Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2447103..2447722 Replicon chromosome
Accession NZ_CP016176
Organism Xenorhabdus hominickii strain ANU1

Toxin (Protein)


Gene name Hha Uniprot ID W1IZI5
Locus tag A9255_RS11420 Protein ID WP_038238384.1
Coordinates 2447519..2447722 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A2G0Q8S0
Locus tag A9255_RS11415 Protein ID WP_069316817.1
Coordinates 2447103..2447471 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A9255_RS11405 2442118..2443317 + 1200 WP_069316815.1 efflux RND transporter periplasmic adaptor subunit -
A9255_RS11410 2443332..2446481 + 3150 WP_069316816.1 efflux RND transporter permease subunit -
A9255_RS11415 2447103..2447471 + 369 WP_069316817.1 Hha toxicity modulator TomB Antitoxin
A9255_RS11420 2447519..2447722 + 204 WP_038238384.1 hemolysin expression modulator Hha Toxin
A9255_RS11430 2448716..2449996 - 1281 WP_069316818.1 ammonium transporter AmtB -
A9255_RS11435 2450013..2450351 - 339 WP_069316819.1 P-II family nitrogen regulator -
A9255_RS11440 2450511..2452289 - 1779 WP_069316820.1 SmdB family multidrug efflux ABC transporter permease/ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8089.39 Da        Isoelectric Point: 6.9770

>T64296 WP_038238384.1 NZ_CP016176:2447519-2447722 [Xenorhabdus hominickii]
MTKIDYLMRLRKCTSIETLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 204 bp

>T64296 NZ_CP016176:2447519-2447722 [Xenorhabdus hominickii]
ATGACTAAAATTGACTATCTGATGCGTTTGAGAAAATGCACTTCTATTGAAACACTAGAACGTGTAATTGAAAAAAATAA
ATACGAGCTTTCGGATGATGAACTTGAATTGTTCTACTCTGCTGCTGACCACCGTTTAGCTGAACTTACCATGAACAAAC
TCTATGATAAAATCCCATCATCTGTTTGGAAGTTTGTCCGCTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14449.21 Da        Isoelectric Point: 5.1659

>AT64296 WP_069316817.1 NZ_CP016176:2447103-2447471 [Xenorhabdus hominickii]
MDEYSPKRHDIAELKYLCENLIHEALSVLNRTDNHWAHDLTSENSLKLNELIEHIAAFVWSFKIKYSDNHYLSTLIDEYL
DETYNLFGSDKISFLELTRWQRTNEHLTNILLHDLNVALSKT

Download         Length: 369 bp

>AT64296 NZ_CP016176:2447103-2447471 [Xenorhabdus hominickii]
ATGGATGAATATTCACCAAAAAGACATGATATTGCTGAATTAAAATATTTATGTGAAAACTTAATTCACGAGGCATTATC
AGTTCTGAACCGTACTGATAATCATTGGGCTCACGATCTGACTTCCGAGAACAGCTTAAAATTAAACGAATTGATCGAGC
ACATTGCAGCTTTTGTCTGGAGCTTTAAAATTAAATACTCAGATAACCACTATCTCAGTACCTTAATTGATGAGTATCTG
GATGAAACATATAATTTGTTCGGAAGTGATAAGATAAGCTTTCTTGAACTTACAAGATGGCAGAGAACAAACGAACACTT
AACTAACATTCTGTTACATGATTTGAATGTTGCTTTAAGCAAAACCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A068QYL0

Antitoxin

Source ID Structure
AlphaFold DB A0A2G0Q8S0

References