Detailed information of TA system TA064358

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /COG5642-COG5654
• Location: 2282104..2283070
• Replicon: chromosome
• Accession: NZ_CP016273
• Organism: Yersinia pestis strain Cadman

Toxin (Protein)

• Gene name: -
• Uniprot ID: A0A0E8XJV6
• Locus tag: BAY22_RS10395
• Protein ID: WP_002210981.1
• Coordinates: 2282612..2283070 (+)
• Length: 153 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: Q66A69
• Locus tag: BAY22_RS10390
• Protein ID: WP_002210982.1
• Coordinates: 2282104..2282550 (+)
• Length: 149 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BAY22_RS10370	2277694..2278668	-	975	WP_002210985.1	L-Ala-D/L-Glu epimerase	-
BAY22_RS10375	2278831..2279334	+	504	WP_002210984.1	thiol peroxidase	-
BAY22_RS10380	2279587..2280045	+	459	WP_002213759.1	IS200/IS605-like element IS1541A family transposase	-
BAY22_RS10385	2280192..2281769	-	1578	WP_002210983.1	transcriptional regulator TyrR	-
BAY22_RS10390	2282104..2282550	+	447	WP_002210982.1	DUF2384 domain-containing protein	Antitoxin
BAY22_RS10395	2282612..2283070	+	459	WP_002210981.1	RES family NAD+ phosphorylase	Toxin
BAY22_RS10400	2283080..2284141	-	1062	WP_002210980.1	YcjF family protein	-
BAY22_RS10405	2284138..2285535	-	1398	WP_002210979.1	YcjX family protein	-
BAY22_RS10410	2285516..2285758	-	243	WP_002216375.1	phage shock protein PspD	-
BAY22_RS10415	2285843..2286202	-	360	WP_002210977.1	envelope stress response membrane protein PspC	-
BAY22_RS10420	2286202..2286429	-	228	WP_002210976.1	envelope stress response membrane protein PspB	-
BAY22_RS10425	2286591..2287256	-	666	WP_002210975.1	phage shock protein PspA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	2279587..2280045	458

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (2-147)

Antitoxin

• Antitoxin Xre (15-147)

Sequences

Toxin

Protein

• Length: 153 a.a.
• Molecular weight: 16994.38 Da
• Isoelectric Point: 4.8732

>T64358 WP_002210981.1 NZ_CP016273:2282612-2283070 [Yersinia pestis]
MTLYRIVMRRYLASAWTGYGAEIYGGRWNHKGHAAIYLASSISLAMLETLAHIQDSSTLSEFELFQIEISDSSIMLLQPQ
DWPTDWRSDPAPVATMDVGTEWLESESSVGLLVPSTLVPSENNLLVNPHHKDFPACLASVKPLSFVFDPRLK

Nucleotide

• Length: 459 bp

>T64358 NZ_CP016273:2282612-2283070 [Yersinia pestis]
ATGACGCTATACCGCATTGTTATGCGCCGCTATCTTGCATCGGCATGGACTGGTTACGGCGCTGAAATCTATGGTGGTCG
TTGGAATCATAAAGGCCATGCTGCCATCTATTTAGCCAGCAGTATTTCATTGGCTATGCTCGAAACACTGGCACATATTC
AGGACAGTTCAACACTCAGCGAATTTGAATTATTCCAAATTGAAATCAGTGACAGCAGTATTATGTTGCTACAGCCGCAG
GACTGGCCCACGGATTGGCGTAGCGATCCGGCACCGGTGGCAACGATGGATGTCGGCACCGAGTGGCTGGAATCAGAATC
CTCGGTAGGCTTACTGGTCCCGTCCACGTTGGTGCCGTCAGAAAACAACCTACTGGTCAATCCTCATCACAAAGATTTTC
CAGCGTGTTTGGCCAGCGTCAAACCGCTCTCTTTTGTCTTTGATCCACGGTTAAAATAG

Antitoxin

Protein

• Length: 149 a.a.
• Molecular weight: 16401.94 Da
• Isoelectric Point: 9.7155

>AT64358 WP_002210982.1 NZ_CP016273:2282104-2282550 [Yersinia pestis]
MRAYRPNPATKMGTLWREIGLPASRGTILVDSIKMGFSVDVIDSIHLWASMPKAEILRATGIPSRSLTRRRTHDGRFTPE
ESERIARFVRVMDAAVDLFGGDKGKAITWMSTPIKGLGYRSPDSLLETETGALEVCDLIGRLEHGVFT

Nucleotide

• Length: 447 bp

>AT64358 NZ_CP016273:2282104-2282550 [Yersinia pestis]
ATGAGAGCGTACCGCCCAAACCCCGCGACTAAAATGGGAACGCTTTGGCGTGAAATTGGCTTACCCGCCAGCCGCGGCAC
GATATTGGTCGATAGTATCAAAATGGGGTTTTCTGTTGATGTTATCGACAGCATTCATTTATGGGCATCCATGCCTAAAG
CTGAAATATTACGTGCTACCGGTATCCCCAGCCGTAGCCTGACTCGCCGCCGCACACATGATGGCCGTTTTACGCCTGAA
GAAAGCGAGAGAATCGCACGTTTTGTCCGCGTAATGGATGCCGCTGTCGATTTGTTCGGCGGCGATAAAGGTAAAGCCAT
TACCTGGATGTCCACGCCCATCAAAGGATTGGGGTACCGCAGCCCAGACTCCTTACTGGAAACCGAAACTGGCGCACTGG
AAGTGTGTGATTTGATTGGTCGTTTGGAACACGGCGTCTTTACTTAA

Structures

Toxin

• AlphaFold DB: A0A0E8XJV6

Antitoxin

• AlphaFold DB: A0A0E8XFL1