Detailed information of TA system TA064338

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): slvAT/RES(toxin)
• Location: 153310..154226
• Replicon: plasmid pBM413
• Accession: NZ_CP016215
• Organism: Pseudomonas aeruginosa strain PA121617

Toxin (Protein)

• Gene name: slvT
• Uniprot ID: A0A2L1KI32
• Locus tag: A9P90_RS30175
• Protein ID: WP_019437783.1
• Coordinates: 153702..154226 (+)
• Length: 175 a.a.

Antitoxin (Protein)

• Gene name: slvA
• Uniprot ID: A0A2L1KH13
• Locus tag: A9P90_RS30170
• Protein ID: WP_019437782.1
• Coordinates: 153310..153705 (+)
• Length: 132 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A9P90_RS33420	148971..149495	-	525	WP_010794447.1	hypothetical protein	-
A9P90_RS30160	150389..150643	-	255	WP_021263738.1	hypothetical protein	-
A9P90_RS30165	150807..152726	+	1920	WP_021263737.1	hypothetical protein	-
A9P90_RS30170	153310..153705	+	396	WP_019437782.1	hypothetical protein	Antitoxin
A9P90_RS30175	153702..154226	+	525	WP_019437783.1	RES family NAD+ phosphorylase	Toxin
A9P90_RS30180	154272..155522	-	1251	WP_019437784.1	TerD family protein	-
A9P90_RS33425	155719..156774	-	1056	WP_139139567.1	prepilin-type N-terminal cleavage/methylation domain-containing protein	-
A9P90_RS30185	157149..157340	+	192	WP_019437785.1	hypothetical protein	-
A9P90_RS30195	157760..158905	-	1146	WP_021263240.1	glycerate kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	blaIMP-45 / blaOXA-1 / catB3 / qacE / sul1 / qnrVC6 / msr(E) / mph(E) / aph(3')-Ia	-	1..423017	423017

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (10-167)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 175 a.a.
• Molecular weight: 19052.57 Da
• Isoelectric Point: 4.5535

>T64338 WP_019437783.1 NZ_CP016215:153702-154226 [Pseudomonas aeruginosa]
MKIIGVQDLPCYRMHTPKWSVAPTSGAGAATQGGRVNRKGLEALYLSLESATAIAEFQQASAFLPPGLLISYSLSLDRVI
DFTGGYNDTWAPIWQDFFCDWRKIRFNDGVEPPSWIIGDLAIEADCAGILFESVANPGGRNLVLFTDQLPVHGNIVVNDP
RGDLPTDQSSWTRP

Nucleotide

• Length: 525 bp

>T64338 NZ_CP016215:153702-154226 [Pseudomonas aeruginosa]
ATGAAAATCATCGGAGTGCAGGACCTCCCCTGCTACCGAATGCACACTCCCAAGTGGTCCGTTGCGCCTACATCTGGAGC
TGGAGCTGCAACTCAGGGTGGCCGGGTTAACCGAAAGGGGCTAGAGGCTCTATACCTCTCGCTTGAGTCGGCAACGGCCA
TTGCTGAGTTTCAGCAAGCAAGCGCATTCCTTCCTCCTGGTCTGCTGATCAGCTATTCCCTCAGTCTGGATCGAGTGATC
GACTTCACCGGCGGCTATAACGATACCTGGGCCCCGATCTGGCAAGACTTCTTCTGCGACTGGAGAAAGATTCGCTTCAA
CGACGGCGTTGAGCCGCCGAGCTGGATTATCGGAGATCTGGCTATCGAGGCTGACTGTGCTGGGATTCTGTTCGAGTCCG
TTGCGAACCCTGGAGGTCGGAACCTGGTGCTTTTCACCGATCAGTTGCCGGTGCATGGGAATATTGTGGTCAACGATCCT
CGCGGGGATCTCCCTACCGACCAGTCATCTTGGACGCGCCCGTAG

Antitoxin

Protein

• Length: 132 a.a.
• Molecular weight: 14753.87 Da
• Isoelectric Point: 7.2048

>AT64338 WP_019437782.1 NZ_CP016215:153310-153705 [Pseudomonas aeruginosa]
MASKAVLELRPTNFAGLMDALKEVNRVMFSPERFLKVFSMDQQTLALRAHVHRNTVRNAPESEKVQAYIRDSVKVLRAVT
DMGTDVTNAIFWFKNEPLSTFGYKTAEEVVSEGKTEQLIAFLQSWEAGAQG

Nucleotide

• Length: 396 bp

>AT64338 NZ_CP016215:153310-153705 [Pseudomonas aeruginosa]
ATGGCCAGCAAAGCCGTATTAGAGCTTCGCCCCACCAACTTCGCGGGCTTGATGGACGCTCTCAAAGAGGTGAACCGTGT
GATGTTCTCTCCTGAGCGCTTCCTCAAGGTTTTTTCGATGGACCAGCAGACCTTGGCGCTCCGGGCCCATGTCCATCGCA
ACACTGTGCGCAACGCGCCTGAATCGGAAAAGGTCCAGGCCTACATTCGTGATTCAGTGAAGGTTCTGCGCGCAGTGACC
GACATGGGCACGGACGTGACGAATGCCATCTTCTGGTTTAAGAACGAGCCTCTTTCCACGTTCGGCTATAAGACCGCGGA
GGAAGTGGTCAGCGAAGGAAAAACCGAGCAGCTGATCGCTTTCCTTCAATCTTGGGAAGCTGGTGCCCAAGGATGA

Structures

Toxin

• AlphaFold DB: A0A2L1KI32

Antitoxin

• AlphaFold DB: A0A2L1KH13