Detailed information of TA system TA064384

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1562792..1563471
• Replicon: chromosome
• Accession: NZ_CP016300
• Organism: Acinetobacter baumannii strain CMC-CR-MDR-Ab66

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: AOT18_RS07420
• Protein ID: WP_000838146.1
• Coordinates: 1562792..1562974 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9L2H6
• Locus tag: AOT18_RS07425
• Protein ID: WP_000966688.1
• Coordinates: 1563067..1563471 (+)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AOT18_RS07375	1557865..1558269	+	405	WP_000247948.1	hypothetical protein	-
AOT18_RS07380	1558241..1558609	+	369	WP_002055488.1	hypothetical protein	-
AOT18_RS07385	1558611..1559009	+	399	WP_001251850.1	hypothetical protein	-
AOT18_RS07390	1559011..1559229	+	219	WP_001277687.1	hypothetical protein	-
AOT18_RS07395	1559323..1559676	+	354	WP_000064599.1	hypothetical protein	-
AOT18_RS07400	1559676..1560911	+	1236	WP_000002422.1	hypothetical protein	-
AOT18_RS07405	1560964..1561881	+	918	WP_000094250.1	hypothetical protein	-
AOT18_RS07410	1561951..1562466	+	516	WP_001185608.1	hypothetical protein	-
AOT18_RS07420	1562792..1562974	+	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
AOT18_RS07425	1563067..1563471	+	405	WP_000966688.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
AOT18_RS07430	1563570..1563746	+	177	WP_014466185.1	hypothetical protein	-
AOT18_RS07435	1563755..1564078	+	324	WP_000523922.1	DUF4236 domain-containing protein	-
AOT18_RS07440	1564110..1564904	+	795	WP_000720608.1	hypothetical protein	-
AOT18_RS07445	1564953..1565192	-	240	WP_000763623.1	Arc family DNA-binding protein	-
AOT18_RS07450	1565315..1565470	+	156	WP_001103649.1	Arc family DNA-binding protein	-
AOT18_RS07455	1565467..1566459	+	993	WP_000835645.1	KilA-N domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1531518..1589808	58290

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T64384 WP_000838146.1 NZ_CP016300:1562792-1562974 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T64384 NZ_CP016300:1562792-1562974 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGATGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
TAAACACCCAACCAAAAAGGGGTTAGTTACAATCCCACATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAACAAGCGGGTCTAAATTGA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14647.69 Da
• Isoelectric Point: 4.4328

>AT64384 WP_000966688.1 NZ_CP016300:1563067-1563471 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT64384 NZ_CP016300:1563067-1563471 [Acinetobacter baumannii]
ATGTTATATCCAATTGCAATTGAACGAGGATCAGATACTGAGGCATTTGGTGTCACTGTTCCTGATATTCCAGGTTGTTT
TAGTGCTGGTGACACACTTGAAGAAGCTATTGAGAATGTTAAAGAAGCTATTTCAGGCCATTTAGAAATATTGGCTGAAG
ATGGTGAGGAAATCCCATTAGCTTCCGAACTAGTTAAATTTGTCGATGATCCTGAATATAAAGGAATGATCTGGGCGGTT
ACCGAAGTTGATGTTAGTCGTTATCTGGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: N9L2H6