Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1940760..1942375 Replicon chromosome
Accession NZ_CP016268
Organism Woeseia oceani strain XK5

Toxin (Protein)


Gene name HipA3 Uniprot ID A0A193LFH0
Locus tag BA177_RS08605 Protein ID WP_068615420.1
Coordinates 1941074..1942375 (+) Length 434 a.a.

Antitoxin (Protein)


Gene name HipB3 Uniprot ID A0A193LFL7
Locus tag BA177_RS08600 Protein ID WP_068615417.1
Coordinates 1940760..1941080 (+) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BA177_RS08575 1936030..1936548 + 519 WP_068615409.1 cytochrome c -
BA177_RS08580 1936567..1937037 + 471 WP_068615411.1 DUF4442 domain-containing protein -
BA177_RS08585 1937170..1937454 + 285 WP_068615413.1 hypothetical protein -
BA177_RS08590 1937506..1939236 - 1731 WP_068615415.1 D-aminoacylase -
BA177_RS08595 1939270..1940520 - 1251 WP_197493395.1 dipeptidase -
BA177_RS08600 1940760..1941080 + 321 WP_068615417.1 helix-turn-helix domain-containing protein Antitoxin
BA177_RS08605 1941074..1942375 + 1302 WP_068615420.1 type II toxin-antitoxin system HipA family toxin Toxin
BA177_RS08610 1942628..1943323 + 696 WP_068615422.1 response regulator transcription factor -
BA177_RS08615 1943316..1944662 + 1347 WP_082989993.1 HAMP domain-containing histidine kinase -
BA177_RS08620 1944669..1946159 - 1491 WP_068615426.1 aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme -
BA177_RS08625 1946389..1947258 + 870 WP_068615428.1 SPFH domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(174-407)

Antitoxin

Cro/C1-type helix-turn-helix domain

(22-61)


Sequences

Toxin        


Download         Length: 434 a.a.        Molecular weight: 48465.98 Da        Isoelectric Point: 6.9139

>T64344 WP_068615420.1 NZ_CP016268:1941074-1942375 [Woeseia oceani]
MVTVDVAEVRLWGRAIGAVYWDDEAGLAAFEYTPAFQKSGIELSPLMMPLGSRVYRFPELARSSFKGLPGLLADSLPDDF
GNAIIDQWLVREGRDKASFNPVERLCYIGRRGMGALEFRPATRTTPKGSVPLEVEHLVELAQHILDLRDGLRIRLKGGAA
DYTEALDDILRVGTSAGGARAKAVIAWNPASGEIRSGQLNAPEGFEYWILKFDGVENRERGVRDPQGYGRIEYAYYLMAV
AAGITMSECRLLEENGRSHFMTRRFDRNTAGEKVHMQSLYALAHLDNQLPGAHSYEQAFQVMQTLRMAAPDISEQFRRMV
FNVVARNQDDHTKNIAYLMDKKGRWRLSPAFDMIYAWNPEGAWTRAHQMSVNGQRDRITLADISAVAEKYSVRNSQQIVE
QVLTACADWPTYAADAGVDSPASKRIGASFRTF

Download         Length: 1302 bp

>T64344 NZ_CP016268:1941074-1942375 [Woeseia oceani]
ATGGTAACGGTCGACGTTGCCGAAGTGCGTCTGTGGGGCCGGGCGATTGGTGCGGTGTATTGGGATGACGAGGCCGGGCT
TGCCGCTTTCGAATACACGCCGGCATTCCAAAAGAGCGGCATCGAGTTGTCACCGCTGATGATGCCATTAGGATCACGTG
TCTACCGTTTTCCAGAGCTCGCCAGGAGTTCTTTCAAGGGACTTCCCGGCCTGCTCGCTGATTCTCTGCCGGATGATTTT
GGCAATGCAATTATCGATCAATGGCTGGTGCGCGAAGGTCGCGACAAGGCGAGCTTCAACCCGGTCGAACGGCTTTGCTA
TATCGGCAGGCGTGGTATGGGCGCGCTCGAATTTCGCCCGGCAACACGCACGACACCGAAGGGCTCGGTCCCCTTGGAGG
TTGAGCACCTGGTTGAGCTGGCGCAGCACATTCTTGATCTCCGTGACGGCCTGCGCATCAGACTGAAAGGCGGTGCTGCC
GACTACACGGAAGCGCTGGACGACATTCTGCGCGTAGGTACGTCTGCTGGCGGCGCTCGTGCCAAAGCAGTAATTGCGTG
GAATCCGGCGAGCGGGGAAATTCGTTCCGGCCAGCTGAACGCGCCGGAAGGTTTCGAATACTGGATTCTCAAGTTTGATG
GTGTTGAGAATCGCGAGCGCGGTGTCCGCGATCCGCAGGGCTATGGCCGTATCGAATATGCGTACTATCTGATGGCTGTT
GCGGCCGGGATCACGATGAGCGAATGCCGGCTCCTCGAAGAAAACGGCCGCAGTCATTTCATGACGCGGCGGTTCGACCG
CAACACCGCTGGCGAAAAGGTCCATATGCAATCGCTCTACGCGCTGGCGCACCTGGACAATCAACTGCCCGGGGCGCACA
GCTATGAGCAGGCATTTCAGGTAATGCAGACGCTCAGGATGGCAGCACCAGACATTAGTGAGCAGTTTCGCCGCATGGTG
TTCAACGTGGTGGCGCGCAATCAGGACGATCACACCAAAAACATTGCCTACCTGATGGACAAAAAGGGTCGTTGGCGCTT
GTCTCCGGCATTCGACATGATCTACGCGTGGAATCCGGAGGGTGCCTGGACCCGCGCTCACCAGATGAGCGTTAATGGCC
AGCGCGACCGGATTACTCTCGCTGACATAAGCGCAGTCGCGGAGAAATATTCGGTACGTAATTCGCAGCAAATAGTCGAA
CAGGTACTAACGGCGTGTGCCGACTGGCCGACCTACGCAGCAGATGCCGGCGTCGATAGTCCTGCCAGTAAACGGATTGG
CGCCAGTTTCCGCACATTCTGA

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 11868.25 Da        Isoelectric Point: 7.0164

>AT64344 WP_068615417.1 NZ_CP016268:1940760-1941080 [Woeseia oceani]
MNNTDILAELGRRLRQRRLNVNLTQEALAAHAGVSLNTLRNAELGRNSSLDTLINLLRSLNALGQLQQLLPDEGPSPVEL
ARRDGRTRQRASTQAATQADEEEWQW

Download         Length: 321 bp

>AT64344 NZ_CP016268:1940760-1941080 [Woeseia oceani]
ATGAACAACACGGACATTCTTGCCGAACTGGGGCGTCGGCTGCGGCAGCGTCGGCTGAATGTCAACCTGACCCAGGAAGC
CCTGGCGGCGCACGCCGGTGTTTCATTGAACACGTTGCGCAATGCCGAACTCGGACGCAACAGTTCCCTGGATACGTTGA
TCAACCTGTTGCGTTCTCTGAATGCCCTTGGGCAGTTGCAGCAATTGTTGCCGGATGAGGGACCAAGCCCGGTAGAACTG
GCACGACGTGACGGGCGAACCCGGCAACGCGCTTCAACTCAGGCAGCAACGCAGGCTGACGAGGAAGAGTGGCAATGGTA
A

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A193LFH0

Antitoxin

Source ID Structure
AlphaFold DB A0A193LFL7

References