Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapC-vagC/VapC-VagC
Location 514693..515327 Replicon chromosome
Accession NZ_CP016303
Organism Candidatus Hamiltonella defensa (Bemisia tabaci) strain MEAM1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag BA171_RS02485 Protein ID WP_095591350.1
Coordinates 514693..515091 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag BA171_RS02490 Protein ID WP_016858197.1
Coordinates 515091..515327 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BA171_RS02445 509848..510330 + 483 WP_050879637.1 hypothetical protein -
BA171_RS02450 510466..511107 + 642 WP_198303390.1 ash family protein -
BA171_RS08645 511109..511261 + 153 WP_016858005.1 hypothetical protein -
BA171_RS02455 511254..512159 + 906 WP_046493793.1 replication protein -
BA171_RS02460 512156..513007 + 852 WP_095591349.1 ATP-binding protein -
BA171_RS02465 513004..513213 + 210 WP_046493771.1 hypothetical protein -
BA171_RS02470 513210..513590 + 381 WP_046493753.1 RusA family crossover junction endodeoxyribonuclease -
BA171_RS02475 513587..513925 + 339 WP_046493754.1 hypothetical protein -
BA171_RS02480 514067..514312 + 246 WP_016858311.1 hypothetical protein -
BA171_RS02485 514693..515091 - 399 WP_095591350.1 type II toxin-antitoxin system VapC family toxin Toxin
BA171_RS02490 515091..515327 - 237 WP_016858197.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
BA171_RS02495 515444..515626 - 183 WP_046493773.1 hypothetical protein -
BA171_RS02500 515650..516732 + 1083 Protein_484 site-specific DNA-methyltransferase -
BA171_RS02505 516803..516991 + 189 WP_015873507.1 phage holin family protein -
BA171_RS02510 516988..517485 + 498 WP_046493798.1 lysozyme -
BA171_RS02515 517588..517860 + 273 WP_052735024.1 glycoside hydrolase family protein -
BA171_RS02520 517946..518425 + 480 WP_052735025.1 lysis protein -
BA171_RS02525 518487..518846 + 360 WP_029589155.1 HNH endonuclease -
BA171_RS02530 519024..519492 + 469 Protein_490 phage terminase small subunit P27 family -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 474278..542171 67893


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-117)

Antitoxin

SpoVT-AbrB domain

(7-44)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15099.67 Da        Isoelectric Point: 9.4190

>T64387 WP_095591350.1 NZ_CP016303:c515091-514693 [Candidatus Hamiltonella defensa (Bemisia tabaci)]
MPRYMLDTNMCIYLIKNQPKQVARRFVNCFVGDVVMSAITFAELDYGVAVSKDPERELNNLNKLVKLINVMPFDANAARA
YGAVRMAKRERKKDHLDKLIASHAIALNIILVTNNERDFIAYPGLQIENWIT

Download         Length: 399 bp

>T64387 NZ_CP016303:c515091-514693 [Candidatus Hamiltonella defensa (Bemisia tabaci)]
ATGCCTCGCTACATGCTGGATACAAACATGTGTATTTACCTCATCAAAAACCAGCCAAAACAGGTAGCAAGACGCTTCGT
GAACTGCTTCGTTGGCGATGTTGTTATGTCAGCAATTACCTTTGCCGAATTAGACTACGGAGTAGCGGTATCCAAGGATC
CAGAACGCGAGCTAAATAACCTTAATAAACTCGTGAAACTGATAAATGTAATGCCATTTGATGCCAATGCTGCTCGCGCC
TATGGTGCAGTTCGAATGGCCAAAAGAGAGCGGAAGAAAGACCATCTAGACAAGCTAATAGCTTCACATGCCATTGCATT
AAACATCATACTAGTGACTAACAACGAACGCGATTTCATCGCTTATCCAGGTCTTCAAATCGAAAACTGGATAACATAG

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8849.85 Da        Isoelectric Point: 4.1964

>AT64387 WP_016858197.1 NZ_CP016303:c515327-515091 [Candidatus Hamiltonella defensa (Bemisia tabaci)]
MQTTKIFKNGNSQAVRIPAGLAFDNTDMELEIERIGDEIRIRPARQSLENVMDIFASFSPDFMSEGRADQEQADRDTL

Download         Length: 237 bp

>AT64387 NZ_CP016303:c515327-515091 [Candidatus Hamiltonella defensa (Bemisia tabaci)]
ATGCAAACAACAAAGATATTCAAAAATGGCAATTCACAAGCAGTAAGAATCCCTGCTGGACTTGCTTTTGACAATACAGA
TATGGAGCTTGAAATCGAACGCATTGGCGATGAAATCCGGATTCGGCCCGCTCGTCAGTCCCTGGAAAATGTGATGGATA
TATTTGCCAGCTTTTCACCTGATTTTATGTCTGAAGGTCGTGCTGATCAGGAACAGGCAGATAGGGATACCCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References