Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 2748325..2749790 Replicon chromosome
Accession NZ_CP016268
Organism Woeseia oceani strain XK5

Toxin (Protein)


Gene name HipA1 Uniprot ID A0A193LHG0
Locus tag BA177_RS12385 Protein ID WP_068616641.1
Coordinates 2748325..2749563 (-) Length 413 a.a.

Antitoxin (Protein)


Gene name HipB1 Uniprot ID A0A193LHM3
Locus tag BA177_RS12390 Protein ID WP_068616643.1
Coordinates 2749566..2749790 (-) Length 75 a.a.

Genomic Context

BA177_RS12355BA177_RS12370BA177_RS12375BA177_RS12360BA177_RS12365BA177_RS12380BA177_RS12385BA177_RS12390BA177_RS12395
Location: 2743883..2744752 (870 bp)
Type: Others
Protein ID: WP_068616631.1
Location: 2746133..2746750 (618 bp)
Type: Others
Protein ID: WP_068616635.1
Location: 2746855..2747613 (759 bp)
Type: Others
Protein ID: WP_197493015.1
Location: 2744757..2745200 (444 bp)
Type: Others
Protein ID: WP_068616633.1
Location: 2745202..2745619 (418 bp)
Type: Others
Protein ID: Protein_2416
Location: 2747626..2748228 (603 bp)
Type: Others
Protein ID: WP_068616639.1
Location: 2748325..2749563 (1239 bp)
Type: Toxin
Protein ID: WP_068616641.1
Location: 2749566..2749790 (225 bp)
Type: Antitoxin
Protein ID: WP_068616643.1
Location: 2750090..2750839 (750 bp)
Type: Others
Protein ID: WP_068616645.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
BA177_RS123552743883..2744752+870WP_068616631.1helix-turn-helix domain-containing protein-
BA177_RS123602744757..2745200-444WP_068616633.1hypothetical protein-
BA177_RS123652745202..2745619-418Protein_2416(2Fe-2S)-binding protein-
BA177_RS123702746133..2746750+618WP_068616635.1type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein-
BA177_RS123752746855..2747613+759WP_197493015.1nucleotidyl transferase AbiEii/AbiGii toxin family protein-
BA177_RS123802747626..2748228-603WP_068616639.1plasmid pRiA4b ORF-3 family protein-
BA177_RS123852748325..2749563-1239WP_068616641.1type II toxin-antitoxin system HipA family toxinToxin
BA177_RS123902749566..2749790-225WP_068616643.1helix-turn-helix transcriptional regulatorAntitoxin
BA177_RS123952750090..2750839-750WP_068616645.1metallophosphoesterase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-44)


Sequences

Toxin        


Download         Length: 413 a.a.        Molecular weight: 45678.13 Da        Isoelectric Point: 5.0437

>T64346 WP_068616641.1 NZ_CP016268:c2749563-2748325 [Woeseia oceani]
MARTLNVCYDRELVGQLSQDDGGQMTFRYDASWLGKREPIPLSRSLPLRDEPFTQKECQGVFGGLLPEEANRKVIARILG
ISDKNDFAMLEQIGGECAGAISFLPADETIPKDDNRYRQLDADELAKILRELPRRPLMAGEDGIRLSLAGAQDKLAVRVD
NEKISIPRGSAPSSHVLKPAIDTYEGVVFNEAFCMELARACDLNAAPVEIGKVEDIDYLLAERYDRIRGEEGKIRRLHQE
DFCQALGIRSEIKYQSEGGPSLGDCFALLRDASSAPAPDLIDLLDAVIFNLLIGNHDAHGKNFSLLYYPDRSIRLAPLYD
LVSTVFYPELTDRMAMKIGKQPKSALVYPNDVNQFAADAGLNAALVRARIPVLAGRLLQETPGIDKPHPISESVATLITE
RCKDYASRFSRK

Download         Length: 1239 bp

>T64346 NZ_CP016268:c2749563-2748325 [Woeseia oceani]
ATGGCTCGCACGCTCAATGTCTGTTATGACCGCGAACTTGTCGGCCAACTTTCACAGGACGACGGCGGGCAGATGACCTT
CCGGTACGATGCGTCCTGGCTCGGCAAGCGCGAACCGATCCCGCTGTCCCGGTCGCTGCCTTTGCGGGACGAGCCGTTCA
CGCAAAAAGAGTGTCAGGGGGTTTTTGGCGGGCTTCTGCCAGAGGAGGCCAATCGCAAGGTCATTGCTCGCATTCTTGGC
ATCAGTGACAAGAACGATTTCGCGATGCTCGAACAAATTGGCGGGGAGTGCGCTGGTGCAATCTCTTTTCTGCCGGCAGA
CGAGACAATCCCAAAAGATGATAATCGCTACCGTCAACTGGACGCTGACGAACTCGCCAAAATACTACGCGAGCTGCCGC
GCAGGCCACTTATGGCCGGCGAGGACGGTATTCGATTGTCACTTGCTGGTGCGCAGGACAAACTTGCCGTTCGTGTAGAT
AATGAAAAAATCTCCATACCGCGCGGCAGCGCACCGAGCTCACACGTTCTCAAACCGGCGATTGATACCTATGAAGGTGT
CGTCTTCAACGAGGCGTTCTGCATGGAACTGGCGCGCGCGTGCGACCTGAATGCGGCCCCCGTTGAGATTGGAAAAGTTG
AAGACATCGACTATCTGCTCGCCGAACGGTACGACCGTATCAGGGGAGAGGAAGGAAAAATCCGGCGACTTCACCAGGAA
GATTTTTGTCAGGCGCTCGGTATTCGCTCGGAGATCAAATACCAATCCGAAGGAGGACCGTCGCTGGGTGACTGTTTCGC
TTTGCTCCGGGATGCATCGAGCGCGCCGGCGCCTGATCTAATCGATTTGCTCGATGCGGTCATATTCAATTTGCTGATTG
GCAATCACGACGCGCACGGCAAGAACTTCTCGCTTCTTTATTACCCGGACCGGTCAATACGGCTTGCGCCGCTCTACGAT
CTTGTTTCGACCGTTTTCTACCCTGAACTAACTGACAGGATGGCAATGAAGATCGGCAAACAGCCCAAATCTGCGCTGGT
CTATCCGAATGACGTCAATCAATTTGCCGCTGACGCGGGCCTCAACGCGGCGCTGGTACGCGCGCGCATTCCGGTCCTGG
CGGGCAGATTGCTTCAGGAGACTCCCGGAATTGACAAGCCGCACCCAATCTCGGAGTCAGTCGCAACGTTGATTACGGAA
CGTTGTAAAGACTATGCATCGCGCTTCAGCAGAAAATAG

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 7786.10 Da        Isoelectric Point: 10.1064

>AT64346 WP_068616643.1 NZ_CP016268:c2749790-2749566 [Woeseia oceani]
MLSTAEDLGRLVKKERKALGLTQAELALTSGTGLRFISDLENGKPTCQIGKTLTVLKTLGIRLMTSSPDSPGVG

Download         Length: 225 bp

>AT64346 NZ_CP016268:c2749790-2749566 [Woeseia oceani]
ATGTTATCAACAGCGGAAGACTTGGGCAGGCTGGTCAAAAAAGAGCGCAAGGCGCTTGGCCTCACGCAAGCCGAACTCGC
CTTGACGTCCGGCACCGGCCTGCGCTTCATTAGCGACCTCGAAAACGGCAAACCCACTTGCCAGATCGGCAAGACGCTGA
CCGTTCTCAAGACACTGGGTATCCGCCTGATGACGTCTTCGCCCGATAGTCCCGGGGTAGGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A193LHG0

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A193LHM3

References