Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 5808189..5809782 Replicon chromosome
Accession NZ_CP016171
Organism Bordetella bronchialis strain AU17976

Toxin (Protein)


Gene name hipA Uniprot ID A0A193G4C9
Locus tag BAU08_RS25730 Protein ID WP_066672336.1
Coordinates 5808442..5809782 (+) Length 447 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A193G380
Locus tag BAU08_RS25725 Protein ID WP_066672334.1
Coordinates 5808189..5808440 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BAU08_RS25700 5803833..5804165 - 333 WP_066672324.1 (2Fe-2S)-binding protein -
BAU08_RS25705 5804162..5804956 - 795 WP_066672326.1 ABC transporter permease -
BAU08_RS25710 5804960..5805856 - 897 WP_066672328.1 ABC transporter permease -
BAU08_RS25715 5805938..5807002 - 1065 WP_066672330.1 ABC transporter ATP-binding protein -
BAU08_RS25720 5807202..5808047 + 846 WP_066672332.1 IclR family transcriptional regulator -
BAU08_RS25725 5808189..5808440 + 252 WP_066672334.1 helix-turn-helix domain-containing protein Antitoxin
BAU08_RS25730 5808442..5809782 + 1341 WP_066672336.1 type II toxin-antitoxin system HipA family toxin Toxin
BAU08_RS25735 5809832..5810701 - 870 WP_066672340.1 LysR family transcriptional regulator -
BAU08_RS25740 5810845..5811840 + 996 WP_066672344.1 tripartite tricarboxylate transporter substrate binding protein -
BAU08_RS25745 5811837..5813237 + 1401 WP_066672346.1 MmgE/PrpD family protein -
BAU08_RS25750 5813490..5814464 + 975 WP_066672348.1 tripartite tricarboxylate transporter substrate binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(8-108)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-67)


Sequences

Toxin        


Download         Length: 447 a.a.        Molecular weight: 48607.54 Da        Isoelectric Point: 7.0003

>T64283 WP_066672336.1 NZ_CP016171:5808442-5809782 [Bordetella bronchialis]
MARRLHRLAIWMNGTHVGLWAEEAGVSSFQYSPAWLDDPAGRPLSLSLPFRLGNAPYKGAVVHDFFDNLLPDSDAIRRRL
AQHHRADSAAPFDLLAVLGRDCVGAVQLLPPGEVPTGLDHIEADPLNDADIARILKAAVSGAPLGHEDRTADLRLSIAGA
QEKTALLRHQGQWLRPRGSTPTTHILKLPMGLVGAMQADMHASVENEWLCSKLAAAYGLPVAHCDMARFEDQKALVVERF
DRRFTDTGTIVRLPQEDMCQAMGVSPLRKYQADGGPGITAIIRGVLDSSEREEDVRAFYKAQMFFWMLAATDGHAKNFSI
ALLAGGRYHATPLYDILSAHPIIGNKRAQLAPQRAKLAMGVRGSGGLHYRLAEIRRRHWYTQAAEAGLDKSMVDDIIGEL
VEATEPAIEHAAALLPPGFPAHVADAVFAGLRAQRDKLVSQANDPA

Download         Length: 1341 bp

>T64283 NZ_CP016171:5808442-5809782 [Bordetella bronchialis]
ATGGCCCGAAGGCTGCACCGCCTGGCCATCTGGATGAACGGCACGCACGTCGGCCTTTGGGCGGAGGAGGCCGGCGTGTC
GTCGTTCCAATACAGCCCGGCATGGCTGGACGATCCGGCGGGGCGCCCGCTTTCGCTGTCCCTTCCCTTCCGCCTGGGCA
ACGCGCCCTACAAGGGAGCGGTCGTCCACGATTTCTTCGACAATCTTCTGCCCGACAGCGACGCGATCCGGCGCAGGCTG
GCCCAACACCACCGCGCCGACAGCGCAGCCCCCTTCGACCTCTTGGCGGTACTGGGCCGCGACTGCGTGGGCGCCGTGCA
ATTGCTGCCGCCCGGCGAAGTCCCGACCGGCCTGGACCATATCGAAGCCGACCCGCTAAACGATGCGGATATCGCGCGGA
TCCTGAAAGCCGCGGTCAGCGGCGCACCGCTGGGCCACGAGGACCGGACCGCCGATCTGCGCCTGTCCATCGCGGGCGCC
CAGGAAAAAACGGCCCTGCTGCGCCACCAGGGGCAGTGGCTGCGCCCGCGCGGCAGCACGCCCACCACCCATATCCTGAA
ATTGCCGATGGGACTGGTCGGCGCGATGCAGGCGGACATGCATGCCTCCGTGGAAAACGAATGGTTGTGCTCCAAGCTGG
CGGCGGCCTACGGGCTGCCGGTGGCCCATTGCGACATGGCTCGTTTCGAGGACCAGAAGGCCCTGGTGGTGGAGCGCTTC
GACCGCCGTTTCACGGATACCGGCACCATCGTGCGCCTGCCCCAGGAAGACATGTGCCAGGCCATGGGCGTGTCGCCGTT
GCGCAAATACCAGGCGGACGGCGGCCCGGGCATAACGGCCATCATCCGCGGCGTGCTGGATTCATCCGAACGCGAAGAAG
ACGTGCGCGCCTTCTACAAGGCACAGATGTTCTTCTGGATGCTGGCCGCCACCGATGGGCACGCCAAGAACTTCAGCATC
GCGCTGTTGGCCGGCGGCCGCTACCATGCGACGCCGCTATACGACATTCTTTCCGCGCACCCCATCATCGGCAACAAGCG
CGCGCAATTGGCGCCGCAGCGCGCCAAGCTGGCCATGGGGGTGCGGGGATCCGGCGGGCTGCATTACCGGCTGGCGGAAA
TCCGCCGGCGGCACTGGTACACGCAGGCGGCCGAGGCGGGGCTGGACAAAAGCATGGTCGACGACATCATCGGCGAATTG
GTGGAGGCCACCGAGCCCGCCATCGAACACGCCGCGGCCCTGCTGCCGCCAGGTTTCCCGGCGCATGTCGCGGATGCCGT
CTTCGCCGGCCTGCGCGCGCAGCGCGACAAGCTGGTCAGCCAGGCGAACGACCCGGCCTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9528.13 Da        Isoelectric Point: 11.1412

>AT64283 WP_066672334.1 NZ_CP016171:5808189-5808440 [Bordetella bronchialis]
MDYPVRTLQQLRPILQGFRKAKGLTQAQLAARLGITQQSYAKLEAAPEKASFDRVFRILQMLRVELALRPMDQADRAVAR
SEW

Download         Length: 252 bp

>AT64283 NZ_CP016171:5808189-5808440 [Bordetella bronchialis]
ATGGACTATCCCGTCCGCACCCTCCAACAGCTACGACCCATCCTGCAAGGGTTCCGCAAGGCCAAAGGGCTGACCCAGGC
GCAACTGGCGGCCCGCCTCGGCATCACCCAGCAAAGCTATGCCAAGCTGGAAGCCGCCCCGGAAAAGGCCAGCTTCGACC
GGGTCTTCCGCATCCTGCAGATGCTGCGTGTCGAGCTTGCCCTGCGGCCCATGGACCAGGCGGATCGCGCCGTCGCCAGG
TCGGAGTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A193G4C9

Antitoxin

Source ID Structure
AlphaFold DB A0A193G380

References