Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 3357100..3357605 Replicon chromosome
Accession NZ_CP016214
Organism Pseudomonas aeruginosa strain PA121617

Toxin (Protein)


Gene name parE Uniprot ID A0A069QL22
Locus tag A9P90_RS15390 Protein ID WP_003121619.1
Coordinates 3357100..3357381 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q9I707
Locus tag A9P90_RS15395 Protein ID WP_003112628.1
Coordinates 3357378..3357605 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A9P90_RS15365 3352351..3353700 + 1350 WP_003119513.1 C4-dicarboxylate transporter DctA -
A9P90_RS15370 3353749..3354435 + 687 WP_003083762.1 FadR family transcriptional regulator -
A9P90_RS15375 3354536..3355270 + 735 WP_003117208.1 GntR family transcriptional regulator -
A9P90_RS15380 3355474..3355860 + 387 WP_014602345.1 aegerolysin family protein -
A9P90_RS15385 3355892..3356800 - 909 WP_016561475.1 LysR family transcriptional regulator -
A9P90_RS15390 3357100..3357381 - 282 WP_003121619.1 type II toxin-antitoxin system toxin ParE Toxin
A9P90_RS15395 3357378..3357605 - 228 WP_003112628.1 CopG family ribbon-helix-helix protein Antitoxin
A9P90_RS15400 3357781..3358401 - 621 WP_003101226.1 hypothetical protein -
A9P90_RS15405 3358502..3359002 + 501 WP_003112629.1 LEA type 2 family protein -
A9P90_RS15410 3359075..3359416 + 342 WP_003101229.1 alkylphosphonate utilization protein -
A9P90_RS15415 3359498..3360925 - 1428 WP_003083784.1 GABA permease -
A9P90_RS15420 3361094..3362587 - 1494 WP_003083788.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10492.22 Da        Isoelectric Point: 10.0435

>T64336 WP_003121619.1 NZ_CP016214:c3357381-3357100 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDTIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T64336 NZ_CP016214:c3357381-3357100 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACACCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTTCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8568.64 Da        Isoelectric Point: 5.5740

>AT64336 WP_003112628.1 NZ_CP016214:c3357605-3357378 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHIEIEKRWGLQ

Download         Length: 228 bp

>AT64336 NZ_CP016214:c3357605-3357378 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCCTACCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACATCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A069QL22

Antitoxin

Source ID Structure
PDB 6XRW
AlphaFold DB Q9I707

References