Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3139652..3140272 Replicon chromosome
Accession NZ_CP016273
Organism Yersinia pestis strain Cadman

Toxin (Protein)


Gene name Hha Uniprot ID Q66DR5
Locus tag BAY22_RS14440 Protein ID WP_002208622.1
Coordinates 3140069..3140272 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID Q66DR4
Locus tag BAY22_RS14435 Protein ID WP_002218472.1
Coordinates 3139652..3140020 (+) Length 123 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BAY22_RS14420 3137847..3138107 + 261 WP_002208617.1 type B 50S ribosomal protein L31 -
BAY22_RS14425 3138123..3138266 + 144 WP_002208618.1 type B 50S ribosomal protein L36 -
BAY22_RS14430 3139140..3139493 + 354 WP_002208619.1 hypothetical protein -
BAY22_RS14435 3139652..3140020 + 369 WP_002218472.1 Hha toxicity modulator TomB Antitoxin
BAY22_RS14440 3140069..3140272 + 204 WP_002208622.1 expression modulating protein YmoA Toxin
BAY22_RS14450 3141160..3141549 + 390 WP_002208623.1 MGMT family protein -
BAY22_RS14455 3141685..3142206 - 522 WP_002208624.1 lipoprotein -
BAY22_RS14460 3142463..3143323 + 861 WP_002208625.1 acyl-CoA thioesterase II -
BAY22_RS14465 3143583..3144872 - 1290 WP_002228344.1 ammonium transporter AmtB -
BAY22_RS14470 3144912..3145250 - 339 WP_002208627.1 P-II family nitrogen regulator -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(8-64)

Antitoxin

(1-118)


Sequences


Toxin        


Download         Length: 68 a.a.        Molecular weight: 8063.31 Da        Isoelectric Point: 6.4573

>T64359 WP_002208622.1 NZ_CP016273:3140069-3140272 [Yersinia pestis]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPPTVWQHVK

Download         Length: 204 bp

>T64359 NZ_CP016273:3140069-3140272 [Yersinia pestis]
ATGACAAAAACTGACTACCTGATGCGTTTAAGAAAATGTACGACTATCGATACGCTAGAACGTGTAATTGAAAAAAATAA
GTACGAACTTTCTGATGATGAACTGGAATTGTTTTACTCAGCTGCAGACCATCGCCTGGCTGAACTAACGATGAATAAGC
TTTATGATAAAATTCCACCTACTGTATGGCAACATGTGAAATAG

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14215.00 Da        Isoelectric Point: 4.6121

>AT64359 WP_002218472.1 NZ_CP016273:3139652-3140020 [Yersinia pestis]
MDEYSPKRHDIAQLKFLCESLYDEGIATLGDSHHGWINDPTSAINLQLNDLIEHIASFVMSFKIKYPDGSQLSELVEEYL
DDTYTLFSSYGINDPELRRWQKTKEHLFRLFSGEYVCTLMKT

Download         Length: 369 bp

>AT64359 NZ_CP016273:3139652-3140020 [Yersinia pestis]
ATGGATGAGTACTCGCCTAAGCGGCATGACATTGCCCAACTGAAGTTTCTATGTGAAAGCTTGTATGATGAAGGTATTGC
AACTCTTGGCGACAGCCATCATGGCTGGATAAATGACCCAACGTCGGCCATAAACCTTCAACTCAATGATTTGATCGAGC
ATATAGCTTCATTTGTGATGAGTTTTAAAATAAAATACCCGGATGGAAGCCAGCTTTCCGAGTTAGTGGAAGAATATTTA
GACGACACATATACTCTGTTTAGTAGTTATGGAATCAATGATCCTGAATTGCGTCGCTGGCAGAAAACCAAAGAGCATTT
ATTCAGACTTTTCTCAGGGGAATACGTATGTACCCTGATGAAAACTTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 2K5S


Antitoxin

Source ID Structure
AlphaFold DB Q66DR4

References