Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 2513018..2514740 Replicon chromosome
Accession NZ_CP016224
Organism Vibrio alginolyticus strain ZJ-T

Toxin (Protein)


Gene name mosT Uniprot ID D0FZT9
Locus tag BAU10_RS11360 Protein ID WP_000356587.1
Coordinates 2513018..2513956 (-) Length 313 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID A0A0M0HVB9
Locus tag BAU10_RS11365 Protein ID WP_002026815.1
Coordinates 2513949..2514740 (-) Length 264 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BAU10_RS11340 2508140..2508487 - 348 WP_008305502.1 hypothetical protein -
BAU10_RS11345 2508617..2509720 + 1104 WP_032479266.1 transposase -
BAU10_RS11350 2509783..2512194 - 2412 WP_008844786.1 type IV secretion system protein TraC -
BAU10_RS11355 2512194..2512886 - 693 WP_008305510.1 DsbC family protein -
BAU10_RS11360 2513018..2513956 - 939 WP_000356587.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
BAU10_RS11365 2513949..2514740 - 792 WP_002026815.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
BAU10_RS11370 2514960..2515346 - 387 WP_000180225.1 hypothetical protein -
BAU10_RS11375 2515343..2515915 - 573 WP_148532759.1 TraV family lipoprotein -
BAU10_RS11380 2515990..2517279 - 1290 WP_053410659.1 TraB/VirB10 family protein -
BAU10_RS11385 2517286..2518179 - 894 WP_053410672.1 type-F conjugative transfer system secretin TraK -
BAU10_RS11390 2518163..2518789 - 627 WP_000667170.1 hypothetical protein -
BAU10_RS11395 2518786..2519067 - 282 WP_000433891.1 type IV conjugative transfer system protein TraL -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2508617..2509720 1103
- flank IS/Tn - - 2519222..2520427 1205


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator AbiEi antitoxin, N-terminal domain

(1-97)


Sequences

Toxin        


Download         Length: 313 a.a.        Molecular weight: 35548.82 Da        Isoelectric Point: 4.9081

>T64342 WP_000356587.1 NZ_CP016224:c2513956-2513018 [Vibrio alginolyticus]
MDKDSPYYKQVSLLIRMLPVVATETVFALKGGTAINLFVRDFPRLSVDIDLAYLPLEPRDEALINVRAALQRITDRINTQ
PDIRAAFQDNKADELRIVVSSPVATIKIEVSPVARGTLHSAEIMPVQESVEDEFGYAEIQVVSLPDLYGGKLCAAMDRQH
PRDLFDVRMLLGSEGISREILVGFLTYTLSHPRPINEVMSPNWQPLNEKFQAEFDGMTFEKVECEDLASVRPMMLIELQK
HFTERDHAFLMSFKRGQPDWALFDYPNAADLPAIRWKLQNINKLAKNQAKHQEQLDKLKQVLDDWLVNANAE

Download         Length: 939 bp

>T64342 NZ_CP016224:c2513956-2513018 [Vibrio alginolyticus]
ATGGATAAAGATAGCCCATATTACAAACAGGTTTCCTTGCTCATAAGAATGCTTCCTGTGGTAGCAACAGAGACGGTTTT
TGCACTTAAAGGTGGCACCGCCATTAATTTATTTGTGAGAGATTTTCCTCGGCTATCTGTAGATATTGATCTTGCTTATC
TTCCACTTGAACCAAGAGATGAGGCTTTGATTAATGTCAGGGCTGCATTGCAGCGCATTACAGACAGAATCAATACTCAA
CCAGATATCAGAGCGGCATTTCAGGATAATAAAGCTGATGAACTGAGAATCGTTGTATCAAGTCCGGTTGCGACGATCAA
AATTGAAGTGTCGCCCGTCGCCAGAGGTACATTGCATAGTGCAGAAATAATGCCAGTTCAAGAGTCTGTTGAAGACGAGT
TTGGTTATGCTGAGATTCAGGTAGTCAGTCTTCCCGATCTGTATGGTGGGAAATTGTGTGCTGCAATGGATCGCCAACAT
CCTCGCGACTTATTTGATGTGCGTATGTTACTTGGCAGTGAAGGGATTTCGAGAGAGATTTTGGTGGGTTTTTTAACCTA
TACATTAAGTCACCCTCGGCCTATTAATGAAGTCATGTCGCCAAACTGGCAGCCTCTGAATGAGAAATTTCAGGCAGAAT
TTGACGGAATGACTTTTGAAAAAGTTGAATGCGAAGACTTAGCCTCTGTTAGGCCCATGATGTTAATTGAACTGCAAAAA
CATTTCACAGAAAGAGATCATGCTTTCCTTATGTCATTCAAAAGAGGGCAACCTGACTGGGCATTGTTTGACTATCCTAA
TGCAGCAGACTTGCCAGCGATTCGTTGGAAATTGCAGAACATTAACAAATTGGCAAAGAATCAAGCAAAACACCAAGAGC
AATTAGATAAATTGAAGCAAGTGCTTGATGATTGGCTTGTTAACGCAAACGCCGAGTAA

Antitoxin


Download         Length: 264 a.a.        Molecular weight: 30116.50 Da        Isoelectric Point: 9.1901

>AT64342 WP_002026815.1 NZ_CP016224:c2514740-2513949 [Vibrio alginolyticus]
MSSKINWLVAHTSPGALVLQQWLTENGVSYSLAQKYAQNGWLKKLCSGVYYRPDAQGDIKPTWVDAIQALDVQLGVSVHL
AGLSSLTHQGLSHYLQLNKEQVWICVKNKSSLPKWFREFPYQNWFYCGNHKLEVNPEKDLKRITVKEKELTVSCAELAAY
EVVDAIGKLISFEHVAELFQGLVNLSPRKVQDILERSSSVQANRIFLFLGRYYDHQWVNRIDETRIKLGAGKRQVVEKGR
FDERYQITVPEILSVKKGEQHNG

Download         Length: 792 bp

>AT64342 NZ_CP016224:c2514740-2513949 [Vibrio alginolyticus]
ATGTCATCTAAGATAAACTGGCTTGTTGCTCATACTTCTCCTGGTGCGCTAGTACTTCAGCAATGGCTGACTGAAAACGG
TGTGAGCTATTCCTTGGCTCAAAAGTACGCGCAGAACGGTTGGCTAAAGAAGCTATGTTCTGGCGTGTATTATCGTCCAG
ATGCGCAGGGCGATATAAAGCCAACTTGGGTTGATGCCATTCAAGCATTAGATGTGCAATTGGGCGTTTCAGTTCATTTG
GCTGGATTGAGCAGCTTAACTCACCAAGGACTGAGTCACTATTTACAGCTGAACAAAGAGCAAGTTTGGATTTGCGTTAA
AAATAAGTCGTCCTTACCAAAATGGTTTCGTGAATTCCCTTATCAGAATTGGTTTTACTGTGGAAATCATAAGCTTGAAG
TGAATCCCGAGAAAGATTTGAAAAGGATCACGGTTAAAGAGAAAGAACTCACTGTCAGCTGTGCAGAACTTGCTGCCTAT
GAAGTGGTAGACGCTATTGGGAAGCTGATTTCATTTGAGCATGTCGCAGAATTATTTCAGGGTTTAGTCAATCTTAGCCC
TAGAAAAGTACAAGATATTCTTGAGCGAAGCAGCTCTGTGCAGGCAAACCGAATATTTCTATTTCTGGGTCGATACTACG
ATCACCAGTGGGTCAATCGCATAGATGAAACAAGAATTAAATTGGGTGCAGGAAAGCGGCAGGTTGTCGAAAAAGGACGT
TTTGATGAGCGATATCAAATCACAGTGCCAGAGATATTAAGCGTCAAAAAAGGTGAACAACATAATGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1U9VZ44

Antitoxin

Source ID Structure
AlphaFold DB A0A0M0HVB9

References