Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1411462..1411945 Replicon chromosome
Accession NZ_CP016175
Organism Streptococcus suis strain LSM102

Toxin (Protein)


Gene name relE Uniprot ID D5AIX4
Locus tag A9494_RS07110 Protein ID WP_012027435.1
Coordinates 1411462..1411722 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0Z8BIX7
Locus tag A9494_RS07115 Protein ID WP_012775256.1
Coordinates 1411724..1411945 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A9494_RS07085 1406847..1408076 - 1230 WP_012775253.1 tetratricopeptide repeat protein -
A9494_RS07090 1408066..1409232 - 1167 WP_012775254.1 AI-2E family transporter -
A9494_RS07095 1409368..1410372 + 1005 WP_012028380.1 lactonase family protein -
A9494_RS07100 1410436..1410621 + 186 WP_002935693.1 hypothetical protein -
A9494_RS07105 1410654..1411295 - 642 WP_012775255.1 HAD family hydrolase -
A9494_RS07110 1411462..1411722 - 261 WP_012027435.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A9494_RS07115 1411724..1411945 - 222 WP_012775256.1 hypothetical protein Antitoxin
A9494_RS07120 1412255..1413562 - 1308 WP_002935704.1 phosphopyruvate hydratase -
A9494_RS07125 1413712..1414164 + 453 WP_012028381.1 DUF1694 domain-containing protein -
A9494_RS07130 1414171..1414400 - 230 Protein_1316 hypothetical protein -
A9494_RS07135 1414391..1415518 - 1128 WP_012028382.1 glycerate kinase -
A9494_RS07140 1415626..1416276 + 651 WP_012027441.1 HAD family hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1416713..1417915 1202


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10273.79 Da        Isoelectric Point: 9.3944

>T64291 WP_012027435.1 NZ_CP016175:c1411722-1411462 [Streptococcus suis]
MYHLEYSKKAQKQIMKLDRQIQRLLFAWIDKHLEGTDNPRANGKGLTGNHANEWRYRIGDYRLICDIQDDKLVILALEFG
HRKDVY

Download         Length: 261 bp

>T64291 NZ_CP016175:c1411722-1411462 [Streptococcus suis]
ATGTATCATTTAGAGTATTCTAAAAAGGCTCAAAAGCAAATTATGAAATTAGATAGGCAAATTCAGAGGCTGTTGTTTGC
TTGGATTGATAAACACTTAGAAGGGACTGATAATCCACGCGCCAATGGTAAAGGTTTGACAGGCAATCATGCTAACGAGT
GGCGTTATCGTATCGGAGATTACCGACTGATTTGCGATATTCAAGATGATAAGTTGGTTATTTTAGCACTTGAGTTTGGA
CATCGTAAAGATGTCTATTGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8566.55 Da        Isoelectric Point: 4.4791

>AT64291 WP_012775256.1 NZ_CP016175:c1411945-1411724 [Streptococcus suis]
MSTVTIRLNQEEEVFFKSYAQLTGQSLSSLFKKALERDIEDEYDLKIYHQAYDEYKADPETISHADFKKELGL

Download         Length: 222 bp

>AT64291 NZ_CP016175:c1411945-1411724 [Streptococcus suis]
ATGAGTACAGTGACAATCAGATTAAATCAAGAAGAAGAAGTATTCTTTAAAAGCTATGCACAATTAACAGGTCAAAGTCT
TTCTAGCCTTTTTAAGAAAGCTTTGGAGCGTGATATTGAAGATGAGTATGATTTAAAAATCTATCATCAAGCTTATGATG
AGTACAAAGCAGATCCAGAAACAATTAGTCATGCTGATTTTAAGAAAGAGCTAGGATTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K1T1M7

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z8BIX7

References