Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relBE/RelE(toxin) |
Location | 848034..848526 | Replicon | chromosome |
Accession | NZ_CP016175 | ||
Organism | Streptococcus suis strain LSM102 |
Toxin (Protein)
Gene name | relE | Uniprot ID | D5AHJ6 |
Locus tag | A9494_RS04280 | Protein ID | WP_011922404.1 |
Coordinates | 848034..848291 (-) | Length | 86 a.a. |
Antitoxin (Protein)
Gene name | relB | Uniprot ID | D5AHJ7 |
Locus tag | A9494_RS04285 | Protein ID | WP_012775104.1 |
Coordinates | 848275..848526 (-) | Length | 84 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
A9494_RS04260 | 843668..844738 | + | 1071 | WP_012775101.1 | tyrosine recombinase XerS | - |
A9494_RS04265 | 844808..846316 | - | 1509 | WP_011922400.1 | phosphomannomutase/phosphoglucomutase | - |
A9494_RS04270 | 846392..847333 | - | 942 | WP_012775102.1 | sensor histidine kinase | - |
A9494_RS04275 | 847330..847995 | - | 666 | WP_012775103.1 | response regulator transcription factor | - |
A9494_RS04280 | 848034..848291 | - | 258 | WP_011922404.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
A9494_RS04285 | 848275..848526 | - | 252 | WP_012775104.1 | hypothetical protein | Antitoxin |
A9494_RS04290 | 848618..850588 | - | 1971 | WP_012775105.1 | FtsX-like permease family protein | - |
A9494_RS04295 | 850589..851341 | - | 753 | WP_011922409.1 | ABC transporter ATP-binding protein | - |
A9494_RS04300 | 851477..852211 | - | 735 | WP_011922410.1 | ABC transporter permease | - |
A9494_RS04305 | 852213..852959 | - | 747 | WP_011922411.1 | ABC transporter permease | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Integrative and Conjugative Element | tet(M) | - | 809731..901931 | 92200 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 86 a.a. Molecular weight: 9981.62 Da Isoelectric Point: 10.8924
>T64288 WP_011922404.1 NZ_CP016175:c848291-848034 [Streptococcus suis]
MKTCYKLVPTSRFIKQLKKLDKFTQKQITNYLSSHVTDNPRQYGKALTANRSGQWRYRIGNYRVIVNIEDDKLIVTSIKM
RNGSI
MKTCYKLVPTSRFIKQLKKLDKFTQKQITNYLSSHVTDNPRQYGKALTANRSGQWRYRIGNYRVIVNIEDDKLIVTSIKM
RNGSI
Download Length: 258 bp
>T64288 NZ_CP016175:c848291-848034 [Streptococcus suis]
ATGAAGACCTGTTATAAACTCGTACCGACCAGTCGTTTTATTAAACAGTTGAAAAAGTTGGACAAATTTACCCAAAAACA
GATTACCAACTACTTGTCCAGTCATGTGACTGACAACCCTAGACAATACGGAAAAGCCTTGACTGCTAATCGTTCTGGCC
AATGGCGCTATCGTATCGGCAATTACAGGGTTATCGTTAATATTGAAGATGATAAATTGATTGTGACAAGCATAAAAATG
AGAAATGGAAGTATATAA
ATGAAGACCTGTTATAAACTCGTACCGACCAGTCGTTTTATTAAACAGTTGAAAAAGTTGGACAAATTTACCCAAAAACA
GATTACCAACTACTTGTCCAGTCATGTGACTGACAACCCTAGACAATACGGAAAAGCCTTGACTGCTAATCGTTCTGGCC
AATGGCGCTATCGTATCGGCAATTACAGGGTTATCGTTAATATTGAAGATGATAAATTGATTGTGACAAGCATAAAAATG
AGAAATGGAAGTATATAA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9325.59 Da Isoelectric Point: 3.7666
>AT64288 WP_012775104.1 NZ_CP016175:c848526-848275 [Streptococcus suis]
MAAITLKVSEQDKLFMQAMAKFEGVSLSELIRTKTLEALEDEYDARVADIALSEYEADLAKGIEPISWEEMLEELGLTDE
DLL
MAAITLKVSEQDKLFMQAMAKFEGVSLSELIRTKTLEALEDEYDARVADIALSEYEADLAKGIEPISWEEMLEELGLTDE
DLL
Download Length: 252 bp
>AT64288 NZ_CP016175:c848526-848275 [Streptococcus suis]
ATGGCAGCTATTACATTGAAAGTTTCTGAGCAGGACAAGCTCTTTATGCAGGCTATGGCAAAGTTTGAAGGTGTCAGTTT
GTCAGAACTCATTCGGACTAAAACCCTTGAAGCTCTCGAAGATGAATATGATGCCCGTGTGGCAGATATCGCTCTGTCTG
AATACGAGGCAGACTTGGCGAAAGGCATTGAGCCGATTAGCTGGGAGGAAATGTTGGAAGAGTTGGGGTTGACGGATGAA
GACCTGTTATAA
ATGGCAGCTATTACATTGAAAGTTTCTGAGCAGGACAAGCTCTTTATGCAGGCTATGGCAAAGTTTGAAGGTGTCAGTTT
GTCAGAACTCATTCGGACTAAAACCCTTGAAGCTCTCGAAGATGAATATGATGCCCGTGTGGCAGATATCGCTCTGTCTG
AATACGAGGCAGACTTGGCGAAAGGCATTGAGCCGATTAGCTGGGAGGAAATGTTGGAAGAGTTGGGGTTGACGGATGAA
GACCTGTTATAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0Z8U747 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0Z9GU89 |