Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | Hha-TomB/- |
Location | 3139652..3140272 | Replicon | chromosome |
Accession | NZ_CP016273 | ||
Organism | Yersinia pestis strain Cadman |
Toxin (Protein)
Gene name | Hha | Uniprot ID | Q66DR5 |
Locus tag | BAY22_RS14440 | Protein ID | WP_002208622.1 |
Coordinates | 3140069..3140272 (+) | Length | 68 a.a. |
Antitoxin (Protein)
Gene name | TomB | Uniprot ID | Q66DR4 |
Locus tag | BAY22_RS14435 | Protein ID | WP_002218472.1 |
Coordinates | 3139652..3140020 (+) | Length | 123 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
BAY22_RS14420 | 3137847..3138107 | + | 261 | WP_002208617.1 | type B 50S ribosomal protein L31 | - |
BAY22_RS14425 | 3138123..3138266 | + | 144 | WP_002208618.1 | type B 50S ribosomal protein L36 | - |
BAY22_RS14430 | 3139140..3139493 | + | 354 | WP_002208619.1 | hypothetical protein | - |
BAY22_RS14435 | 3139652..3140020 | + | 369 | WP_002218472.1 | Hha toxicity modulator TomB | Antitoxin |
BAY22_RS14440 | 3140069..3140272 | + | 204 | WP_002208622.1 | expression modulating protein YmoA | Toxin |
BAY22_RS14450 | 3141160..3141549 | + | 390 | WP_002208623.1 | MGMT family protein | - |
BAY22_RS14455 | 3141685..3142206 | - | 522 | WP_002208624.1 | lipoprotein | - |
BAY22_RS14460 | 3142463..3143323 | + | 861 | WP_002208625.1 | acyl-CoA thioesterase II | - |
BAY22_RS14465 | 3143583..3144872 | - | 1290 | WP_002228344.1 | ammonium transporter AmtB | - |
BAY22_RS14470 | 3144912..3145250 | - | 339 | WP_002208627.1 | P-II family nitrogen regulator | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 68 a.a. Molecular weight: 8063.31 Da Isoelectric Point: 6.4573
>T64359 WP_002208622.1 NZ_CP016273:3140069-3140272 [Yersinia pestis]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPPTVWQHVK
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPPTVWQHVK
Download Length: 204 bp
>T64359 NZ_CP016273:3140069-3140272 [Yersinia pestis]
ATGACAAAAACTGACTACCTGATGCGTTTAAGAAAATGTACGACTATCGATACGCTAGAACGTGTAATTGAAAAAAATAA
GTACGAACTTTCTGATGATGAACTGGAATTGTTTTACTCAGCTGCAGACCATCGCCTGGCTGAACTAACGATGAATAAGC
TTTATGATAAAATTCCACCTACTGTATGGCAACATGTGAAATAG
ATGACAAAAACTGACTACCTGATGCGTTTAAGAAAATGTACGACTATCGATACGCTAGAACGTGTAATTGAAAAAAATAA
GTACGAACTTTCTGATGATGAACTGGAATTGTTTTACTCAGCTGCAGACCATCGCCTGGCTGAACTAACGATGAATAAGC
TTTATGATAAAATTCCACCTACTGTATGGCAACATGTGAAATAG
Antitoxin
Download Length: 123 a.a. Molecular weight: 14215.00 Da Isoelectric Point: 4.6121
>AT64359 WP_002218472.1 NZ_CP016273:3139652-3140020 [Yersinia pestis]
MDEYSPKRHDIAQLKFLCESLYDEGIATLGDSHHGWINDPTSAINLQLNDLIEHIASFVMSFKIKYPDGSQLSELVEEYL
DDTYTLFSSYGINDPELRRWQKTKEHLFRLFSGEYVCTLMKT
MDEYSPKRHDIAQLKFLCESLYDEGIATLGDSHHGWINDPTSAINLQLNDLIEHIASFVMSFKIKYPDGSQLSELVEEYL
DDTYTLFSSYGINDPELRRWQKTKEHLFRLFSGEYVCTLMKT
Download Length: 369 bp
>AT64359 NZ_CP016273:3139652-3140020 [Yersinia pestis]
ATGGATGAGTACTCGCCTAAGCGGCATGACATTGCCCAACTGAAGTTTCTATGTGAAAGCTTGTATGATGAAGGTATTGC
AACTCTTGGCGACAGCCATCATGGCTGGATAAATGACCCAACGTCGGCCATAAACCTTCAACTCAATGATTTGATCGAGC
ATATAGCTTCATTTGTGATGAGTTTTAAAATAAAATACCCGGATGGAAGCCAGCTTTCCGAGTTAGTGGAAGAATATTTA
GACGACACATATACTCTGTTTAGTAGTTATGGAATCAATGATCCTGAATTGCGTCGCTGGCAGAAAACCAAAGAGCATTT
ATTCAGACTTTTCTCAGGGGAATACGTATGTACCCTGATGAAAACTTAA
ATGGATGAGTACTCGCCTAAGCGGCATGACATTGCCCAACTGAAGTTTCTATGTGAAAGCTTGTATGATGAAGGTATTGC
AACTCTTGGCGACAGCCATCATGGCTGGATAAATGACCCAACGTCGGCCATAAACCTTCAACTCAATGATTTGATCGAGC
ATATAGCTTCATTTGTGATGAGTTTTAAAATAAAATACCCGGATGGAAGCCAGCTTTCCGAGTTAGTGGAAGAATATTTA
GACGACACATATACTCTGTTTAGTAGTTATGGAATCAATGATCCTGAATTGCGTCGCTGGCAGAAAACCAAAGAGCATTT
ATTCAGACTTTTCTCAGGGGAATACGTATGTACCCTGATGAAAACTTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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