Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 56983..57521 Replicon plasmid unnamed1
Accession NZ_CP016173
Organism Bordetella flabilis strain AU10664

Toxin (Protein)


Gene name relE Uniprot ID A0A193GLU3
Locus tag BAU07_RS26310 Protein ID WP_066665859.1
Coordinates 56983..57276 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A193GNF7
Locus tag BAU07_RS26315 Protein ID WP_066665967.1
Coordinates 57309..57521 (-) Length 71 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BAU07_RS26290 52108..54594 + 2487 WP_066665854.1 inverse autotransporter beta domain-containing protein -
BAU07_RS26295 54769..55542 - 774 WP_066665856.1 hypothetical protein -
BAU07_RS26300 55623..56210 - 588 WP_066665965.1 hypothetical protein -
BAU07_RS26305 56222..56731 - 510 WP_066665858.1 hypothetical protein -
BAU07_RS26310 56983..57276 - 294 WP_066665859.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BAU07_RS26315 57309..57521 - 213 WP_066665967.1 hypothetical protein Antitoxin
BAU07_RS26320 57620..58750 - 1131 WP_084026130.1 tyrosine-type recombinase/integrase -
BAU07_RS27310 58747..58950 - 204 WP_157122574.1 hypothetical protein -
BAU07_RS26325 58980..59837 - 858 WP_157122575.1 hypothetical protein -
BAU07_RS26330 60170..60475 + 306 WP_066665868.1 hypothetical protein -
BAU07_RS27315 60501..60722 + 222 WP_157122576.1 hypothetical protein -
BAU07_RS26335 60765..60995 + 231 WP_066665871.1 hypothetical protein -
BAU07_RS26340 61001..61366 + 366 WP_066665873.1 hypothetical protein -
BAU07_RS26345 61371..61718 + 348 WP_084026131.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..118591 118591


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-88)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11132.79 Da        Isoelectric Point: 6.2097

>T64286 WP_066665859.1 NZ_CP016173:c57276-56983 [Bordetella flabilis]
MLPIFWSAPALDDLDRITDHIAEFDVYAAITIHELIESAVHPVADHPYIFKRGRVPGTREIVAHPNYIVIYRVQADYVEV
LSVLHARQEYPPRTLAK

Download         Length: 294 bp

>T64286 NZ_CP016173:c57276-56983 [Bordetella flabilis]
ATGCTTCCCATCTTCTGGAGTGCGCCCGCGCTCGATGATTTGGATCGCATCACGGACCACATCGCAGAGTTCGATGTGTA
TGCCGCCATCACCATCCATGAGCTGATTGAAAGCGCCGTGCATCCCGTTGCGGACCACCCGTACATCTTCAAACGCGGCC
GGGTGCCGGGCACGCGGGAGATCGTGGCGCACCCCAACTACATCGTCATCTATCGCGTCCAGGCCGATTACGTCGAAGTC
CTATCGGTGCTGCACGCCCGACAAGAGTACCCTCCCCGGACCTTGGCGAAGTAG

Antitoxin


Download         Length: 71 a.a.        Molecular weight: 7712.60 Da        Isoelectric Point: 4.4455

>AT64286 WP_066665967.1 NZ_CP016173:c57521-57309 [Bordetella flabilis]
MSTALSPIVSEFETQEQADSYDRWFRAKVQASLDDPRPSIPHDEAMALIRQKLAAKLADAESNPIAPSQA

Download         Length: 213 bp

>AT64286 NZ_CP016173:c57521-57309 [Bordetella flabilis]
ATGAGCACTGCCCTCTCCCCGATAGTCTCTGAGTTCGAGACGCAAGAACAAGCGGATAGCTATGACCGCTGGTTCCGTGC
GAAGGTGCAAGCCAGTCTTGACGACCCTCGGCCCAGCATCCCGCACGACGAGGCTATGGCGCTGATTCGTCAAAAACTTG
CCGCGAAGCTGGCAGATGCGGAAAGCAATCCCATAGCGCCTTCGCAGGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A193GLU3

Antitoxin

Source ID Structure
AlphaFold DB A0A193GNF7

References