Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 731848..733394 Replicon chromosome
Accession NZ_CP016180
Organism Pasteurella skyensis strain 95A1

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag A6B44_RS03395 Protein ID WP_090922455.1
Coordinates 732081..733394 (+) Length 438 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag A6B44_RS03390 Protein ID WP_090922457.1
Coordinates 731848..732087 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A6B44_RS03375 727674..728903 + 1230 WP_090922463.1 aromatic amino acid transporter -
A6B44_RS03380 729004..730293 - 1290 WP_090922461.1 isochorismate synthase -
A6B44_RS03385 730466..731683 + 1218 WP_090922459.1 pyridoxal phosphate-dependent aminotransferase -
A6B44_RS03390 731848..732087 + 240 WP_090922457.1 helix-turn-helix domain-containing protein Antitoxin
A6B44_RS03395 732081..733394 + 1314 WP_090922455.1 HipA domain-containing protein Toxin
A6B44_RS03400 733419..734537 + 1119 WP_090922452.1 hypothetical protein -
A6B44_RS03405 734602..734949 + 348 WP_176673456.1 tRNA-binding protein -
A6B44_RS03410 734992..735426 + 435 WP_090922448.1 hypothetical protein -
A6B44_RS03415 735444..736244 + 801 WP_090922445.1 hypothetical protein -
A6B44_RS03420 736974..737399 + 426 WP_090922443.1 hypothetical protein -
A6B44_RS03425 737392..737832 + 441 WP_090922441.1 MarR family transcriptional regulator -
A6B44_RS03430 737937..738251 - 315 WP_090922439.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-104)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-67)


Sequences

Toxin        


Download         Length: 438 a.a.        Molecular weight: 49573.77 Da        Isoelectric Point: 7.7494

>T64304 WP_090922455.1 NZ_CP016180:732081-733394 [Pasteurella skyensis]
MVTRLNVFMNGESVGVFTRTSAGAYYFSYVESWFNSPQCRPISLSMPLRFEAYQGKEVINFFDNLLPDNPQIRERIATRF
QAETKQPFDLLAKIGRDATGAITLLPEGDELSDYKTIQAEVLNETRLAEIIQGYQQNAPLGMLDSTQDFRISIAGAQEKT
ALLFHNNQWQLPQGLTPTTHIIKLPIGEIKTAKHTLDLSKSVDNELICLKLCQAFGLNTAESDLLTVRDLKVLAVKRFDR
RLASSNDYYLRLPHEDFCQVFGLSSAQKYENDGGVGIKEIMQKLLYSNDTNDRHSFMQTQFIFWLLGAIDGHSKNFSVAI
ERQGRYRLSPVYDVISAYPMLGVRGWHKRDLQLAMSLSSTKKGKKWYWHSIRAEHYLTTAKIVGFSPNVMKQSIEYICDT
AQQTIDKVGNELPVMIDETVRDQIFTGVLKAVGKVVI

Download         Length: 1314 bp

>T64304 NZ_CP016180:732081-733394 [Pasteurella skyensis]
ATGGTAACTCGTCTTAATGTCTTTATGAATGGAGAGTCTGTTGGAGTGTTTACACGAACTTCAGCAGGCGCTTATTATTT
TAGCTATGTTGAAAGCTGGTTCAATAGCCCACAATGTCGCCCCATTTCGCTTTCAATGCCACTACGTTTTGAAGCCTATC
AAGGAAAAGAGGTGATCAATTTCTTTGATAACTTACTCCCTGATAATCCACAAATTCGTGAACGAATAGCCACACGCTTT
CAAGCAGAAACCAAACAACCTTTTGATTTATTGGCAAAGATTGGTCGGGATGCTACAGGTGCAATTACCCTTTTACCTGA
AGGTGATGAATTATCCGACTACAAAACTATTCAGGCTGAAGTATTAAATGAAACACGTCTTGCAGAAATTATACAGGGCT
ACCAACAAAATGCGCCACTTGGTATGTTAGACAGTACACAAGATTTCCGCATTTCTATTGCAGGTGCACAAGAAAAAACC
GCACTATTATTTCACAATAATCAGTGGCAGTTACCGCAAGGTTTAACACCTACCACACATATTATTAAGTTACCTATTGG
TGAAATTAAAACTGCAAAACATACACTAGACTTGTCGAAAAGTGTAGATAATGAATTGATTTGTTTAAAACTGTGTCAAG
CATTTGGTTTGAATACCGCAGAGAGTGATTTACTTACAGTGAGAGATTTGAAAGTACTCGCAGTAAAACGTTTTGACCGT
CGTTTAGCTAGTTCAAATGACTATTATTTACGTTTGCCTCACGAAGATTTTTGTCAGGTTTTTGGATTATCTTCAGCACA
AAAATACGAAAATGACGGTGGAGTCGGTATTAAAGAGATTATGCAAAAATTACTTTATTCTAATGATACTAACGACCGTC
ATTCATTTATGCAAACACAATTTATTTTTTGGTTATTAGGGGCTATTGATGGACATTCAAAAAATTTTTCAGTAGCTATT
GAACGACAAGGGCGTTATCGTTTATCCCCTGTATATGATGTTATTTCCGCTTATCCAATGCTTGGAGTTAGAGGTTGGCA
CAAACGTGATTTACAACTGGCTATGAGTTTAAGTAGTACAAAAAAAGGTAAAAAATGGTATTGGCATAGTATTCGAGCAG
AACACTATTTGACTACAGCAAAAATAGTAGGTTTTAGTCCAAACGTAATGAAGCAAAGTATTGAGTATATTTGTGATACA
GCACAACAAACTATTGATAAAGTAGGTAATGAATTACCTGTTATGATTGATGAAACAGTACGTGACCAAATTTTTACTGG
TGTTTTAAAAGCAGTAGGAAAAGTGGTGATATAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9031.48 Da        Isoelectric Point: 5.7928

>AT64304 WP_090922457.1 NZ_CP016180:731848-732087 [Pasteurella skyensis]
MVIITPQMLAVYLKDYRKQKNLTQAEVANQVGLRQATISDFEKNPNKVTIETFFKIVTALGLEIHLLPKSENEEGVDIW

Download         Length: 240 bp

>AT64304 NZ_CP016180:731848-732087 [Pasteurella skyensis]
ATGGTGATCATCACTCCACAAATGCTTGCGGTTTATTTGAAAGATTATCGTAAACAGAAGAACTTGACTCAAGCTGAAGT
TGCCAATCAGGTTGGTTTACGGCAGGCTACCATTTCAGATTTTGAGAAAAACCCTAATAAGGTTACGATTGAAACATTCT
TCAAAATTGTGACGGCACTGGGACTGGAAATTCATCTACTGCCAAAATCAGAGAATGAAGAGGGAGTAGATATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References