Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2427851..2428524 Replicon chromosome
Accession NZ_CP016286
Organism Rhizobium leguminosarum strain Vaf10

Toxin (Protein)


Gene name vapC Uniprot ID A0A1B1C9P8
Locus tag BA011_RS12180 Protein ID WP_065280657.1
Coordinates 2427851..2428264 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A1B1C9H1
Locus tag BA011_RS12185 Protein ID WP_065280658.1
Coordinates 2428261..2428524 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BA011_RS12170 2425297..2426504 - 1208 Protein_2440 efflux RND transporter periplasmic adaptor subunit -
BA011_RS12175 2426757..2427671 - 915 WP_065280656.1 adenylate/guanylate cyclase domain-containing protein -
BA011_RS12180 2427851..2428264 - 414 WP_065280657.1 type II toxin-antitoxin system VapC family toxin Toxin
BA011_RS12185 2428261..2428524 - 264 WP_065280658.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
BA011_RS12190 2428648..2430198 - 1551 WP_065280659.1 SpoVR family protein -
BA011_RS12195 2430195..2431469 - 1275 WP_065280660.1 YeaH/YhbH family protein -
BA011_RS12200 2431482..2433425 - 1944 WP_027664285.1 PrkA family serine protein kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-124)

Antitoxin

SpoVT-AbrB domain

(9-54)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 15180.53 Da        Isoelectric Point: 5.2217

>T64365 WP_065280657.1 NZ_CP016286:c2428264-2427851 [Rhizobium leguminosarum]
MTAWMLDTNMVSHVIKGDRPEIIERLAALPIEEIVISSITEGELFYGLAKRGYPKALSERIRQFLLRVDVLPWDHDVTRT
YGDLRAACDAKGVTLAPLDMMIAAHAVATAATLVTRDKAFARVSEPLKVDDWANEGS

Download         Length: 414 bp

>T64365 NZ_CP016286:c2428264-2427851 [Rhizobium leguminosarum]
ATGACGGCCTGGATGCTCGATACCAACATGGTGAGCCATGTCATCAAGGGCGATCGGCCGGAGATCATCGAAAGGTTGGC
CGCGCTTCCGATCGAGGAGATCGTCATCTCATCGATCACCGAAGGGGAGTTGTTCTACGGTCTTGCCAAGCGAGGCTATC
CGAAGGCGCTGTCGGAACGGATCCGCCAATTCCTGCTCCGGGTCGACGTTCTCCCTTGGGATCACGATGTCACGCGAACT
TATGGCGACCTGCGCGCTGCCTGTGACGCCAAAGGGGTGACTCTGGCGCCCCTCGATATGATGATTGCCGCTCATGCCGT
TGCAACTGCCGCAACCCTCGTCACGCGCGACAAGGCTTTTGCTCGCGTTTCGGAGCCTTTGAAGGTCGATGATTGGGCGA
ATGAAGGAAGCTGA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10198.39 Da        Isoelectric Point: 7.0179

>AT64365 WP_065280658.1 NZ_CP016286:c2428524-2428261 [Rhizobium leguminosarum]
MAKRTAKIFTTGRSQAVRLPAEFRFEESEVFVRRDPKSGDVILSRKPNSWDGLFELYGKDRVPEDFLGPDDRRQPSHDRD
PFEGWKE

Download         Length: 264 bp

>AT64365 NZ_CP016286:c2428524-2428261 [Rhizobium leguminosarum]
ATGGCAAAGAGAACAGCCAAGATTTTTACGACCGGCCGCAGCCAGGCAGTGAGGCTCCCTGCGGAGTTCCGCTTCGAGGA
GAGCGAGGTGTTCGTCCGTCGTGATCCGAAGTCCGGCGATGTCATTCTGTCACGCAAGCCGAATTCGTGGGATGGTCTCT
TTGAGCTTTATGGCAAGGATCGGGTTCCGGAAGATTTCCTGGGGCCAGACGACCGCCGCCAGCCTTCGCATGATCGTGAT
CCATTCGAGGGCTGGAAGGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B1C9P8

Antitoxin

Source ID Structure
AlphaFold DB A0A1B1C9H1

References