Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 306355..307935 Replicon chromosome
Accession NZ_CP016268
Organism Woeseia oceani strain XK5

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag BA177_RS01415 Protein ID WP_197493264.1
Coordinates 306355..307689 (-) Length 445 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag BA177_RS01420 Protein ID WP_197493265.1
Coordinates 307693..307935 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BA177_RS01375 301388..301921 + 534 WP_068618698.1 hypothetical protein -
BA177_RS01380 301918..302355 + 438 WP_068612076.1 hypothetical protein -
BA177_RS18480 302478..302630 + 153 WP_156762644.1 hypothetical protein -
BA177_RS01385 302817..303086 + 270 WP_068612079.1 hypothetical protein -
BA177_RS01390 303332..303604 - 273 WP_197493263.1 helix-turn-helix domain-containing protein -
BA177_RS01395 303868..304227 + 360 WP_156762645.1 hypothetical protein -
BA177_RS01400 304228..304479 - 252 WP_068612085.1 helix-turn-helix domain-containing protein -
BA177_RS01405 304562..305173 + 612 WP_068612087.1 sigma-70 family RNA polymerase sigma factor -
BA177_RS01410 305170..306192 + 1023 WP_068612090.1 FecR domain-containing protein -
BA177_RS01415 306355..307689 - 1335 WP_197493264.1 type II toxin-antitoxin system HipA family toxin Toxin
BA177_RS01420 307693..307935 - 243 WP_197493265.1 helix-turn-helix domain-containing protein Antitoxin
BA177_RS01425 308154..308633 + 480 WP_156762646.1 HipA domain-containing protein -
BA177_RS01430 308702..310024 - 1323 WP_068612096.1 HipA domain-containing protein -
BA177_RS01435 310021..310299 - 279 WP_197493266.1 helix-turn-helix domain-containing protein -
BA177_RS18485 310331..310486 + 156 WP_156762647.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(10-111)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-66)


Sequences

Toxin        


Download         Length: 445 a.a.        Molecular weight: 49146.91 Da        Isoelectric Point: 6.6183

>T64343 WP_197493264.1 NZ_CP016268:c307689-306355 [Woeseia oceani]
VARQSKSRRLGVWMNGELVGHWTIDATGQHEFRYAETWIAADETRPLSLSMPLQPADTPYRGDLVESFFDNLLPDSIDIR
RRVQARFGAASVSAFDLLFEVGRECVGAVQLLPPDNQPESIRQIDAEPLDEEGVAGELRAAISAAPLGQRDHDPFRISLA
GAQEKSALLLHQGQWHRPTGATPTTHIFKLPLGRVGNMQADLSTSVENEWLCRQIVHAFGIPAANCQIADFADQHVLIVE
RFDRRLARDKTWWIRLPQEDMCQATGSPAAARYEADGGPGIAAISSLLMGSQDAITERRVFFQTQVLFWMLCATDGHAKN
FSVFIGPRGRFSLTPSYDVISAYPILGSGRNQLAPQKAKLAMAVLGKNRHYRWAEIQPRHWLSTAREIGLKVTAEEDMLH
LGDHAPRVVEEVSAMLPGDFPKAVSEPIFDGLLRSAKKLAHIAG

Download         Length: 1335 bp

>T64343 NZ_CP016268:c307689-306355 [Woeseia oceani]
GTGGCGCGTCAATCCAAAAGTCGACGCCTGGGCGTATGGATGAACGGCGAGCTGGTGGGCCACTGGACCATCGACGCTAC
CGGGCAGCATGAGTTTCGTTATGCTGAGACATGGATTGCGGCCGACGAAACCCGCCCGCTATCACTGTCCATGCCATTGC
AACCCGCCGATACACCCTATCGCGGTGATCTCGTCGAATCCTTTTTCGACAATCTGTTGCCCGATAGCATCGACATCCGT
CGCCGCGTTCAGGCACGGTTTGGCGCCGCTTCTGTCTCTGCATTCGACCTGCTGTTTGAGGTAGGTCGGGAATGTGTCGG
CGCCGTGCAATTGCTGCCACCGGATAACCAACCGGAAAGCATCCGGCAAATTGATGCCGAACCGCTCGACGAGGAAGGCG
TCGCTGGCGAGTTGCGAGCCGCAATATCTGCGGCACCGCTCGGTCAGCGCGATCATGATCCGTTTCGCATTTCACTTGCT
GGCGCTCAGGAGAAATCGGCGCTGCTTTTGCATCAGGGCCAATGGCACCGCCCAACCGGGGCTACCCCAACCACGCACAT
CTTCAAACTGCCACTTGGCCGCGTCGGCAACATGCAGGCCGACCTGTCGACCTCGGTGGAAAACGAGTGGCTCTGCCGGC
AGATTGTCCACGCATTCGGGATTCCCGCCGCCAACTGCCAGATAGCCGATTTTGCAGATCAGCATGTATTGATTGTCGAG
CGTTTTGACCGCCGATTGGCCAGGGACAAGACGTGGTGGATCCGCTTGCCACAGGAAGACATGTGCCAGGCAACAGGCAG
CCCGGCCGCTGCTCGATACGAAGCCGATGGTGGGCCGGGTATCGCCGCTATATCCTCGCTGTTAATGGGCTCGCAGGACG
CGATTACTGAGCGGCGGGTCTTTTTCCAGACGCAGGTTCTGTTCTGGATGCTGTGCGCCACGGACGGGCACGCGAAGAAT
TTCAGCGTCTTCATCGGGCCACGTGGCCGTTTCTCGCTGACCCCGAGCTACGATGTGATTTCGGCATACCCGATCCTCGG
CAGCGGCAGGAACCAGCTCGCGCCGCAGAAAGCGAAACTGGCGATGGCCGTACTCGGCAAGAACAGGCACTACCGGTGGG
CAGAGATTCAGCCTCGGCACTGGCTATCAACTGCCCGGGAAATCGGCCTGAAAGTCACGGCGGAAGAAGACATGCTGCAC
CTTGGCGATCATGCGCCAAGGGTAGTTGAAGAAGTCTCCGCGATGCTGCCCGGTGATTTTCCTAAAGCGGTTTCTGAACC
AATTTTTGATGGGCTCTTGCGATCAGCGAAGAAGCTGGCTCATATCGCGGGTTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8985.43 Da        Isoelectric Point: 10.6143

>AT64343 WP_197493265.1 NZ_CP016268:c307935-307693 [Woeseia oceani]
VDYTIHTPRQLGQTLRGQRKSQKLTQKDAAKVVGLLPKTVSKLELAADTATVESLFKLLSALQLELVVRSRSPEVRDKEW

Download         Length: 243 bp

>AT64343 NZ_CP016268:c307935-307693 [Woeseia oceani]
GTGGACTACACAATACACACGCCAAGGCAGCTTGGCCAAACCCTTCGCGGGCAGCGCAAGTCGCAGAAGCTCACTCAGAA
GGACGCGGCAAAAGTGGTCGGCCTCTTGCCCAAGACGGTTTCGAAACTGGAACTCGCAGCTGACACCGCGACGGTCGAAA
GCCTTTTTAAATTGCTGTCGGCATTGCAACTGGAGCTCGTCGTGCGGTCCCGGTCACCCGAAGTCCGGGACAAGGAGTGG
TAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References