Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1360807..1362427 Replicon chromosome
Accession NZ_CP016210
Organism Azoarcus olearius strain DQS-4

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag dqs_RS06385 Protein ID WP_084018265.1
Coordinates 1360807..1362123 (-) Length 439 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag dqs_RS06390 Protein ID WP_065339971.1
Coordinates 1362167..1362427 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
dqs_RS06360 1356632..1357579 - 948 WP_065339966.1 allantoinase PuuE -
dqs_RS06365 1357600..1358127 - 528 WP_065339967.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
dqs_RS06370 1358164..1359357 - 1194 WP_065341657.1 urate hydroxylase PuuD -
dqs_RS06375 1359379..1359729 - 351 WP_065339968.1 hydroxyisourate hydrolase -
dqs_RS06380 1359843..1360802 - 960 WP_065339969.1 alpha/beta fold hydrolase -
dqs_RS06385 1360807..1362123 - 1317 WP_084018265.1 type II toxin-antitoxin system HipA family toxin Toxin
dqs_RS06390 1362167..1362427 - 261 WP_065339971.1 helix-turn-helix domain-containing protein Antitoxin
dqs_RS20445 1362741..1362815 + 75 WP_083831988.1 pyrroloquinoline quinone precursor peptide PqqA -
dqs_RS06395 1363032..1363946 + 915 WP_065339972.1 pyrroloquinoline quinone biosynthesis protein PqqB -
dqs_RS06400 1363982..1364773 + 792 WP_084018268.1 pyrroloquinoline-quinone synthase PqqC -
dqs_RS06405 1364952..1365218 + 267 WP_011764922.1 pyrroloquinoline quinone biosynthesis peptide chaperone PqqD -
dqs_RS06410 1365220..1366374 + 1155 WP_065339973.1 pyrroloquinoline quinone biosynthesis protein PqqE -
dqs_RS20690 1366705..1366881 - 177 WP_011764924.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(2-98)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-67)


Sequences

Toxin        


Download         Length: 439 a.a.        Molecular weight: 47875.75 Da        Isoelectric Point: 6.7666

>T64329 WP_084018265.1 NZ_CP016210:c1362123-1360807 [Azoarcus olearius]
MNGAFVGTWSVTPHAGEVLQYADDWVAAPQGRPLSLSLPFTPGNRPHRGEAVRAYFENLLPDSKEIRERIARRFHAGSTD
AFALLAEVGRDCAGALQILPEGAAPGGVQTVEATPLSEAEVARLLRNTVAQPALGGGEPAGDDALRISIAGAQEKTALLW
FEGRWCRPQGATPSTHIFKLPLGLVGNLQLDLRESVENEWLCSEILAAYGLPVARTQRLQFEDMKVLAVERFDRMWWEAA
DGKRWLVRLPQEDMCQATATPPHLKYEADGGPGVGRIMDLLATSREAERDRRLFFQAQLIFWMLWAPDGHAKNFSVFLRP
GGAYALTPLYDVLSAAPMLGEGAGKLSPFKVKMAMAVRSKNAHWRMQDILRRHWLAVGQRHGIVSADGRSAECVVDDLVS
RTPQVVQAVRGRLPADFPAALADSILDGLQAAADRLAA

Download         Length: 1317 bp

>T64329 NZ_CP016210:c1362123-1360807 [Azoarcus olearius]
ATGAACGGCGCCTTCGTCGGCACCTGGAGCGTCACGCCTCACGCCGGCGAAGTCCTGCAGTACGCCGACGACTGGGTGGC
CGCCCCGCAAGGGCGGCCGCTGTCGCTATCCCTTCCCTTCACCCCGGGCAATCGCCCGCACCGCGGCGAAGCCGTGCGGG
CCTACTTCGAGAACCTGCTGCCGGACAGCAAGGAGATCCGTGAGCGTATCGCGCGCCGCTTCCACGCCGGCTCGACCGAT
GCATTCGCCCTGCTGGCCGAAGTCGGCCGGGACTGTGCCGGCGCCCTACAGATCCTGCCTGAGGGCGCGGCGCCCGGCGG
AGTGCAGACGGTAGAAGCGACACCGCTGAGCGAGGCCGAGGTCGCCCGGTTGCTGCGCAACACCGTGGCCCAGCCCGCAC
TGGGCGGCGGGGAGCCGGCCGGCGACGACGCCTTGCGGATTTCCATTGCGGGCGCACAGGAAAAGACCGCGCTGCTGTGG
TTCGAGGGCCGCTGGTGCCGGCCCCAGGGTGCCACGCCCTCTACCCACATCTTCAAGCTGCCCCTGGGCCTGGTCGGCAA
CCTGCAGCTCGACCTGCGCGAGTCAGTGGAAAACGAGTGGCTGTGCTCGGAGATCCTGGCCGCCTATGGCCTGCCGGTGG
CGCGCACCCAGCGCCTGCAGTTCGAGGACATGAAAGTGCTGGCGGTGGAGCGGTTCGACCGGATGTGGTGGGAGGCTGCC
GACGGCAAACGCTGGCTTGTCCGTTTGCCGCAGGAAGACATGTGCCAGGCCACCGCCACGCCGCCCCACCTCAAGTACGA
AGCGGACGGCGGGCCCGGCGTGGGGCGCATCATGGACCTGCTGGCAACCTCGCGCGAAGCGGAGCGCGACCGGCGCCTGT
TCTTCCAAGCCCAGCTCATCTTCTGGATGCTGTGGGCGCCCGACGGCCATGCAAAGAACTTCAGCGTGTTCCTGCGTCCC
GGCGGTGCCTACGCACTCACGCCGCTGTACGACGTGCTCTCCGCGGCGCCGATGCTCGGCGAAGGCGCGGGCAAGCTGTC
GCCCTTCAAGGTGAAGATGGCGATGGCGGTGCGCTCGAAGAACGCGCACTGGCGCATGCAGGACATCCTGCGCCGGCACT
GGCTCGCTGTCGGTCAGCGCCACGGCATCGTCAGCGCCGACGGCCGCAGCGCAGAATGCGTCGTCGATGACCTCGTCTCC
CGCACGCCGCAGGTTGTGCAGGCCGTCCGCGGCAGGCTGCCTGCCGACTTTCCGGCGGCGCTCGCCGACAGCATCCTGGA
CGGCCTGCAAGCCGCCGCCGACAGACTTGCCGCTTAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9290.67 Da        Isoelectric Point: 8.9814

>AT64329 WP_065339971.1 NZ_CP016210:c1362427-1362167 [Azoarcus olearius]
MSDFTVRTAEQLPALLQGFRKQAGLTQAATAMRLGVTQQTLSALERNADKVSAARLLQLLSILDVELVLRPRDAAPTGET
PSSPTW

Download         Length: 261 bp

>AT64329 NZ_CP016210:c1362427-1362167 [Azoarcus olearius]
ATGTCCGACTTCACCGTCCGCACCGCGGAGCAGCTTCCCGCCCTGCTGCAGGGTTTCCGCAAGCAGGCTGGCTTGACCCA
GGCTGCCACCGCGATGCGCCTGGGGGTAACCCAGCAGACGCTGTCCGCCCTCGAACGCAATGCCGACAAGGTCAGTGCCG
CGCGGTTGCTGCAGTTGCTCAGCATCCTGGATGTCGAACTCGTCTTGCGCCCGCGCGACGCTGCGCCGACGGGTGAAACG
CCCTCCAGCCCGACCTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References