Detailed information of TA system TA064345

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): rlegTA/AbiEii-AbiEi
• Location: 2746133..2747613
• Replicon: chromosome
• Accession: NZ_CP016268
• Organism: Woeseia oceani strain XK5

Toxin (Protein)

• Gene name: rlegT
• Uniprot ID: -
• Locus tag: BA177_RS12375
• Protein ID: WP_197493015.1
• Coordinates: 2746855..2747613 (+)
• Length: 253 a.a.

Antitoxin (Protein)

• Gene name: rlegA
• Uniprot ID: A0A193LH80
• Locus tag: BA177_RS12370
• Protein ID: WP_068616635.1
• Coordinates: 2746133..2746750 (+)
• Length: 206 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BA177_RS12335	2741350..2741541	-	192	WP_068616628.1	hypothetical protein	-
BA177_RS12340	2741718..2742575	-	858	WP_068612111.1	IS3 family transposase	-
BA177_RS12345	2742572..2742838	-	267	WP_068612112.1	transposase	-
BA177_RS12350	2742927..2743331	+	405	WP_068616630.1	hypothetical protein	-
BA177_RS12355	2743883..2744752	+	870	WP_068616631.1	helix-turn-helix domain-containing protein	-
BA177_RS12360	2744757..2745200	-	444	WP_068616633.1	hypothetical protein	-
BA177_RS12365	2745202..2745619	-	418	Protein_2416	(2Fe-2S)-binding protein	-
BA177_RS12370	2746133..2746750	+	618	WP_068616635.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
BA177_RS12375	2746855..2747613	+	759	WP_197493015.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
BA177_RS12380	2747626..2748228	-	603	WP_068616639.1	plasmid pRiA4b ORF-3 family protein	-
BA177_RS12385	2748325..2749563	-	1239	WP_068616641.1	type II toxin-antitoxin system HipA family toxin	-
BA177_RS12390	2749566..2749790	-	225	WP_068616643.1	helix-turn-helix transcriptional regulator	-
BA177_RS12395	2750090..2750839	-	750	WP_068616645.1	metallophosphoesterase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (3-235)

Antitoxin

• Transcriptional regulator, AbiEi antitoxin (15-59)

Sequences

Toxin

Protein

• Length: 253 a.a.
• Molecular weight: 28251.41 Da
• Isoelectric Point: 4.6603

>T64345 WP_197493015.1 NZ_CP016268:2746855-2747613 [Woeseia oceani]
MERLLYRLSCSTHQGSFVLKGALLFRAWNVADGRATRDIDLLAFVDNAPENLSAIFREVCMIESEDGLVFDPDSIDARTI
KESADYEGVRIRFRGLLGTARINMQIDVGFGDIVHPRAATAGYPVILGLPAPTLRMYPPETVIAEKVEAMIHLGSLNSRM
KDFYDIWQLSQKLEFDPEVLSEAIRKTLKNRETEPIPFDELKANLLGNNAIEKQWSAFLEKSGVTGPDSFLEALDQIGIL
VGPLLERIDHLY

Nucleotide

• Length: 759 bp

>T64345 NZ_CP016268:2746855-2747613 [Woeseia oceani]
ATGGAACGTCTGCTGTATCGCTTGAGCTGCTCAACGCATCAGGGCTCGTTTGTCCTCAAGGGCGCCCTGCTGTTCAGGGC
ATGGAACGTAGCAGACGGTCGCGCGACGCGCGATATCGACTTGCTGGCGTTCGTCGATAACGCTCCCGAGAATCTCTCAG
CCATCTTTCGGGAGGTCTGCATGATTGAGAGCGAAGACGGCCTGGTCTTCGACCCGGATTCGATAGATGCAAGGACGATC
AAGGAGAGTGCCGACTACGAAGGCGTGCGTATCCGATTTCGAGGGCTACTTGGAACGGCAAGGATCAACATGCAGATCGA
TGTCGGCTTCGGCGACATAGTGCATCCTCGTGCTGCAACCGCCGGCTACCCCGTCATTCTCGGTCTGCCTGCCCCGACGC
TGCGCATGTATCCTCCCGAGACAGTTATTGCTGAGAAGGTCGAGGCTATGATCCATCTCGGTAGCCTGAACAGCCGAATG
AAGGATTTCTACGATATCTGGCAGCTCTCACAGAAACTGGAGTTTGATCCCGAAGTCCTGAGCGAGGCTATTCGGAAAAC
CCTGAAGAATCGTGAAACTGAACCGATACCTTTCGATGAGTTGAAAGCGAATCTGCTGGGAAACAATGCAATTGAAAAAC
AGTGGAGCGCGTTCCTCGAGAAGTCCGGCGTCACTGGCCCAGACTCATTTCTTGAAGCTCTTGATCAAATCGGGATCTTG
GTCGGCCCGCTGTTAGAACGCATCGACCATCTCTATTGA

Antitoxin

Protein

• Length: 206 a.a.
• Molecular weight: 23287.93 Da
• Isoelectric Point: 9.6771

>AT64345 WP_068616635.1 NZ_CP016268:2746133-2746750 [Woeseia oceani]
MPDPASNKQVDAARRVFQRGGGILRTREALDHGIHPRTLYAMRDEGLLERLDRGLYRLTDLPPLSDPDLVTAANKIPKGV
VCLISALHFHDITTQIPHAVSIAVSRGTEPPRLDYPPIRLYWFSGTAFSAGVQTHRIDNSQVRIYSAEKTLADCFKYRNK
IGMDTVLEALTLYRDQHKPKPQKLIEYARICRVEKVMRPYLEALL

Nucleotide

• Length: 618 bp

>AT64345 NZ_CP016268:2746133-2746750 [Woeseia oceani]
ATGCCTGACCCAGCAAGCAACAAGCAAGTCGACGCAGCTCGTCGTGTCTTTCAACGCGGCGGTGGAATTCTGCGCACACG
CGAAGCCCTGGATCACGGTATTCACCCTCGCACGCTATATGCCATGAGAGACGAGGGCCTGCTGGAACGCCTCGATCGAG
GACTCTACCGACTGACTGACCTGCCACCACTTTCAGATCCCGACCTGGTGACTGCGGCAAACAAGATACCCAAAGGGGTG
GTTTGCCTCATCTCGGCACTGCATTTCCACGACATCACGACCCAGATTCCGCATGCCGTATCGATCGCAGTGAGCAGGGG
GACAGAACCGCCACGGCTCGATTATCCGCCAATCCGGCTCTACTGGTTCTCCGGTACGGCATTTTCTGCTGGCGTACAAA
CCCACCGTATCGATAACTCACAGGTCCGGATCTACAGCGCAGAAAAGACCCTTGCGGACTGCTTCAAATACCGCAACAAG
ATCGGTATGGACACCGTGCTTGAAGCGCTGACTCTCTATCGGGATCAACACAAGCCAAAGCCTCAGAAGCTGATTGAGTA
CGCGAGAATTTGCCGGGTCGAGAAAGTGATGCGGCCATACCTGGAAGCACTGCTGTGA

Structures

Antitoxin

• AlphaFold DB: A0A193LH80