Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2147719..2148550 Replicon chromosome
Accession NZ_CP016182
Organism Escherichia coli strain EC590

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag BAY41_RS10705 Protein ID WP_000854814.1
Coordinates 2147719..2148093 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID B3Y195
Locus tag BAY41_RS10710 Protein ID WP_001285585.1
Coordinates 2148182..2148550 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BAY41_RS10670 2143115..2144281 + 1167 WP_000830163.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -
BAY41_RS10675 2144400..2144873 + 474 WP_001105393.1 DNA gyrase inhibitor SbmC -
BAY41_RS10680 2145071..2146129 + 1059 WP_001200905.1 FUSC family protein -
BAY41_RS10685 2146301..2146630 + 330 WP_000450409.1 DUF496 family protein -
BAY41_RS10690 2146731..2146913 - 183 WP_001016348.1 hypothetical protein -
BAY41_RS10695 2146967..2147113 + 147 Protein_1954 transposase domain-containing protein -
BAY41_RS24025 2147402..2147515 - 114 WP_001161660.1 DUF957 domain-containing protein -
BAY41_RS10700 2147528..2147722 - 195 WP_000988600.1 hypothetical protein -
BAY41_RS10705 2147719..2148093 - 375 WP_000854814.1 type IV toxin-antitoxin system toxin CbtA Toxin
BAY41_RS10710 2148182..2148550 - 369 WP_001285585.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
BAY41_RS10715 2148624..2148845 - 222 WP_000692323.1 DUF987 domain-containing protein -
BAY41_RS10720 2148908..2149384 - 477 WP_001186773.1 RadC family protein -
BAY41_RS10725 2149400..2149879 - 480 WP_000860076.1 antirestriction protein -
BAY41_RS10730 2149961..2150782 - 822 WP_001234530.1 DUF945 domain-containing protein -
BAY41_RS10740 2151003..2151413 - 411 WP_000846713.1 hypothetical protein -
BAY41_RS10745 2151429..2152112 - 684 WP_000775500.1 hypothetical protein -
BAY41_RS10750 2152248..2153318 - 1071 WP_000102643.1 patatin-like phospholipase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T64311 WP_000854814.1 NZ_CP016182:c2148093-2147719 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T64311 NZ_CP016182:c2148093-2147719 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13593.48 Da        Isoelectric Point: 6.3139

>AT64311 WP_001285585.1 NZ_CP016182:c2148550-2148182 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT64311 NZ_CP016182:c2148550-2148182 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LW60

References