64285

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 4537767..4538404 Replicon chromosome
Accession NZ_CP016172
Organism Bordetella flabilis strain AU10664

Toxin (Protein)


Gene name vapC Uniprot ID A0A193GH30
Locus tag BAU07_RS20180 Protein ID WP_066661579.1
Coordinates 4538003..4538404 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A193GIM9
Locus tag BAU07_RS20175 Protein ID WP_066661572.1
Coordinates 4537767..4538003 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BAU07_RS20155 4533765..4534373 - 609 WP_066661560.1 recombination mediator RecR -
BAU07_RS20160 4534453..4534779 - 327 WP_066661563.1 YbaB/EbfC family nucleoid-associated protein -
BAU07_RS20165 4534837..4537320 - 2484 WP_066661570.1 DNA polymerase III subunit gamma/tau -
BAU07_RS20175 4537767..4538003 + 237 WP_066661572.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
BAU07_RS20180 4538003..4538404 + 402 WP_066661579.1 type II toxin-antitoxin system VapC family toxin Toxin
BAU07_RS20190 4539424..4540239 + 816 WP_084026095.1 D-alanyl-D-alanine endopeptidase -
BAU07_RS20195 4540422..4541063 - 642 WP_066661584.1 HD domain-containing protein -
BAU07_RS20200 4541186..4542151 + 966 WP_066661587.1 GlxA family transcriptional regulator -
BAU07_RS20205 4542389..4542880 - 492 WP_066661589.1 Cys-tRNA(Pro) deacylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-120)

Antitoxin

SpoVT-AbrB domain

(7-45)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14949.28 Da        Isoelectric Point: 7.3198

>T64285 WP_066661579.1 NZ_CP016172:4538003-4538404 [Bordetella flabilis]
MPRYMLDTNMCIYLMKNQPEQVARRFAACYVGDVVMSAITFAELNYGVAASANPARERDNLEVLTSLIIVAPFDLNAAHA
YGPVRMATRERKKDHLDKLIASHAIALQAVLVTNNERDFVAYPGLRIENWLHA

Download         Length: 402 bp

>T64285 NZ_CP016172:4538003-4538404 [Bordetella flabilis]
ATGCCGCGCTACATGCTCGACACGAATATGTGCATCTACCTGATGAAGAATCAGCCCGAGCAGGTCGCGCGTCGTTTCGC
TGCCTGCTACGTCGGGGATGTCGTCATGTCGGCAATCACATTCGCGGAGCTGAATTATGGTGTGGCCGCTTCGGCCAACC
CCGCGCGGGAGCGGGATAACCTCGAAGTCCTGACATCGCTTATCATCGTGGCCCCCTTCGATCTCAACGCCGCTCACGCC
TACGGACCGGTCCGCATGGCCACGCGGGAGCGAAAAAAAGACCACCTGGACAAGCTGATCGCTTCACATGCCATTGCGTT
GCAGGCGGTGCTGGTGACCAATAACGAGCGTGACTTCGTCGCCTATCCCGGCCTCCGGATCGAGAACTGGCTGCATGCCT
GA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8993.06 Da        Isoelectric Point: 4.5112

>AT64285 WP_066661572.1 NZ_CP016172:4537767-4538003 [Bordetella flabilis]
MQLTKVFRNGNSQAVRIPAELAYDRTDLELEIERVGDELRIRPANRSLAGVLDLFARFSPDFMREGRGDQEQAEREDI

Download         Length: 237 bp

>AT64285 NZ_CP016172:4537767-4538003 [Bordetella flabilis]
ATGCAACTTACCAAGGTTTTCAGGAACGGCAACTCCCAGGCAGTCCGCATCCCGGCGGAACTCGCGTACGACCGGACGGA
TCTCGAGCTTGAAATCGAACGCGTAGGCGATGAGCTCCGCATCCGACCAGCCAACCGCTCGCTCGCCGGTGTTCTGGACC
TGTTCGCGCGGTTCTCGCCCGACTTCATGAGGGAAGGAAGAGGTGATCAGGAACAGGCGGAGAGGGAGGACATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A193GH30

Antitoxin

Source ID Structure
AlphaFold DB A0A193GIM9

References