Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 968424..969187 Replicon chromosome
Accession NZ_CP016224
Organism Vibrio alginolyticus strain ZJ-T

Toxin (Protein)


Gene name ataT Uniprot ID A0A6G7LPD4
Locus tag BAU10_RS04485 Protein ID WP_065274325.1
Coordinates 968424..968930 (-) Length 169 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID A0A501XZ00
Locus tag BAU10_RS04490 Protein ID WP_032481064.1
Coordinates 968921..969187 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BAU10_RS04450 963754..964044 - 291 WP_065274322.1 HigA family addiction module antidote protein -
BAU10_RS04455 964277..964558 + 282 WP_000433891.1 type IV conjugative transfer system protein TraL -
BAU10_RS04460 964555..965181 + 627 WP_000667170.1 hypothetical protein -
BAU10_RS04465 965165..966061 + 897 WP_065275059.1 type-F conjugative transfer system secretin TraK -
BAU10_RS04470 966064..967353 + 1290 WP_065274323.1 TraB/VirB10 family protein -
BAU10_RS04475 967428..968000 + 573 WP_162780823.1 TraV family lipoprotein -
BAU10_RS04480 967997..968383 + 387 WP_023584042.1 hypothetical protein -
BAU10_RS04485 968424..968930 - 507 WP_065274325.1 GNAT family N-acetyltransferase Toxin
BAU10_RS04490 968921..969187 - 267 WP_032481064.1 DUF1778 domain-containing protein Antitoxin
BAU10_RS04495 969556..970248 + 693 WP_065274326.1 DsbC family protein -
BAU10_RS04500 970249..972651 + 2403 WP_065274327.1 type IV secretion system protein TraC -
BAU10_RS04505 972644..972991 + 348 WP_065274328.1 plasmid-related protein -
BAU10_RS04510 973068..973487 + 420 WP_065275060.1 S26 family signal peptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(42-146)

Antitoxin

Vibrio phage ICP1, Orf50

(8-83)


Sequences

Toxin        


Download         Length: 169 a.a.        Molecular weight: 18247.98 Da        Isoelectric Point: 7.2132

>T64340 WP_065274325.1 NZ_CP016224:c968930-968424 [Vibrio alginolyticus]
MGISAPTLLADEHQINAFQCGIEELDTWLRKQALKSQKRGTARVYVVNDTDAHQVVGYYAIAMGSVSREQAFSSLRRNSP
DPIPMVILARLGVDNAYQGQGIAAGLLKDCIIRSVQAMNAVGGAGILVHAIDGSAQTFYKKFGFKESTFDPLVLMARICD
IEKSLSID

Download         Length: 507 bp

>T64340 NZ_CP016224:c968930-968424 [Vibrio alginolyticus]
TTGGGAATAAGCGCACCAACACTACTCGCTGATGAGCACCAAATTAATGCCTTTCAATGTGGCATCGAAGAACTCGATAC
CTGGTTAAGAAAACAGGCGTTAAAAAGTCAAAAACGGGGAACTGCGAGAGTGTATGTGGTCAATGACACTGACGCCCATC
AAGTGGTCGGGTACTATGCCATTGCCATGGGATCAGTTTCCAGAGAGCAAGCTTTTAGTTCATTAAGAAGAAATAGTCCA
GATCCCATTCCCATGGTGATTCTAGCCAGACTTGGAGTAGATAACGCCTATCAAGGTCAAGGCATTGCGGCAGGTCTTTT
AAAAGATTGTATCATTCGCTCAGTACAAGCAATGAACGCTGTCGGTGGAGCAGGAATCTTAGTCCATGCTATTGATGGTA
GTGCGCAAACGTTCTACAAGAAATTTGGCTTCAAAGAATCGACGTTTGATCCTTTAGTACTCATGGCAAGGATCTGCGAT
ATCGAAAAATCATTGTCGATAGACTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9941.46 Da        Isoelectric Point: 7.0146

>AT64340 WP_032481064.1 NZ_CP016224:c969187-968921 [Vibrio alginolyticus]
MATKTAPINMRVLPSVRDIIDAAASLKKVDRTVFIQQAALNEAHSILAEQRDFVLEAKAFEAFDNELRANPQTLEGMKDL
FKRKAPWE

Download         Length: 267 bp

>AT64340 NZ_CP016224:c969187-968921 [Vibrio alginolyticus]
ATGGCTACAAAGACAGCGCCAATCAACATGCGAGTACTGCCATCGGTAAGAGACATCATCGATGCCGCAGCAAGTTTAAA
AAAAGTCGATAGAACTGTATTCATTCAGCAGGCAGCGCTCAATGAAGCGCATAGTATACTGGCAGAACAGCGGGATTTTG
TTCTTGAAGCAAAGGCTTTTGAAGCGTTTGATAACGAACTTCGTGCAAATCCACAGACTCTTGAAGGCATGAAAGATCTG
TTTAAAAGGAAAGCGCCTTGGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6G7LPD4

Antitoxin

Source ID Structure
AlphaFold DB A0A501XZ00

References