Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 4434126..4434708 Replicon chromosome
Accession NZ_CP016176
Organism Xenorhabdus hominickii strain ANU1

Toxin (Protein)


Gene name PumA Uniprot ID A0A2G0Q0C3
Locus tag A9255_RS20340 Protein ID WP_069318297.1
Coordinates 4434126..4434422 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A2G0Q0D3
Locus tag A9255_RS20345 Protein ID WP_069318298.1
Coordinates 4434424..4434708 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A9255_RS20315 4429541..4432174 + 2634 WP_069318293.1 host specificity protein J -
A9255_RS20320 4432202..4432627 - 426 WP_069318594.1 type II toxin-antitoxin system VapC family toxin -
A9255_RS20325 4432627..4432881 - 255 WP_069318294.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
A9255_RS20330 4433216..4433545 + 330 WP_069318295.1 type I toxin-antitoxin system SymE family toxin -
A9255_RS20335 4433685..4434041 + 357 WP_069318296.1 SymE family type I addiction module toxin -
A9255_RS20340 4434126..4434422 + 297 WP_069318297.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A9255_RS20345 4434424..4434708 + 285 WP_069318298.1 putative addiction module antidote protein Antitoxin
A9255_RS20350 4434937..4435416 - 480 WP_069318299.1 hypothetical protein -
A9255_RS23080 4435538..4435762 - 225 WP_198148792.1 hypothetical protein -
A9255_RS20360 4436185..4436496 - 312 WP_069318301.1 hypothetical protein -
A9255_RS20370 4436714..4437094 - 381 WP_069318303.1 hypothetical protein -
A9255_RS20375 4437339..4437791 - 453 WP_069318304.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4341834..4448439 106605


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-92)

Antitoxin

Uncharacterized protein HI1420

(3-90)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11216.00 Da        Isoelectric Point: 10.0088

>T64298 WP_069318297.1 NZ_CP016176:4434126-4434422 [Xenorhabdus hominickii]
MITIERTQDFEKWLKSLKDRIAKAKILIRVERMEEGNFGDVEPVGGGVSELRIHYGQGYRVYFANKNNKIILLLCGGDKS
SQQADIKKAKQLAKEWGF

Download         Length: 297 bp

>T64298 NZ_CP016176:4434126-4434422 [Xenorhabdus hominickii]
ATGATAACCATTGAAAGGACTCAAGATTTTGAAAAATGGTTAAAATCCTTAAAAGACAGGATAGCCAAAGCCAAGATCTT
AATCAGAGTTGAAAGAATGGAAGAGGGCAATTTTGGTGATGTTGAACCTGTGGGAGGTGGAGTTTCGGAACTCAGAATAC
ATTACGGGCAAGGCTATCGTGTCTACTTTGCTAATAAAAATAATAAAATCATATTATTGCTCTGTGGTGGAGATAAAAGC
AGCCAGCAGGCAGATATAAAGAAAGCCAAACAACTTGCGAAAGAATGGGGATTTTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10502.96 Da        Isoelectric Point: 7.0117

>AT64298 WP_069318298.1 NZ_CP016176:4434424-4434708 [Xenorhabdus hominickii]
MKTEPKKFDVVEFLETEEDIQAYLNAAIEENDTKYLFKALGNIARIKNISQLSKESGISREGIYKALSGEGNPSFNTVYK
ISKALGLKLHFTGT

Download         Length: 285 bp

>AT64298 NZ_CP016176:4434424-4434708 [Xenorhabdus hominickii]
ATGAAAACAGAACCAAAAAAATTCGATGTTGTGGAGTTTTTAGAAACCGAAGAAGATATTCAGGCATACTTAAATGCCGC
TATCGAAGAGAACGACACAAAATATTTATTTAAAGCGTTAGGCAACATTGCCAGAATAAAAAATATCAGCCAACTTTCTA
AAGAATCAGGAATAAGCCGAGAGGGGATATATAAGGCGTTATCCGGTGAAGGCAACCCGTCGTTTAATACCGTATATAAA
ATATCAAAAGCATTGGGTTTGAAACTGCATTTCACTGGGACTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G0Q0C3

Antitoxin

Source ID Structure
AlphaFold DB A0A2G0Q0D3

References