64300

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) sdenTA/AbiEii(toxin)
Location 993165..994585 Replicon chromosome
Accession NZ_CP016178
Organism Vibrio breoganii strain FF50

Toxin (Protein)


Gene name sdenT Uniprot ID A0A193KI30
Locus tag A6E01_RS17375 Protein ID WP_065210842.1
Coordinates 993165..994052 (-) Length 296 a.a.

Antitoxin (Protein)


Gene name sdenA Uniprot ID A0A193KI56
Locus tag A6E01_RS17380 Protein ID WP_017029554.1
Coordinates 994052..994585 (-) Length 178 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A6E01_RS21055 988447..988662 - 216 WP_198596487.1 transposase -
A6E01_RS21060 988704..989737 + 1034 WP_167714333.1 IS630 family transposase -
A6E01_RS17350 989950..990477 + 528 WP_065210840.1 hypothetical protein -
A6E01_RS17360 990842..991246 + 405 WP_017031481.1 S-adenosylhomocysteine hydrolase -
A6E01_RS17365 991248..992186 + 939 WP_082961401.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
A6E01_RS17370 992597..992829 + 233 Protein_858 hypothetical protein -
A6E01_RS17375 993165..994052 - 888 WP_065210842.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
A6E01_RS17380 994052..994585 - 534 WP_017029554.1 hypothetical protein Antitoxin
A6E01_RS17385 995003..996598 + 1596 WP_065210843.1 site-specific integrase -
A6E01_RS17390 996573..999452 + 2880 WP_065210844.1 site-specific integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(36-258)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 296 a.a.        Molecular weight: 33986.75 Da        Isoelectric Point: 5.6702

>T64300 WP_065210842.1 NZ_CP016178:c994052-993165 [Vibrio breoganii]
MLKEAIKRVVEANPAYAEVTSVIEKEILHHDIMDVLVREGAMQTLTFIGGTSLRLCYNSSRLSEDLDFNGGHDFKPSNFD
GLEQEIQKYIENKYETDVLVSKPVGEPQGNTSSWKISIEKESGRPDLPRQKMHIDVCAIPSFDAKKRPLINHYSIVSPIE
GLIIPVQSLEETFAEKFIALAYRTRRIKPRDVWDLVWIKQQGISVSHDLIAKKLEARDKPNKDFEQQLDAQVEKLLTHEE
VKEDFHMEMSRFVPKTVKERTLDNPDYWLYVQSEIKALSQQVLNRSNSNPFDMSI

Download         Length: 888 bp

>T64300 NZ_CP016178:c994052-993165 [Vibrio breoganii]
ATGTTAAAAGAAGCCATTAAACGTGTAGTTGAAGCAAACCCTGCGTATGCTGAAGTTACATCTGTTATTGAAAAGGAAAT
TCTGCATCATGACATCATGGATGTCTTAGTAAGAGAAGGTGCAATGCAAACGCTGACATTCATTGGAGGAACATCGTTAA
GGCTTTGCTATAACAGCTCTAGATTATCAGAAGACCTAGATTTTAATGGGGGTCATGATTTCAAGCCCTCAAATTTTGAT
GGTCTAGAACAAGAAATCCAGAAGTACATAGAAAATAAGTACGAAACCGATGTCCTTGTAAGTAAGCCTGTTGGTGAACC
TCAAGGAAATACATCGTCATGGAAAATCAGCATTGAGAAGGAGTCAGGTCGGCCAGATTTGCCACGTCAGAAGATGCACA
TTGATGTGTGTGCGATTCCGTCATTCGATGCGAAGAAACGACCGCTTATCAATCACTACAGCATCGTTTCCCCAATAGAA
GGTTTAATAATTCCTGTTCAATCACTAGAGGAGACCTTTGCGGAGAAGTTTATCGCTTTGGCCTATCGTACCAGGCGTAT
AAAACCACGCGATGTTTGGGACTTAGTTTGGATCAAGCAACAGGGAATTAGCGTGTCTCACGATCTGATTGCAAAGAAAT
TGGAGGCACGTGACAAGCCGAATAAGGACTTTGAGCAACAGTTAGATGCTCAAGTAGAAAAGCTCCTCACTCACGAGGAG
GTGAAAGAAGACTTCCATATGGAGATGTCTCGATTTGTACCCAAGACTGTGAAAGAACGTACCCTAGATAATCCTGATTA
TTGGTTGTATGTACAATCTGAGATTAAGGCATTGTCACAACAGGTACTGAACAGGTCCAACTCGAATCCGTTTGATATGA
GTATTTGA

Antitoxin


Download         Length: 178 a.a.        Molecular weight: 19581.81 Da        Isoelectric Point: 10.0802

>AT64300 WP_017029554.1 NZ_CP016178:c994585-994052 [Vibrio breoganii]
MKHLSKKEQLLSAFSASTKAGGGVLTLAEIAFYLNAENNIALRKLLTDCVKKGIVRRLAAGIYESTLTPPDPLTAIYKIA
NKIRGGVLNYISLESQLSYTGVISQIVMGRVTIMTKGRKGTFETPYGVLEFTHTSRPVDKIASNIYLDPEIMMYRASNEQ
AISDLRATKRNLHMLEN

Download         Length: 534 bp

>AT64300 NZ_CP016178:c994585-994052 [Vibrio breoganii]
ATGAAGCATCTATCTAAAAAGGAACAACTGCTATCTGCTTTTTCAGCTTCTACAAAGGCTGGAGGAGGAGTACTAACGCT
TGCAGAAATTGCGTTTTATCTAAACGCCGAAAATAACATTGCCTTGCGCAAGCTCCTTACTGACTGCGTCAAAAAGGGCA
TAGTACGGAGGTTGGCTGCAGGTATATATGAAAGTACACTCACGCCTCCAGATCCTCTTACTGCCATTTATAAGATTGCC
AATAAAATCAGGGGAGGCGTCTTGAATTACATAAGTTTAGAGAGCCAATTAAGCTACACAGGGGTGATTTCTCAAATTGT
TATGGGCAGAGTAACCATAATGACTAAAGGACGTAAAGGTACATTTGAGACCCCTTACGGCGTCCTTGAGTTTACACATA
CCTCACGACCAGTCGATAAGATCGCCAGCAATATCTACCTAGACCCTGAAATTATGATGTATCGAGCGAGTAATGAGCAA
GCAATCTCAGATCTTCGTGCCACCAAACGTAATTTACATATGCTGGAAAACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A193KI30

Antitoxin

Source ID Structure
AlphaFold DB A0A193KI56

References