Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relBE/ParE-YafN |
Location | 1205843..1206371 | Replicon | chromosome |
Accession | NZ_CP016178 | ||
Organism | Vibrio breoganii strain FF50 |
Toxin (Protein)
Gene name | relE | Uniprot ID | A0A193KI67 |
Locus tag | A6E01_RS18235 | Protein ID | WP_017028226.1 |
Coordinates | 1206081..1206371 (+) | Length | 97 a.a. |
Antitoxin (Protein)
Gene name | relB | Uniprot ID | A0A193KIL6 |
Locus tag | A6E01_RS18230 | Protein ID | WP_017028225.1 |
Coordinates | 1205843..1206091 (+) | Length | 83 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
A6E01_RS18195 | 1201325..1201648 | - | 324 | WP_017028219.1 | hypothetical protein | - |
A6E01_RS18200 | 1201638..1202144 | - | 507 | WP_017028220.1 | DMT family transporter | - |
A6E01_RS18205 | 1202141..1202584 | - | 444 | WP_017028221.1 | DMT family transporter | - |
A6E01_RS18210 | 1202581..1203096 | - | 516 | WP_017028222.1 | VOC family protein | - |
A6E01_RS18215 | 1203096..1203455 | - | 360 | WP_065210943.1 | carboxymuconolactone decarboxylase family protein | - |
A6E01_RS18220 | 1203748..1204656 | - | 909 | WP_017027019.1 | IS5 family transposase | - |
A6E01_RS18225 | 1204849..1205538 | - | 690 | WP_065210944.1 | zinc metallopeptidase | - |
A6E01_RS18230 | 1205843..1206091 | + | 249 | WP_017028225.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
A6E01_RS18235 | 1206081..1206371 | + | 291 | WP_017028226.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
A6E01_RS18240 | 1206463..1206936 | - | 474 | WP_065210945.1 | hypothetical protein | - |
A6E01_RS18245 | 1207587..1208879 | - | 1293 | WP_017028228.1 | DEAD/DEAH box helicase | - |
A6E01_RS18250 | 1209332..1209775 | - | 444 | WP_065210946.1 | MarR family transcriptional regulator | - |
A6E01_RS18255 | 1209899..1210321 | + | 423 | WP_017028230.1 | organic hydroperoxide resistance protein | - |
A6E01_RS18260 | 1210393..1211322 | + | 930 | WP_065210947.1 | NADP-dependent oxidoreductase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | flank | IS/Tn | - | - | 1203748..1204656 | 908 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 97 a.a. Molecular weight: 11196.21 Da Isoelectric Point: 10.8028
>T64301 WP_017028226.1 NZ_CP016178:1206081-1206371 [Vibrio breoganii]
MTFKLNFKKSALKEWKKLGSTLQQQFKKKLIERLDNPHVPASRLSGAENIYKIKLRQSGYRLVYKVEDDVVIVTVLAVGK
RERSDVYVKAMKRLDN
MTFKLNFKKSALKEWKKLGSTLQQQFKKKLIERLDNPHVPASRLSGAENIYKIKLRQSGYRLVYKVEDDVVIVTVLAVGK
RERSDVYVKAMKRLDN
Download Length: 291 bp
>T64301 NZ_CP016178:1206081-1206371 [Vibrio breoganii]
ATGACCTTTAAACTCAACTTTAAAAAGAGCGCACTCAAAGAGTGGAAAAAGCTTGGTTCAACATTACAACAACAATTTAA
GAAAAAGCTAATCGAGCGCTTAGACAACCCACATGTTCCGGCGTCAAGACTTTCTGGAGCTGAAAACATATATAAAATTA
AGCTGCGTCAATCAGGCTACCGTCTCGTCTACAAAGTTGAAGACGATGTCGTCATTGTAACCGTCTTAGCAGTAGGAAAA
CGAGAACGAAGCGATGTTTACGTTAAAGCTATGAAAAGGTTAGATAATTGA
ATGACCTTTAAACTCAACTTTAAAAAGAGCGCACTCAAAGAGTGGAAAAAGCTTGGTTCAACATTACAACAACAATTTAA
GAAAAAGCTAATCGAGCGCTTAGACAACCCACATGTTCCGGCGTCAAGACTTTCTGGAGCTGAAAACATATATAAAATTA
AGCTGCGTCAATCAGGCTACCGTCTCGTCTACAAAGTTGAAGACGATGTCGTCATTGTAACCGTCTTAGCAGTAGGAAAA
CGAGAACGAAGCGATGTTTACGTTAAAGCTATGAAAAGGTTAGATAATTGA
Antitoxin
Download Length: 83 a.a. Molecular weight: 9061.33 Da Isoelectric Point: 3.9610
>AT64301 WP_017028225.1 NZ_CP016178:1205843-1206091 [Vibrio breoganii]
MTTRILADVAASITELKANPMKVATSAYGEPVAVLNRNEPAFYCVPAEAYEMMIDRLEDLELLAIAKERESEESISVNID
DL
MTTRILADVAASITELKANPMKVATSAYGEPVAVLNRNEPAFYCVPAEAYEMMIDRLEDLELLAIAKERESEESISVNID
DL
Download Length: 249 bp
>AT64301 NZ_CP016178:1205843-1206091 [Vibrio breoganii]
ATGACCACTAGAATTTTAGCTGATGTTGCCGCAAGCATCACTGAGTTGAAAGCTAACCCTATGAAAGTTGCAACTAGTGC
TTATGGCGAACCTGTCGCTGTACTAAACCGAAATGAACCAGCATTCTATTGCGTACCTGCCGAAGCGTACGAAATGATGA
TAGACAGACTCGAAGATCTTGAACTACTAGCTATTGCTAAAGAGCGTGAATCTGAAGAGAGCATTTCGGTAAATATTGAT
GACCTTTAA
ATGACCACTAGAATTTTAGCTGATGTTGCCGCAAGCATCACTGAGTTGAAAGCTAACCCTATGAAAGTTGCAACTAGTGC
TTATGGCGAACCTGTCGCTGTACTAAACCGAAATGAACCAGCATTCTATTGCGTACCTGCCGAAGCGTACGAAATGATGA
TAGACAGACTCGAAGATCTTGAACTACTAGCTATTGCTAAAGAGCGTGAATCTGAAGAGAGCATTTCGGTAAATATTGAT
GACCTTTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A193KI67 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A193KIL6 |