Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 2748325..2749790 Replicon chromosome
Accession NZ_CP016268
Organism Woeseia oceani strain XK5

Toxin (Protein)


Gene name HipA1 Uniprot ID A0A193LHG0
Locus tag BA177_RS12385 Protein ID WP_068616641.1
Coordinates 2748325..2749563 (-) Length 413 a.a.

Antitoxin (Protein)


Gene name HipB1 Uniprot ID A0A193LHM3
Locus tag BA177_RS12390 Protein ID WP_068616643.1
Coordinates 2749566..2749790 (-) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BA177_RS12355 2743883..2744752 + 870 WP_068616631.1 helix-turn-helix domain-containing protein -
BA177_RS12360 2744757..2745200 - 444 WP_068616633.1 hypothetical protein -
BA177_RS12365 2745202..2745619 - 418 Protein_2416 (2Fe-2S)-binding protein -
BA177_RS12370 2746133..2746750 + 618 WP_068616635.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein -
BA177_RS12375 2746855..2747613 + 759 WP_197493015.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
BA177_RS12380 2747626..2748228 - 603 WP_068616639.1 plasmid pRiA4b ORF-3 family protein -
BA177_RS12385 2748325..2749563 - 1239 WP_068616641.1 type II toxin-antitoxin system HipA family toxin Toxin
BA177_RS12390 2749566..2749790 - 225 WP_068616643.1 helix-turn-helix transcriptional regulator Antitoxin
BA177_RS12395 2750090..2750839 - 750 WP_068616645.1 metallophosphoesterase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-44)


Sequences

Toxin        


Download         Length: 413 a.a.        Molecular weight: 45678.13 Da        Isoelectric Point: 5.0437

>T64346 WP_068616641.1 NZ_CP016268:c2749563-2748325 [Woeseia oceani]
MARTLNVCYDRELVGQLSQDDGGQMTFRYDASWLGKREPIPLSRSLPLRDEPFTQKECQGVFGGLLPEEANRKVIARILG
ISDKNDFAMLEQIGGECAGAISFLPADETIPKDDNRYRQLDADELAKILRELPRRPLMAGEDGIRLSLAGAQDKLAVRVD
NEKISIPRGSAPSSHVLKPAIDTYEGVVFNEAFCMELARACDLNAAPVEIGKVEDIDYLLAERYDRIRGEEGKIRRLHQE
DFCQALGIRSEIKYQSEGGPSLGDCFALLRDASSAPAPDLIDLLDAVIFNLLIGNHDAHGKNFSLLYYPDRSIRLAPLYD
LVSTVFYPELTDRMAMKIGKQPKSALVYPNDVNQFAADAGLNAALVRARIPVLAGRLLQETPGIDKPHPISESVATLITE
RCKDYASRFSRK

Download         Length: 1239 bp

>T64346 NZ_CP016268:c2749563-2748325 [Woeseia oceani]
ATGGCTCGCACGCTCAATGTCTGTTATGACCGCGAACTTGTCGGCCAACTTTCACAGGACGACGGCGGGCAGATGACCTT
CCGGTACGATGCGTCCTGGCTCGGCAAGCGCGAACCGATCCCGCTGTCCCGGTCGCTGCCTTTGCGGGACGAGCCGTTCA
CGCAAAAAGAGTGTCAGGGGGTTTTTGGCGGGCTTCTGCCAGAGGAGGCCAATCGCAAGGTCATTGCTCGCATTCTTGGC
ATCAGTGACAAGAACGATTTCGCGATGCTCGAACAAATTGGCGGGGAGTGCGCTGGTGCAATCTCTTTTCTGCCGGCAGA
CGAGACAATCCCAAAAGATGATAATCGCTACCGTCAACTGGACGCTGACGAACTCGCCAAAATACTACGCGAGCTGCCGC
GCAGGCCACTTATGGCCGGCGAGGACGGTATTCGATTGTCACTTGCTGGTGCGCAGGACAAACTTGCCGTTCGTGTAGAT
AATGAAAAAATCTCCATACCGCGCGGCAGCGCACCGAGCTCACACGTTCTCAAACCGGCGATTGATACCTATGAAGGTGT
CGTCTTCAACGAGGCGTTCTGCATGGAACTGGCGCGCGCGTGCGACCTGAATGCGGCCCCCGTTGAGATTGGAAAAGTTG
AAGACATCGACTATCTGCTCGCCGAACGGTACGACCGTATCAGGGGAGAGGAAGGAAAAATCCGGCGACTTCACCAGGAA
GATTTTTGTCAGGCGCTCGGTATTCGCTCGGAGATCAAATACCAATCCGAAGGAGGACCGTCGCTGGGTGACTGTTTCGC
TTTGCTCCGGGATGCATCGAGCGCGCCGGCGCCTGATCTAATCGATTTGCTCGATGCGGTCATATTCAATTTGCTGATTG
GCAATCACGACGCGCACGGCAAGAACTTCTCGCTTCTTTATTACCCGGACCGGTCAATACGGCTTGCGCCGCTCTACGAT
CTTGTTTCGACCGTTTTCTACCCTGAACTAACTGACAGGATGGCAATGAAGATCGGCAAACAGCCCAAATCTGCGCTGGT
CTATCCGAATGACGTCAATCAATTTGCCGCTGACGCGGGCCTCAACGCGGCGCTGGTACGCGCGCGCATTCCGGTCCTGG
CGGGCAGATTGCTTCAGGAGACTCCCGGAATTGACAAGCCGCACCCAATCTCGGAGTCAGTCGCAACGTTGATTACGGAA
CGTTGTAAAGACTATGCATCGCGCTTCAGCAGAAAATAG

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 7786.10 Da        Isoelectric Point: 10.1064

>AT64346 WP_068616643.1 NZ_CP016268:c2749790-2749566 [Woeseia oceani]
MLSTAEDLGRLVKKERKALGLTQAELALTSGTGLRFISDLENGKPTCQIGKTLTVLKTLGIRLMTSSPDSPGVG

Download         Length: 225 bp

>AT64346 NZ_CP016268:c2749790-2749566 [Woeseia oceani]
ATGTTATCAACAGCGGAAGACTTGGGCAGGCTGGTCAAAAAAGAGCGCAAGGCGCTTGGCCTCACGCAAGCCGAACTCGC
CTTGACGTCCGGCACCGGCCTGCGCTTCATTAGCGACCTCGAAAACGGCAAACCCACTTGCCAGATCGGCAAGACGCTGA
CCGTTCTCAAGACACTGGGTATCCGCCTGATGACGTCTTCGCCCGATAGTCCCGGGGTAGGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A193LHG0

Antitoxin

Source ID Structure
AlphaFold DB A0A193LHM3

References