Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 1205843..1206371 Replicon chromosome
Accession NZ_CP016178
Organism Vibrio breoganii strain FF50

Toxin (Protein)


Gene name relE Uniprot ID A0A193KI67
Locus tag A6E01_RS18235 Protein ID WP_017028226.1
Coordinates 1206081..1206371 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A193KIL6
Locus tag A6E01_RS18230 Protein ID WP_017028225.1
Coordinates 1205843..1206091 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A6E01_RS18195 1201325..1201648 - 324 WP_017028219.1 hypothetical protein -
A6E01_RS18200 1201638..1202144 - 507 WP_017028220.1 DMT family transporter -
A6E01_RS18205 1202141..1202584 - 444 WP_017028221.1 DMT family transporter -
A6E01_RS18210 1202581..1203096 - 516 WP_017028222.1 VOC family protein -
A6E01_RS18215 1203096..1203455 - 360 WP_065210943.1 carboxymuconolactone decarboxylase family protein -
A6E01_RS18220 1203748..1204656 - 909 WP_017027019.1 IS5 family transposase -
A6E01_RS18225 1204849..1205538 - 690 WP_065210944.1 zinc metallopeptidase -
A6E01_RS18230 1205843..1206091 + 249 WP_017028225.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
A6E01_RS18235 1206081..1206371 + 291 WP_017028226.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A6E01_RS18240 1206463..1206936 - 474 WP_065210945.1 hypothetical protein -
A6E01_RS18245 1207587..1208879 - 1293 WP_017028228.1 DEAD/DEAH box helicase -
A6E01_RS18250 1209332..1209775 - 444 WP_065210946.1 MarR family transcriptional regulator -
A6E01_RS18255 1209899..1210321 + 423 WP_017028230.1 organic hydroperoxide resistance protein -
A6E01_RS18260 1210393..1211322 + 930 WP_065210947.1 NADP-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1203748..1204656 908


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(12-75)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11196.21 Da        Isoelectric Point: 10.8028

>T64301 WP_017028226.1 NZ_CP016178:1206081-1206371 [Vibrio breoganii]
MTFKLNFKKSALKEWKKLGSTLQQQFKKKLIERLDNPHVPASRLSGAENIYKIKLRQSGYRLVYKVEDDVVIVTVLAVGK
RERSDVYVKAMKRLDN

Download         Length: 291 bp

>T64301 NZ_CP016178:1206081-1206371 [Vibrio breoganii]
ATGACCTTTAAACTCAACTTTAAAAAGAGCGCACTCAAAGAGTGGAAAAAGCTTGGTTCAACATTACAACAACAATTTAA
GAAAAAGCTAATCGAGCGCTTAGACAACCCACATGTTCCGGCGTCAAGACTTTCTGGAGCTGAAAACATATATAAAATTA
AGCTGCGTCAATCAGGCTACCGTCTCGTCTACAAAGTTGAAGACGATGTCGTCATTGTAACCGTCTTAGCAGTAGGAAAA
CGAGAACGAAGCGATGTTTACGTTAAAGCTATGAAAAGGTTAGATAATTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9061.33 Da        Isoelectric Point: 3.9610

>AT64301 WP_017028225.1 NZ_CP016178:1205843-1206091 [Vibrio breoganii]
MTTRILADVAASITELKANPMKVATSAYGEPVAVLNRNEPAFYCVPAEAYEMMIDRLEDLELLAIAKERESEESISVNID
DL

Download         Length: 249 bp

>AT64301 NZ_CP016178:1205843-1206091 [Vibrio breoganii]
ATGACCACTAGAATTTTAGCTGATGTTGCCGCAAGCATCACTGAGTTGAAAGCTAACCCTATGAAAGTTGCAACTAGTGC
TTATGGCGAACCTGTCGCTGTACTAAACCGAAATGAACCAGCATTCTATTGCGTACCTGCCGAAGCGTACGAAATGATGA
TAGACAGACTCGAAGATCTTGAACTACTAGCTATTGCTAAAGAGCGTGAATCTGAAGAGAGCATTTCGGTAAATATTGAT
GACCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A193KI67

Antitoxin

Source ID Structure
AlphaFold DB A0A193KIL6

References