Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 3887259..3887903 Replicon chromosome
Accession NZ_CP016176
Organism Xenorhabdus hominickii strain ANU1

Toxin (Protein)


Gene name hicA Uniprot ID A0A068R5W8
Locus tag A9255_RS17790 Protein ID WP_045959536.1
Coordinates 3887259..3887432 (+) Length 58 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A2G0QGB3
Locus tag A9255_RS17795 Protein ID WP_069317884.1
Coordinates 3887487..3887903 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A9255_RS22765 3884127..3884285 + 159 WP_157104628.1 hypothetical protein -
A9255_RS17775 3884269..3884994 + 726 WP_069317881.1 hypothetical protein -
A9255_RS17780 3884966..3885505 + 540 WP_069317882.1 hypothetical protein -
A9255_RS17785 3885502..3887139 + 1638 WP_069317883.1 hypothetical protein -
A9255_RS17790 3887259..3887432 + 174 WP_045959536.1 type II toxin-antitoxin system HicA family toxin Toxin
A9255_RS17795 3887487..3887903 + 417 WP_069317884.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
A9255_RS17805 3888954..3889748 + 795 WP_069317885.1 GNAT family N-acetyltransferase -
A9255_RS17810 3889804..3891651 - 1848 WP_069317886.1 RNA polymerase sigma factor RpoD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3858472..3893724 35252


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-65)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6652.78 Da        Isoelectric Point: 11.1572

>T64297 WP_045959536.1 NZ_CP016176:3887259-3887432 [Xenorhabdus hominickii]
VKQSEFRRWLEAQGVEVSNGTNHLKLKYQGKRSIMPRHPSQELKEPLRKAIIKQLGL

Download         Length: 174 bp

>T64297 NZ_CP016176:3887259-3887432 [Xenorhabdus hominickii]
GTGAAGCAAAGCGAGTTTAGACGGTGGCTGGAAGCTCAAGGCGTTGAAGTTTCAAATGGGACAAACCATCTGAAACTGAA
ATATCAGGGGAAACGAAGCATCATGCCGAGGCACCCCAGCCAAGAGCTTAAAGAACCACTGAGGAAAGCAATCATTAAGC
AATTAGGATTGTGA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15304.36 Da        Isoelectric Point: 4.2778

>AT64297 WP_069317884.1 NZ_CP016176:3887487-3887903 [Xenorhabdus hominickii]
MRYPVTLEPVEEGGYFVSFPDIPEALTQGETREEALEMALDALITSFEFYFEDNEKIPSPSPVGQGDDYVDVPLSVASKV
LMLNAFVDSRLTQTELAQRMGVKKQEVTRLFDLHHSTKIDTVAKAATAIGHQLTVSIL

Download         Length: 417 bp

>AT64297 NZ_CP016176:3887487-3887903 [Xenorhabdus hominickii]
ATGCGATATCCAGTCACACTAGAGCCAGTAGAAGAGGGCGGTTATTTTGTCTCGTTCCCGGATATCCCCGAAGCCTTAAC
GCAAGGGGAGACACGGGAAGAAGCGCTGGAGATGGCCCTTGATGCGCTAATAACGTCCTTTGAATTTTATTTTGAAGACA
ATGAGAAAATCCCATCACCAAGCCCTGTGGGGCAAGGTGATGATTATGTCGATGTGCCCTTAAGCGTGGCCTCAAAGGTG
CTGATGCTTAATGCGTTTGTTGATTCCCGATTAACGCAAACTGAGCTTGCCCAGCGTATGGGGGTGAAAAAGCAGGAAGT
CACCCGCCTCTTTGACTTACACCATTCGACCAAGATTGATACGGTAGCTAAGGCAGCAACAGCAATCGGGCATCAATTAA
CTGTGTCCATCCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A068R5W8

Antitoxin

Source ID Structure
AlphaFold DB A0A2G0QGB3

References