Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB-HicA
Location 1797185..1797831 Replicon chromosome
Accession NZ_CP016273
Organism Yersinia pestis strain Cadman

Toxin (Protein)


Gene name hicA Uniprot ID A0A3G5L3F2
Locus tag BAY22_RS07945 Protein ID WP_002214976.1
Coordinates 1797649..1797831 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0U1R391
Locus tag BAY22_RS07940 Protein ID WP_002211129.1
Coordinates 1797185..1797604 (-) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BAY22_RS07920 1792257..1793252 + 996 WP_002211125.1 substrate-binding domain-containing protein -
BAY22_RS07925 1793318..1794895 + 1578 WP_002211126.1 sugar ABC transporter ATP-binding protein -
BAY22_RS07930 1794898..1795919 + 1022 Protein_1514 ABC transporter permease -
BAY22_RS07935 1795968..1796927 + 960 WP_002211128.1 sugar kinase -
BAY22_RS07940 1797185..1797604 - 420 WP_002211129.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
BAY22_RS07945 1797649..1797831 - 183 WP_002214976.1 type II toxin-antitoxin system HicA family toxin Toxin
BAY22_RS07950 1798038..1798820 - 783 WP_002211130.1 flagellar type III secretion system protein FliR -
BAY22_RS07955 1798823..1799092 - 270 WP_002211131.1 flagellar biosynthesis protein FliQ -
BAY22_RS07960 1799198..1799938 - 741 WP_002220494.1 flagellar type III secretion system pore protein FliP -
BAY22_RS07965 1800019..1800555 - 537 WP_002211133.1 flagellar biosynthetic protein FliO -
BAY22_RS07970 1800555..1800971 - 417 WP_002211134.1 flagellar motor switch protein FliN -
BAY22_RS07975 1800968..1801969 - 1002 WP_002211135.1 flagellar motor switch protein FliM -
BAY22_RS07980 1801975..1802445 - 471 WP_002227961.1 flagellar basal body-associated protein FliL -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-131)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6783.99 Da        Isoelectric Point: 10.8877

>T64357 WP_002214976.1 NZ_CP016273:c1797831-1797649 [Yersinia pestis]
VKSSELIKLLETNGWKLMRVKGSHHQFKHPDFAAVITVPHPKKDVKPGTLRQILKDANLS

Download         Length: 183 bp

>T64357 NZ_CP016273:c1797831-1797649 [Yersinia pestis]
GTGAAAAGTTCGGAGCTGATAAAACTGCTCGAAACAAATGGTTGGAAGTTGATGAGAGTTAAAGGCAGTCATCATCAATT
CAAACATCCTGATTTCGCGGCAGTCATAACAGTACCGCATCCCAAAAAGGATGTTAAACCGGGAACCCTCCGGCAAATTC
TGAAAGATGCAAACCTTAGTTAA

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15549.42 Da        Isoelectric Point: 4.7731

>AT64357 WP_002211129.1 NZ_CP016273:c1797604-1797185 [Yersinia pestis]
MAIYPAYVHVDNDGSASGYFPDVKGCIFAINAGEDLFAEASSALDAHFEALVSEGIEIPEAHDMPYHVYRNPCDYADGGQ
WYNVNIDMSKYDGKVERINVTLPHRLIHQIDTIVKVRPEYASRSNFLAEAARKELQKLA

Download         Length: 420 bp

>AT64357 NZ_CP016273:c1797604-1797185 [Yersinia pestis]
ATGGCTATCTATCCCGCCTATGTTCACGTTGATAATGATGGCTCGGCAAGCGGTTATTTCCCCGATGTCAAAGGCTGTAT
TTTTGCCATCAATGCCGGGGAGGATTTATTTGCAGAAGCATCAAGCGCCCTGGATGCACACTTTGAAGCTTTGGTGTCTG
AAGGTATCGAAATTCCTGAAGCTCATGACATGCCTTACCACGTTTACCGTAACCCATGCGATTACGCTGATGGCGGACAG
TGGTATAACGTGAATATTGATATGTCGAAATATGATGGAAAAGTTGAACGAATTAACGTCACTCTTCCGCACCGGCTGAT
TCATCAAATCGATACTATTGTTAAAGTGCGTCCCGAGTATGCCAGCCGAAGCAATTTTCTAGCCGAAGCAGCACGTAAAG
AATTACAGAAATTGGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G5L3F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0U1R391

References