Detailed information of TA system TA064289

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): omega-epsilon-zeta/zeta-couple_hipB
• Location: 894873..896125
• Replicon: chromosome
• Accession: NZ_CP016175
• Organism: Streptococcus suis strain LSM102

Toxin (Protein)

• Gene name: sezT
• Uniprot ID: A0A0Z9JWN4
• Locus tag: A9494_RS04550
• Protein ID: WP_011922437.1
• Coordinates: 894873..895649 (-)
• Length: 259 a.a.

Antitoxin (Protein)

• Gene name: sezA
• Uniprot ID: -
• Locus tag: A9494_RS04555
• Protein ID: WP_012775115.1
• Coordinates: 895649..896125 (-)
• Length: 159 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A9494_RS04520	890103..890489	-	387	WP_000985015.1	YdcP family protein	-
A9494_RS04525	890505..890819	-	315	WP_000420682.1	YdcP family protein	-
A9494_RS04540	891441..892802	-	1362	Protein_818	ATP-dependent helicase	-
A9494_RS04545	892789..894876	-	2088	WP_011922436.1	AAA family ATPase	-
A9494_RS04550	894873..895649	-	777	WP_011922437.1	zeta toxin family protein	Toxin
A9494_RS04555	895649..896125	-	477	WP_012775115.1	helix-turn-helix domain-containing protein	Antitoxin
A9494_RS04560	896195..896485	-	291	WP_024379089.1	hypothetical protein	-
A9494_RS04565	896535..896924	-	390	WP_011922440.1	methyl-accepting chemotaxis protein	-
A9494_RS04570	896921..897148	-	228	WP_011922441.1	hypothetical protein	-
A9494_RS04575	897202..898278	-	1077	WP_011922442.1	toprim domain-containing protein	-
A9494_RS04580	898317..898955	-	639	WP_011922443.1	hypothetical protein	-
A9494_RS04585	900356..900955	-	600	WP_011922444.1	response regulator transcription factor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	tet(M)	-	809731..901931	92200

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (28-214)

Antitoxin

• Cro/C1-type helix-turn-helix domain (3-60)

Sequences

Toxin

Protein

• Length: 259 a.a.
• Molecular weight: 29171.98 Da
• Isoelectric Point: 5.2489

>T64289 WP_011922437.1 NZ_CP016175:c895649-894873 [Streptococcus suis]
MRLEEFSEAAFQKALQRTIRALIRGKTIPEQPKAILLGGQSGAGKTTIHRIKQKEFQGNIIIIDGDSYRSQHPNYLALQE
KYGKDSVDYTKGFAGKMVEHLVDELSTQGYHLLIEGTLRTTQVPRQTAQLLASKGYQVSLAVIGTKPELSYLSTLIRYEE
LYAIDPNQARATPKEHHDGIVENLVDNLSELEREQLFDQIQIYQRDRTCIYDSEIDEGSAVEVLQECLFGQWSKVEEEML
KAGQERLGELVSANGEKK

Nucleotide

• Length: 777 bp

>T64289 NZ_CP016175:c895649-894873 [Streptococcus suis]
ATGAGGTTGGAAGAATTTAGTGAGGCTGCATTTCAGAAGGCCTTACAGCGAACCATTCGGGCTTTAATCCGAGGCAAAAC
AATTCCAGAACAACCGAAAGCTATCTTACTTGGAGGACAAAGCGGAGCCGGTAAGACAACGATTCATCGGATTAAGCAAA
AGGAATTTCAAGGCAATATCATTATCATCGATGGTGACAGCTACCGTTCTCAACATCCCAATTACTTAGCACTGCAAGAA
AAGTATGGCAAGGACAGCGTGGACTATACCAAGGGATTTGCAGGAAAAATGGTAGAACATCTGGTTGATGAACTTAGTAC
ACAAGGTTATCATTTGTTAATTGAAGGGACTTTGCGTACCACTCAAGTTCCTCGTCAGACTGCTCAATTATTAGCTTCGA
AAGGATACCAAGTTTCCTTAGCTGTGATTGGTACCAAACCAGAATTGTCCTATCTCAGCACCTTGATTCGTTACGAAGAA
CTTTATGCTATCGATCCTAATCAGGCTAGAGCAACACCAAAAGAACACCATGATGGGATTGTTGAGAACTTGGTTGATAA
CCTAAGCGAGTTAGAAAGAGAGCAACTCTTTGACCAAATTCAAATTTATCAAAGAGATAGAACTTGTATCTATGATTCTG
AAATTGATGAGGGATCCGCGGTAGAAGTGCTACAAGAATGCCTCTTTGGGCAATGGAGTAAAGTCGAGGAAGAGATGTTG
AAGGCCGGACAGGAACGGTTGGGGGAATTAGTCTCAGCTAATGGAGAGAAGAAATGA

Antitoxin

Protein

• Length: 159 a.a.
• Molecular weight: 18282.69 Da
• Isoelectric Point: 4.4750

>AT64289 WP_012775115.1 NZ_CP016175:c896125-895649 [Streptococcus suis]
MIGDNIKSLRRTHDLTQPEFAKMVGISRNSLSRYENGTSTVSTELIDRICQKFNVSYVDIVGEDKMLTPVEDYHLTLKVE
VIKERGAAILSQLYRYQDSQDIAFDDESNPWILMSDDLAELINTKIYLVDTFDEIERYNGYLDGIERMLDMVHHRVVA

Nucleotide

• Length: 477 bp

>AT64289 NZ_CP016175:c896125-895649 [Streptococcus suis]
ATGATCGGAGACAATATAAAATCACTACGCCGAACACACGATTTAACACAGCCAGAATTTGCGAAAATGGTCGGGATTTC
ACGCAATAGTCTGAGTCGCTACGAAAATGGAACCAGCACTGTTTCAACTGAACTCATCGACCGTATTTGTCAGAAATTTA
ACGTTTCTTATGTCGATATTGTAGGAGAGGACAAGATGTTAACTCCTGTCGAAGATTACCATCTGACTTTAAAAGTAGAA
GTGATAAAAGAACGTGGAGCAGCCATTTTATCACAGCTTTATCGATATCAAGATAGTCAGGATATTGCTTTTGATGATGA
ATCCAACCCTTGGATTCTCATGAGTGATGATTTGGCTGAATTGATCAATACGAAAATTTACCTTGTCGATACTTTCGATG
AAATTGAGCGTTACAATGGCTATTTAGACGGTATCGAGCGGATGTTGGACATGGTGCATCATCGGGTGGTGGCTTAA

Structures

Toxin

• AlphaFold DB: A0A0Z9JWN4