64390

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) sanaTA/AbiEii-DUF6088
Location 1081873..1083220 Replicon chromosome
Accession NZ_CP016307
Organism Vibrio scophthalmi strain VS-12

Toxin (Protein)


Gene name sanaT Uniprot ID A0A1B1NMC4
Locus tag VSVS12_RS05120 Protein ID WP_065429987.1
Coordinates 1081873..1082814 (-) Length 314 a.a.

Antitoxin (Protein)


Gene name sanaA Uniprot ID A0A1B1NML2
Locus tag VSVS12_RS05125 Protein ID WP_021018080.1
Coordinates 1082816..1083220 (-) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VSVS12_RS05105 1078203..1079039 - 837 WP_065429984.1 hypothetical protein -
VSVS12_RS05110 1079105..1080346 - 1242 WP_065429985.1 restriction endonuclease subunit S -
VSVS12_RS05115 1080336..1081853 - 1518 WP_065429986.1 type I restriction-modification system subunit M -
VSVS12_RS05120 1081873..1082814 - 942 WP_065429987.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
VSVS12_RS05125 1082816..1083220 - 405 WP_021018080.1 hypothetical protein Antitoxin
VSVS12_RS05130 1083409..1084002 - 594 WP_065429988.1 tyrosine-type recombinase/integrase -
VSVS12_RS05135 1084309..1085826 + 1518 WP_083181314.1 ISNCY family transposase -
VSVS12_RS05140 1085953..1086609 - 657 WP_065429989.1 recombinase family protein -
VSVS12_RS05145 1086649..1087113 - 465 WP_065429990.1 thioredoxin-dependent thiol peroxidase -
VSVS12_RS05150 1087274..1087777 - 504 WP_065429991.1 bacterioferritin comigratory protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1080336..1093717 13381
- flank IS/Tn - - 1084318..1085826 1508


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(37-300)

Antitoxin

Protein of unknown function DUF6088

(7-130)


Sequences

Toxin        


Download         Length: 314 a.a.        Molecular weight: 35795.23 Da        Isoelectric Point: 5.2980

>T64390 WP_065429987.1 NZ_CP016307:c1082814-1081873 [Vibrio scophthalmi]
MNTLKQQFLEVSDALELGNPAIIEKDYWVVALLAELAKVCPEHHQMVFSGGTALAKSNVKILRMSEDVDIKLIPNPAFDE
LSRAKKKAARKACVNEIEQAITQSERFTVEERSVRDEYRYVEFELKYPQQFSQAPCLRPIIKLELIETIPLLDVQPRSIQ
SLLAELYQQPHEVSAFDCASIHATLVEKIISMLRRTMSVKRNTERSDDVALVRHIYDVHCITTLSMPELDSIDGLFKAVL
AEDIARFGNQHAEFVANPKQELQLGLKELEENAIFRQRFQEFVTPMVFNTEPHDFDTCFASFKRIAASLIEKI

Download         Length: 942 bp

>T64390 NZ_CP016307:c1082814-1081873 [Vibrio scophthalmi]
ATGAACACACTAAAACAACAATTCCTTGAGGTTTCCGATGCGCTTGAGCTCGGAAACCCAGCCATTATTGAAAAAGATTA
CTGGGTCGTGGCTTTACTGGCTGAGCTAGCGAAAGTTTGTCCTGAGCATCATCAAATGGTGTTTTCTGGCGGCACTGCGT
TGGCAAAATCAAACGTTAAAATTCTAAGAATGTCGGAAGATGTGGATATAAAACTCATCCCCAACCCAGCATTTGATGAA
CTGAGTCGAGCGAAAAAGAAAGCCGCGAGAAAGGCATGTGTTAACGAGATTGAACAGGCGATCACTCAGTCAGAGCGATT
TACCGTTGAAGAGCGTTCTGTGCGAGATGAGTACCGCTACGTTGAGTTTGAACTTAAATACCCGCAGCAATTTAGTCAAG
CGCCCTGCCTGCGCCCCATCATCAAGTTAGAGTTAATCGAAACCATTCCATTACTGGATGTGCAGCCGCGCAGCATTCAA
TCTCTGCTCGCAGAGTTATACCAACAACCGCACGAAGTGAGTGCATTTGATTGCGCCTCTATCCATGCCACATTGGTTGA
AAAAATTATTTCAATGCTGCGCCGTACCATGTCGGTAAAACGCAATACGGAGCGAAGCGATGATGTTGCTTTAGTTCGCC
ATATCTACGATGTGCACTGCATAACAACGCTCTCAATGCCAGAACTCGACTCGATTGACGGTCTATTCAAAGCGGTATTG
GCAGAAGATATTGCCCGCTTTGGCAATCAACATGCCGAGTTTGTTGCCAACCCCAAACAAGAGCTACAACTTGGCCTCAA
AGAGCTTGAGGAAAATGCAATATTCCGCCAACGCTTTCAGGAATTTGTCACGCCAATGGTGTTTAACACCGAACCCCATG
ATTTTGATACCTGCTTTGCCTCATTTAAACGCATTGCAGCATCGCTAATTGAAAAAATTTAA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 15200.53 Da        Isoelectric Point: 10.5319

>AT64390 WP_021018080.1 NZ_CP016307:c1083220-1082816 [Vibrio scophthalmi]
MTAADRIYQKIKRSRRYVFERKDFDGFASYDQIGRALRQLVQQGELMKLGYGLYTKARINSLTGKPMPTNPGGTDALMRE
ILKMKGVDFEMDSLSLQSLSGTSTQIPSSIQYSWDPKQFNRKLVVGSRVLNLPS

Download         Length: 405 bp

>AT64390 NZ_CP016307:c1083220-1082816 [Vibrio scophthalmi]
ATGACAGCAGCAGACCGCATTTATCAAAAGATAAAGCGTTCAAGACGTTATGTATTTGAACGCAAAGATTTTGATGGATT
TGCAAGCTACGACCAAATAGGTCGGGCACTCAGACAGCTTGTTCAACAAGGTGAGTTAATGAAGCTTGGATATGGTTTGT
ATACCAAAGCAAGAATCAATAGCCTCACTGGTAAGCCCATGCCCACTAATCCAGGTGGCACCGATGCTCTTATGCGAGAA
ATTCTTAAAATGAAAGGCGTTGATTTTGAGATGGATAGTCTATCGCTGCAAAGTCTTTCAGGCACGAGTACCCAAATTCC
ATCTTCTATTCAGTATTCATGGGACCCAAAACAGTTTAATCGCAAACTGGTGGTCGGTAGCCGTGTGCTGAACTTACCAA
GTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B1NMC4

Antitoxin

Source ID Structure
AlphaFold DB A0A1B1NML2

References