Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 3791712..3792244 Replicon chromosome
Accession NZ_CP016286
Organism Rhizobium leguminosarum strain Vaf10

Toxin (Protein)


Gene name parE Uniprot ID A0A1B1CCR9
Locus tag BA011_RS18575 Protein ID WP_065281534.1
Coordinates 3791712..3792002 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A179C0U9
Locus tag BA011_RS18580 Protein ID WP_020052017.1
Coordinates 3791999..3792244 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BA011_RS18565 3788555..3789889 - 1335 WP_065279157.1 ISNCY family transposase -
BA011_RS18570 3790383..3791606 - 1224 WP_065282593.1 argininosuccinate synthase -
BA011_RS18575 3791712..3792002 - 291 WP_065281534.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BA011_RS18580 3791999..3792244 - 246 WP_020052017.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
BA011_RS18585 3792332..3793183 + 852 WP_065281535.1 SDR family NAD(P)-dependent oxidoreductase -
BA011_RS18590 3793375..3794016 + 642 WP_065281536.1 LysE family translocator -
BA011_RS44365 3794398..3794652 - 255 WP_065281537.1 hypothetical protein -
BA011_RS18600 3794728..3795522 - 795 WP_018072069.1 ABC transporter ATP-binding protein -
BA011_RS18605 3795519..3796397 - 879 WP_017989717.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-91)

Antitoxin

Antitoxin ParD

(2-77)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 10892.61 Da        Isoelectric Point: 8.8450

>T64367 WP_065281534.1 NZ_CP016286:c3792002-3791712 [Rhizobium leguminosarum]
MKALVLSPAAVDDIDRIYDYTEEKWGQGQAEDYIVALRGYCEALAAQTKHGRKIIGLRSGYTALAFRSHFVIYAETEKVL
TVIRILHRRMNIAAHL

Download         Length: 291 bp

>T64367 NZ_CP016286:c3792002-3791712 [Rhizobium leguminosarum]
ATGAAAGCGCTTGTTCTCTCGCCAGCCGCTGTCGATGATATCGACAGGATTTATGACTATACCGAAGAGAAATGGGGCCA
AGGTCAAGCGGAGGACTATATCGTTGCGCTCCGGGGTTACTGCGAGGCGCTTGCAGCACAGACAAAGCATGGCCGCAAAA
TCATTGGATTGAGGAGCGGCTACACCGCCCTGGCGTTTCGCTCGCATTTCGTCATTTACGCTGAGACCGAAAAAGTGTTG
ACGGTTATTCGCATCCTGCATCGGCGCATGAATATCGCGGCTCATCTCTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8956.07 Da        Isoelectric Point: 4.6677

>AT64367 WP_020052017.1 NZ_CP016286:c3792244-3791999 [Rhizobium leguminosarum]
VAKVVSIRIDDHMEEFIGNQLDQGAYGSADEVIDAGLRLLQREAELAAIEAAIIEGEKSGKPRPFDFDAFIEGKRARRGR
Q

Download         Length: 246 bp

>AT64367 NZ_CP016286:c3792244-3791999 [Rhizobium leguminosarum]
GTGGCCAAGGTCGTGTCCATCAGAATCGATGACCACATGGAGGAATTTATCGGCAATCAACTCGATCAGGGAGCCTATGG
CTCCGCAGACGAGGTGATCGACGCCGGCTTGAGGCTTCTGCAGCGCGAGGCAGAGCTTGCGGCAATCGAGGCAGCCATTA
TCGAAGGTGAGAAATCTGGCAAACCACGGCCTTTTGATTTTGATGCTTTTATCGAGGGAAAGCGAGCGCGACGCGGCCGC
CAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B1CCR9

Antitoxin

Source ID Structure
AlphaFold DB A0A179C0U9

References