64391

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 852458..852986 Replicon chromosome
Accession NZ_CP016308
Organism Vibrio scophthalmi strain VS-12

Toxin (Protein)


Gene name relE Uniprot ID A0A1B1NUS2
Locus tag VSVS12_RS18600 Protein ID WP_065431665.1
Coordinates 852699..852986 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A1B1NVB9
Locus tag VSVS12_RS18595 Protein ID WP_065431664.1
Coordinates 852458..852709 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VSVS12_RS18575 848790..849725 - 936 WP_065431661.1 biotin-dependent carboxyltransferase family protein -
VSVS12_RS18580 849718..850428 - 711 WP_065431662.1 allophanate hydrolase subunit 1 -
VSVS12_RS18585 850418..851170 - 753 WP_065431663.1 LamB/YcsF family protein -
VSVS12_RS18590 851430..852251 + 822 Protein_737 UDP-glucose 4-epimerase GalE -
VSVS12_RS18595 852458..852709 + 252 WP_065431664.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
VSVS12_RS18600 852699..852986 + 288 WP_065431665.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
VSVS12_RS18605 853025..853993 - 969 WP_083181510.1 IS30 family transposase -
VSVS12_RS18610 854087..854281 + 195 Protein_741 GDP-mannose 4,6-dehydratase -
VSVS12_RS18615 854433..856424 - 1992 WP_065431667.1 transketolase -
VSVS12_RS18620 856519..857469 - 951 WP_065431668.1 transaldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 853025..853957 932


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(11-71)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11078.09 Da        Isoelectric Point: 10.5506

>T64391 WP_065431665.1 NZ_CP016308:852699-852986 [Vibrio scophthalmi]
MTYKLKFLPAAKKEWSKLAPPIQSQFKKKLKERLENPHVPSSKLRGYESVYKIKLRTAGYRLAYEVIDDEIVVYVLAIGK
RDKDAVYKKLASRFS

Download         Length: 288 bp

>T64391 NZ_CP016308:852699-852986 [Vibrio scophthalmi]
ATGACTTATAAACTTAAATTTCTGCCCGCTGCAAAGAAAGAGTGGAGCAAATTAGCTCCACCAATTCAAAGTCAGTTTAA
AAAGAAACTTAAGGAACGCCTCGAAAATCCACATGTTCCATCTTCCAAGCTCCGTGGTTACGAATCGGTTTACAAGATCA
AATTGCGGACAGCAGGCTACCGTCTAGCTTATGAAGTTATTGATGATGAAATTGTCGTATACGTGTTAGCCATAGGAAAA
CGTGACAAAGATGCAGTGTATAAAAAACTAGCTTCAAGGTTCTCGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9183.40 Da        Isoelectric Point: 3.9727

>AT64391 WP_065431664.1 NZ_CP016308:852458-852709 [Vibrio scophthalmi]
MRQVLADCSASISELKKNPTALLNEADGSAIAILNHNKPAAYLVPAETYEFLMDMLDDYELAKLVESRRVDLSEAVEVDI
DDL

Download         Length: 252 bp

>AT64391 NZ_CP016308:852458-852709 [Vibrio scophthalmi]
ATGAGACAAGTTTTAGCAGATTGCTCAGCAAGTATTTCTGAGCTAAAGAAAAACCCAACCGCTTTACTAAATGAAGCTGA
TGGTTCTGCTATTGCTATTTTAAACCACAACAAGCCCGCAGCTTATCTTGTTCCTGCGGAAACTTACGAGTTTCTGATGG
ATATGCTTGATGACTATGAGCTTGCAAAGCTTGTTGAAAGTCGTCGTGTTGACTTATCTGAAGCTGTGGAAGTTGATATC
GATGACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B1NUS2

Antitoxin

Source ID Structure
AlphaFold DB A0A1B1NVB9

References