Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 4434126..4434708 Replicon chromosome
Accession NZ_CP016176
Organism Xenorhabdus hominickii strain ANU1

Toxin (Protein)


Gene name PumA Uniprot ID A0A2G0Q0C3
Locus tag A9255_RS20340 Protein ID WP_069318297.1
Coordinates 4434126..4434422 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A2G0Q0D3
Locus tag A9255_RS20345 Protein ID WP_069318298.1
Coordinates 4434424..4434708 (+) Length 95 a.a.

Genomic Context

A9255_RS20315A9255_RS20330A9255_RS20335A9255_RS20340A9255_RS20345A9255_RS20320A9255_RS20325A9255_RS20350A9255_RS23080A9255_RS20360A9255_RS20370A9255_RS20375
Location: 4429541..4432174 (2634 bp)
Type: Others
Protein ID: WP_069318293.1
Location: 4433216..4433545 (330 bp)
Type: Others
Protein ID: WP_069318295.1
Location: 4433685..4434041 (357 bp)
Type: Others
Protein ID: WP_069318296.1
Location: 4434126..4434422 (297 bp)
Type: Toxin
Protein ID: WP_069318297.1
Location: 4434424..4434708 (285 bp)
Type: Antitoxin
Protein ID: WP_069318298.1
Location: 4432202..4432627 (426 bp)
Type: Others
Protein ID: WP_069318594.1
Location: 4432627..4432881 (255 bp)
Type: Others
Protein ID: WP_069318294.1
Location: 4434937..4435416 (480 bp)
Type: Others
Protein ID: WP_069318299.1
Location: 4435538..4435762 (225 bp)
Type: Others
Protein ID: WP_198148792.1
Location: 4436185..4436496 (312 bp)
Type: Others
Protein ID: WP_069318301.1
Location: 4436714..4437094 (381 bp)
Type: Others
Protein ID: WP_069318303.1
Location: 4437339..4437791 (453 bp)
Type: Others
Protein ID: WP_069318304.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
A9255_RS203154429541..4432174+2634WP_069318293.1host specificity protein J-
A9255_RS203204432202..4432627-426WP_069318594.1type II toxin-antitoxin system VapC family toxin-
A9255_RS203254432627..4432881-255WP_069318294.1type II toxin-antitoxin system Phd/YefM family antitoxin-
A9255_RS203304433216..4433545+330WP_069318295.1type I toxin-antitoxin system SymE family toxin-
A9255_RS203354433685..4434041+357WP_069318296.1SymE family type I addiction module toxin-
A9255_RS203404434126..4434422+297WP_069318297.1type II toxin-antitoxin system RelE/ParE family toxinToxin
A9255_RS203454434424..4434708+285WP_069318298.1putative addiction module antidote proteinAntitoxin
A9255_RS203504434937..4435416-480WP_069318299.1hypothetical protein-
A9255_RS230804435538..4435762-225WP_198148792.1hypothetical protein-
A9255_RS203604436185..4436496-312WP_069318301.1hypothetical protein-
A9255_RS203704436714..4437094-381WP_069318303.1hypothetical protein-
A9255_RS203754437339..4437791-453WP_069318304.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideProphage--4341834..4448439106605


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-92)

Antitoxin

Uncharacterized protein HI1420

(3-90)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11216.00 Da        Isoelectric Point: 10.0088

>T64298 WP_069318297.1 NZ_CP016176:4434126-4434422 [Xenorhabdus hominickii]
MITIERTQDFEKWLKSLKDRIAKAKILIRVERMEEGNFGDVEPVGGGVSELRIHYGQGYRVYFANKNNKIILLLCGGDKS
SQQADIKKAKQLAKEWGF

Download         Length: 297 bp

>T64298 NZ_CP016176:4434126-4434422 [Xenorhabdus hominickii]
ATGATAACCATTGAAAGGACTCAAGATTTTGAAAAATGGTTAAAATCCTTAAAAGACAGGATAGCCAAAGCCAAGATCTT
AATCAGAGTTGAAAGAATGGAAGAGGGCAATTTTGGTGATGTTGAACCTGTGGGAGGTGGAGTTTCGGAACTCAGAATAC
ATTACGGGCAAGGCTATCGTGTCTACTTTGCTAATAAAAATAATAAAATCATATTATTGCTCTGTGGTGGAGATAAAAGC
AGCCAGCAGGCAGATATAAAGAAAGCCAAACAACTTGCGAAAGAATGGGGATTTTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10502.96 Da        Isoelectric Point: 7.0117

>AT64298 WP_069318298.1 NZ_CP016176:4434424-4434708 [Xenorhabdus hominickii]
MKTEPKKFDVVEFLETEEDIQAYLNAAIEENDTKYLFKALGNIARIKNISQLSKESGISREGIYKALSGEGNPSFNTVYK
ISKALGLKLHFTGT

Download         Length: 285 bp

>AT64298 NZ_CP016176:4434424-4434708 [Xenorhabdus hominickii]
ATGAAAACAGAACCAAAAAAATTCGATGTTGTGGAGTTTTTAGAAACCGAAGAAGATATTCAGGCATACTTAAATGCCGC
TATCGAAGAGAACGACACAAAATATTTATTTAAAGCGTTAGGCAACATTGCCAGAATAAAAAATATCAGCCAACTTTCTA
AAGAATCAGGAATAAGCCGAGAGGGGATATATAAGGCGTTATCCGGTGAAGGCAACCCGTCGTTTAATACCGTATATAAA
ATATCAAAAGCATTGGGTTTGAAACTGCATTTCACTGGGACTTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A2G0Q0C3

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A2G0Q0D3

References