64299

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) sanaTA/AbiEii-DUF6088
Location 990842..992186 Replicon chromosome
Accession NZ_CP016178
Organism Vibrio breoganii strain FF50

Toxin (Protein)


Gene name sanaT Uniprot ID -
Locus tag A6E01_RS17365 Protein ID WP_082961401.1
Coordinates 991248..992186 (+) Length 313 a.a.

Antitoxin (Protein)


Gene name sanaA Uniprot ID A0A193KHW9
Locus tag A6E01_RS17360 Protein ID WP_017031481.1
Coordinates 990842..991246 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A6E01_RS17335 986032..987123 - 1092 WP_017031470.1 J domain-containing protein -
A6E01_RS17340 988036..988264 + 229 Protein_852 type II toxin-antitoxin system prevent-host-death family antitoxin -
A6E01_RS21055 988447..988662 - 216 WP_198596487.1 transposase -
A6E01_RS21060 988704..989737 + 1034 WP_167714333.1 IS630 family transposase -
A6E01_RS17350 989950..990477 + 528 WP_065210840.1 hypothetical protein -
A6E01_RS17360 990842..991246 + 405 WP_017031481.1 S-adenosylhomocysteine hydrolase Antitoxin
A6E01_RS17365 991248..992186 + 939 WP_082961401.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
A6E01_RS17370 992597..992829 + 233 Protein_858 hypothetical protein -
A6E01_RS17375 993165..994052 - 888 WP_065210842.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
A6E01_RS17380 994052..994585 - 534 WP_017029554.1 hypothetical protein -
A6E01_RS17385 995003..996598 + 1596 WP_065210843.1 site-specific integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(33-300)

Antitoxin

Protein of unknown function DUF6088

(9-129)


Sequences

Toxin        


Download         Length: 313 a.a.        Molecular weight: 36023.68 Da        Isoelectric Point: 6.7516

>T64299 WP_082961401.1 NZ_CP016178:991248-992186 [Vibrio breoganii]
MEKLKQQFLEVSDALELGNPAIIEKDYWVVALLSDLAKVAPNSHKMIFSGGTALAKSNVKIRRMSEDVDIKLIPKPVFDE
LSRSKKKAARKVCINKIEQALTQSERFTVEARSVRDEYRYVELELKYPQQFRQAPCLRPIIKLELIETIPLLDVESRSIQ
SLVAELYKQPQEVKAFDCVSIHATLVEKVISMLRRTMSVKRDTQRKDDVALVRHIYDVHCIVQSEAPDYMALTELFKAVL
KEDIERYGNQHAEFVANPKQELQFGLKELEENPIFRQRFQDFVAPMVFNAEPHDFDTCFASFRGIAESLIQF

Download         Length: 939 bp

>T64299 NZ_CP016178:991248-992186 [Vibrio breoganii]
ATGGAAAAACTAAAGCAACAATTTCTTGAGGTTTCCGATGCACTTGAGCTCGGAAACCCAGCCATTATTGAAAAAGATTA
CTGGGTCGTTGCGCTACTGTCTGATCTCGCTAAAGTGGCACCTAACTCTCATAAAATGATTTTCTCTGGCGGGACTGCTC
TAGCAAAGTCCAACGTTAAAATTCGTAGAATGTCAGAAGACGTAGACATTAAACTGATTCCGAAACCAGTATTTGATGAA
CTAAGTCGCTCCAAAAAGAAAGCGGCTCGTAAGGTATGCATCAACAAGATTGAACAGGCGCTCACTCAGTCAGAGCGATT
CACGGTTGAAGCACGTAGTGTACGTGATGAATACCGTTATGTTGAACTCGAACTTAAGTACCCGCAGCAGTTTCGCCAAG
CACCGTGTCTTCGCCCTATCATTAAACTGGAGCTGATAGAGACAATTCCATTATTGGATGTAGAATCTCGCTCTATTCAG
TCTTTGGTGGCGGAGTTGTATAAACAACCACAAGAGGTGAAGGCGTTTGATTGCGTCTCTATCCATGCAACCTTAGTTGA
AAAAGTGATTTCAATGTTGCGCCGTACCATGTCAGTGAAGCGTGATACACAGCGTAAGGATGATGTGGCTCTCGTACGGC
ACATATACGACGTTCACTGCATAGTTCAATCGGAAGCCCCTGATTATATGGCGCTGACAGAGCTGTTTAAAGCGGTATTA
AAAGAAGATATTGAGCGTTATGGTAACCAACACGCAGAGTTTGTCGCCAATCCCAAGCAAGAGCTACAATTCGGGCTGAA
AGAGCTTGAAGAAAACCCTATTTTTCGCCAACGCTTTCAGGACTTTGTTGCCCCAATGGTATTTAACGCTGAACCCCATG
ATTTTGATACTTGCTTTGCTTCCTTTAGAGGTATAGCTGAATCGCTAATTCAATTTTGA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 15220.45 Da        Isoelectric Point: 10.7023

>AT64299 WP_017031481.1 NZ_CP016178:990842-991246 [Vibrio breoganii]
MTAVDRVYQKIKRSRRYVFERKDFDGFASYDQIGRALRQLVKQGELIKLGYGLYTKARINGLTGRPMPTNPGGSDALIRE
ILRMKGIDFEMDSLSLQSLSGESTQIPSSVQYSWNPKQFNRKLTVGNRVLNSPS

Download         Length: 405 bp

>AT64299 NZ_CP016178:990842-991246 [Vibrio breoganii]
ATGACAGCTGTTGATCGTGTTTATCAAAAGATAAAGCGTTCGAGACGCTATGTTTTTGAGCGCAAAGACTTTGATGGTTT
TGCTAGCTACGATCAAATCGGTCGAGCATTAAGGCAACTGGTTAAACAAGGTGAGTTAATAAAACTTGGTTATGGACTGT
ACACCAAAGCACGCATTAACGGCCTAACCGGAAGACCGATGCCCACGAACCCTGGTGGAAGTGATGCCCTGATACGTGAA
ATATTAAGGATGAAAGGTATCGATTTTGAAATGGACAGCCTATCTTTACAAAGCTTATCAGGAGAAAGTACACAAATCCC
ATCCTCCGTTCAATACTCATGGAACCCCAAACAATTTAATCGCAAATTGACTGTCGGTAACCGAGTATTAAACTCGCCAA
GTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A193KHW9

References