Detailed information of TA system TA064382

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1563695..1564374
• Replicon: chromosome
• Accession: NZ_CP016298
• Organism: Acinetobacter baumannii strain CMC-MDR-Ab59

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: AOT17_RS07425
• Protein ID: WP_000838146.1
• Coordinates: 1563695..1563877 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9L2H6
• Locus tag: AOT17_RS07430
• Protein ID: WP_000966688.1
• Coordinates: 1563970..1564374 (+)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AOT17_RS07380	1558768..1559172	+	405	WP_000247948.1	hypothetical protein	-
AOT17_RS07385	1559144..1559512	+	369	WP_002055488.1	hypothetical protein	-
AOT17_RS07390	1559514..1559912	+	399	WP_001251850.1	hypothetical protein	-
AOT17_RS07395	1559914..1560132	+	219	WP_001277687.1	hypothetical protein	-
AOT17_RS07400	1560226..1560579	+	354	WP_000064599.1	hypothetical protein	-
AOT17_RS07405	1560579..1561814	+	1236	WP_000002422.1	hypothetical protein	-
AOT17_RS07410	1561867..1562784	+	918	WP_000094250.1	hypothetical protein	-
AOT17_RS07415	1562854..1563369	+	516	WP_001185608.1	hypothetical protein	-
AOT17_RS07425	1563695..1563877	+	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
AOT17_RS07430	1563970..1564374	+	405	WP_000966688.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
AOT17_RS07435	1564473..1564649	+	177	WP_014466185.1	hypothetical protein	-
AOT17_RS07440	1564658..1564981	+	324	WP_000523922.1	DUF4236 domain-containing protein	-
AOT17_RS07445	1565013..1565807	+	795	WP_000720608.1	hypothetical protein	-
AOT17_RS07450	1565856..1566095	-	240	WP_000763623.1	Arc family DNA-binding protein	-
AOT17_RS07455	1566218..1566373	+	156	WP_001103649.1	Arc family DNA-binding protein	-
AOT17_RS07460	1566370..1567362	+	993	WP_000835645.1	KilA-N domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1532421..1591559	59138

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T64382 WP_000838146.1 NZ_CP016298:1563695-1563877 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T64382 NZ_CP016298:1563695-1563877 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGATGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
TAAACACCCAACCAAAAAGGGGTTAGTTACAATCCCACATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAACAAGCGGGTCTAAATTGA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14647.69 Da
• Isoelectric Point: 4.4328

>AT64382 WP_000966688.1 NZ_CP016298:1563970-1564374 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT64382 NZ_CP016298:1563970-1564374 [Acinetobacter baumannii]
ATGTTATATCCAATTGCAATTGAACGAGGATCAGATACTGAGGCATTTGGTGTCACTGTTCCTGATATTCCAGGTTGTTT
TAGTGCTGGTGACACACTTGAAGAAGCTATTGAGAATGTTAAAGAAGCTATTTCAGGCCATTTAGAAATATTGGCTGAAG
ATGGTGAGGAAATCCCATTAGCTTCCGAACTAGTTAAATTTGTCGATGATCCTGAATATAAAGGAATGATCTGGGCGGTT
ACCGAAGTTGATGTTAGTCGTTATCTGGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: N9L2H6