSVS12_RS19890	1140465..1140656	-	192	WP_065431838.1	hypothetical protein	-
VSVS12_RS19895	1140833..1141249	-	417	WP_065431839.1	hypothetical protein	-
VSVS12_RS19900	1141425..1141772	-	348	WP_060467711.1	DUF3024 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integron	-	-	1121237..1166922	45685

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-89)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-74)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 10906.67 Da
• Isoelectric Point: 5.0892

>T64392 WP_065431834.1 NZ_CP016308:c1137199-1136912 [Vibrio scophthalmi]
MKVVWSPLALEKLGDAAEFIALDNPAAAKNWVNEIFDKTDLLGTMPEMGRMVPEMPHTQYREILFGHYRIIYSLGLEIRI
LTVRNCRQQLSESDV

Nucleotide

• Length: 288 bp

>T64392 NZ_CP016308:c1137199-1136912 [Vibrio scophthalmi]
ATGAAAGTAGTTTGGTCTCCATTAGCTCTCGAAAAGCTTGGTGATGCTGCTGAGTTCATTGCATTAGATAACCCAGCGGC
TGCAAAAAACTGGGTTAATGAGATTTTCGATAAAACTGATTTACTTGGGACTATGCCTGAAATGGGACGAATGGTTCCAG
AAATGCCACATACGCAATATCGTGAAATCTTGTTTGGTCACTATCGTATTATTTACAGTTTAGGTCTTGAAATTCGCATT
TTGACTGTTCGTAACTGTCGTCAGCAGTTATCTGAAAGTGACGTCTAA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10298.79 Da
• Isoelectric Point: 5.1548

>AT64392 WP_065431835.1 NZ_CP016308:c1137477-1137199 [Vibrio scophthalmi]
MSRIHFDQDIQPLSEFRAGVTSFIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLASGLGVSN
EDARAQVLGRIK

Nucleotide

• Length: 279 bp

>AT64392 NZ_CP016308:c1137477-1137199 [Vibrio scophthalmi]
ATGAGTCGCATTCATTTCGATCAAGATATTCAGCCTCTATCTGAGTTTCGTGCAGGTGTAACCTCATTCATTAAACAAAT
TAATGAGACACGCCGACCTTTAGTGATTACTCAGCGCGGTAAGGGTGTTGCAGTTGTACTCGACGTTGCAGAGTATGAAG
CAATGCAGGAAAAAATTGAGTTACTGGAAGAGATGAGAACAGCAGAAGCACAATTAGCTTCGGGGTTAGGTGTATCTAAT
GAAGATGCTCGTGCTCAAGTGCTGGGGCGTATCAAATAA

Structures

Toxin

• AlphaFold DB: A0A1B1NW25

Antitoxin

• AlphaFold DB: A0A1B1NVK0