64284

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 4262147..4262804 Replicon chromosome
Accession NZ_CP016172
Organism Bordetella flabilis strain AU10664

Toxin (Protein)


Gene name hicA Uniprot ID A0A193GGF1
Locus tag BAU07_RS18805 Protein ID WP_066660815.1
Coordinates 4262147..4262326 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A261RG31
Locus tag BAU07_RS18810 Protein ID WP_066660835.1
Coordinates 4262388..4262804 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BAU07_RS18775 4258007..4258402 - 396 WP_066665551.1 type II toxin-antitoxin system VapC family toxin -
BAU07_RS18780 4258399..4258635 - 237 WP_066660803.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
BAU07_RS18785 4259506..4260192 + 687 WP_066660806.1 SOS response-associated peptidase family protein -
BAU07_RS18795 4260906..4261085 + 180 WP_066665552.1 DUF3606 domain-containing protein -
BAU07_RS18800 4261089..4262078 + 990 WP_066660812.1 non-homologous end-joining DNA ligase -
BAU07_RS18805 4262147..4262326 + 180 WP_066660815.1 type II toxin-antitoxin system HicA family toxin Toxin
BAU07_RS18810 4262388..4262804 + 417 WP_066660835.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
BAU07_RS18815 4262805..4263596 - 792 WP_066660837.1 DNA adenine methylase -
BAU07_RS27200 4263742..4264260 - 519 WP_157122320.1 hypothetical protein -
BAU07_RS18825 4264744..4265205 - 462 WP_157122322.1 hypothetical protein -
BAU07_RS18830 4265220..4265750 - 531 WP_066660843.1 glycoside hydrolase family 19 protein -
BAU07_RS18835 4266001..4266417 - 417 WP_066660845.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4258007..4301780 43773


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-62)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6768.79 Da        Isoelectric Point: 11.2257

>T64284 WP_066660815.1 NZ_CP016172:4262147-4262326 [Bordetella flabilis]
VKQSEFRRWLADQGATFKEGKGHTKVYFQGKQTTLPRHGSQEIGEGLRRTILKQLGLKK

Download         Length: 180 bp

>T64284 NZ_CP016172:4262147-4262326 [Bordetella flabilis]
GTGAAGCAGAGCGAGTTCAGACGGTGGCTCGCGGACCAGGGAGCGACTTTCAAAGAAGGCAAAGGCCACACGAAAGTCTA
CTTCCAGGGCAAGCAAACCACCCTGCCTCGGCACGGTAGCCAGGAGATCGGCGAAGGGCTGAGGCGAACGATCCTGAAGC
AGCTTGGATTGAAGAAGTAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15157.45 Da        Isoelectric Point: 4.6743

>AT64284 WP_066660835.1 NZ_CP016172:4262388-4262804 [Bordetella flabilis]
MLRYPAKIEPDTVGYLVTFRDIPEANSAGETVEEAREMAADALLVAMDFYFEDRRPVPPPSKARDGEVLVALPASVSAKV
LLLNEMLAQHVTPAELARRMGTRPQEVNRIVNLEHATKIDTIAQALATMGKELELSVS

Download         Length: 417 bp

>AT64284 NZ_CP016172:4262388-4262804 [Bordetella flabilis]
ATGTTGCGTTATCCAGCCAAGATTGAACCGGACACGGTTGGCTACCTCGTTACGTTCCGGGATATACCGGAAGCCAATTC
AGCGGGCGAGACGGTGGAAGAAGCACGCGAAATGGCCGCGGATGCGTTGCTGGTAGCCATGGACTTCTATTTCGAGGACC
GCCGCCCCGTACCTCCGCCATCCAAGGCTCGGGACGGTGAGGTGCTGGTGGCGCTACCGGCCAGCGTTTCGGCCAAGGTG
CTGTTGCTCAACGAAATGCTGGCCCAGCACGTCACGCCGGCCGAACTCGCGCGCCGCATGGGCACCCGCCCCCAAGAAGT
GAACCGCATCGTAAACCTGGAGCACGCCACCAAGATCGACACGATTGCGCAAGCGCTGGCCACAATGGGCAAAGAGCTTG
AACTATCGGTATCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A193GGF1

Antitoxin

Source ID Structure
AlphaFold DB A0A261RG31

References