Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 5808189..5809782 Replicon chromosome
Accession NZ_CP016171
Organism Bordetella bronchialis strain AU17976

Toxin (Protein)


Gene name hipA Uniprot ID A0A193G4C9
Locus tag BAU08_RS25730 Protein ID WP_066672336.1
Coordinates 5808442..5809782 (+) Length 447 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A193G380
Locus tag BAU08_RS25725 Protein ID WP_066672334.1
Coordinates 5808189..5808440 (+) Length 84 a.a.

Genomic Context


BAU08_RS25720BAU08_RS25725BAU08_RS25730BAU08_RS25740BAU08_RS25745BAU08_RS25750BAU08_RS25700BAU08_RS25705BAU08_RS25710BAU08_RS25715BAU08_RS25735
Location: 5807202..5808047 (846 bp)
Type: Others
Protein ID: WP_066672332.1
Location: 5808189..5808440 (252 bp)
Type: Antitoxin
Protein ID: WP_066672334.1
Location: 5808442..5809782 (1341 bp)
Type: Toxin
Protein ID: WP_066672336.1
Location: 5810845..5811840 (996 bp)
Type: Others
Protein ID: WP_066672344.1
Location: 5811837..5813237 (1401 bp)
Type: Others
Protein ID: WP_066672346.1
Location: 5813490..5814464 (975 bp)
Type: Others
Protein ID: WP_066672348.1
Location: 5803833..5804165 (333 bp)
Type: Others
Protein ID: WP_066672324.1
Location: 5804162..5804956 (795 bp)
Type: Others
Protein ID: WP_066672326.1
Location: 5804960..5805856 (897 bp)
Type: Others
Protein ID: WP_066672328.1
Location: 5805938..5807002 (1065 bp)
Type: Others
Protein ID: WP_066672330.1
Location: 5809832..5810701 (870 bp)
Type: Others
Protein ID: WP_066672340.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
BAU08_RS257005803833..5804165-333WP_066672324.1(2Fe-2S)-binding protein-
BAU08_RS257055804162..5804956-795WP_066672326.1ABC transporter permease-
BAU08_RS257105804960..5805856-897WP_066672328.1ABC transporter permease-
BAU08_RS257155805938..5807002-1065WP_066672330.1ABC transporter ATP-binding protein-
BAU08_RS257205807202..5808047+846WP_066672332.1IclR family transcriptional regulator-
BAU08_RS257255808189..5808440+252WP_066672334.1helix-turn-helix domain-containing proteinAntitoxin
BAU08_RS257305808442..5809782+1341WP_066672336.1type II toxin-antitoxin system HipA family toxinToxin
BAU08_RS257355809832..5810701-870WP_066672340.1LysR family transcriptional regulator-
BAU08_RS257405810845..5811840+996WP_066672344.1tripartite tricarboxylate transporter substrate binding protein-
BAU08_RS257455811837..5813237+1401WP_066672346.1MmgE/PrpD family protein-
BAU08_RS257505813490..5814464+975WP_066672348.1tripartite tricarboxylate transporter substrate binding protein-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(8-108)

Antitoxin

(14-67)


Sequences


Toxin        


Download         Length: 447 a.a.        Molecular weight: 48607.54 Da        Isoelectric Point: 7.0003

>T64283 WP_066672336.1 NZ_CP016171:5808442-5809782 [Bordetella bronchialis]
MARRLHRLAIWMNGTHVGLWAEEAGVSSFQYSPAWLDDPAGRPLSLSLPFRLGNAPYKGAVVHDFFDNLLPDSDAIRRRL
AQHHRADSAAPFDLLAVLGRDCVGAVQLLPPGEVPTGLDHIEADPLNDADIARILKAAVSGAPLGHEDRTADLRLSIAGA
QEKTALLRHQGQWLRPRGSTPTTHILKLPMGLVGAMQADMHASVENEWLCSKLAAAYGLPVAHCDMARFEDQKALVVERF
DRRFTDTGTIVRLPQEDMCQAMGVSPLRKYQADGGPGITAIIRGVLDSSEREEDVRAFYKAQMFFWMLAATDGHAKNFSI
ALLAGGRYHATPLYDILSAHPIIGNKRAQLAPQRAKLAMGVRGSGGLHYRLAEIRRRHWYTQAAEAGLDKSMVDDIIGEL
VEATEPAIEHAAALLPPGFPAHVADAVFAGLRAQRDKLVSQANDPA

Download         Length: 1341 bp

>T64283 NZ_CP016171:5808442-5809782 [Bordetella bronchialis]
ATGGCCCGAAGGCTGCACCGCCTGGCCATCTGGATGAACGGCACGCACGTCGGCCTTTGGGCGGAGGAGGCCGGCGTGTC
GTCGTTCCAATACAGCCCGGCATGGCTGGACGATCCGGCGGGGCGCCCGCTTTCGCTGTCCCTTCCCTTCCGCCTGGGCA
ACGCGCCCTACAAGGGAGCGGTCGTCCACGATTTCTTCGACAATCTTCTGCCCGACAGCGACGCGATCCGGCGCAGGCTG
GCCCAACACCACCGCGCCGACAGCGCAGCCCCCTTCGACCTCTTGGCGGTACTGGGCCGCGACTGCGTGGGCGCCGTGCA
ATTGCTGCCGCCCGGCGAAGTCCCGACCGGCCTGGACCATATCGAAGCCGACCCGCTAAACGATGCGGATATCGCGCGGA
TCCTGAAAGCCGCGGTCAGCGGCGCACCGCTGGGCCACGAGGACCGGACCGCCGATCTGCGCCTGTCCATCGCGGGCGCC
CAGGAAAAAACGGCCCTGCTGCGCCACCAGGGGCAGTGGCTGCGCCCGCGCGGCAGCACGCCCACCACCCATATCCTGAA
ATTGCCGATGGGACTGGTCGGCGCGATGCAGGCGGACATGCATGCCTCCGTGGAAAACGAATGGTTGTGCTCCAAGCTGG
CGGCGGCCTACGGGCTGCCGGTGGCCCATTGCGACATGGCTCGTTTCGAGGACCAGAAGGCCCTGGTGGTGGAGCGCTTC
GACCGCCGTTTCACGGATACCGGCACCATCGTGCGCCTGCCCCAGGAAGACATGTGCCAGGCCATGGGCGTGTCGCCGTT
GCGCAAATACCAGGCGGACGGCGGCCCGGGCATAACGGCCATCATCCGCGGCGTGCTGGATTCATCCGAACGCGAAGAAG
ACGTGCGCGCCTTCTACAAGGCACAGATGTTCTTCTGGATGCTGGCCGCCACCGATGGGCACGCCAAGAACTTCAGCATC
GCGCTGTTGGCCGGCGGCCGCTACCATGCGACGCCGCTATACGACATTCTTTCCGCGCACCCCATCATCGGCAACAAGCG
CGCGCAATTGGCGCCGCAGCGCGCCAAGCTGGCCATGGGGGTGCGGGGATCCGGCGGGCTGCATTACCGGCTGGCGGAAA
TCCGCCGGCGGCACTGGTACACGCAGGCGGCCGAGGCGGGGCTGGACAAAAGCATGGTCGACGACATCATCGGCGAATTG
GTGGAGGCCACCGAGCCCGCCATCGAACACGCCGCGGCCCTGCTGCCGCCAGGTTTCCCGGCGCATGTCGCGGATGCCGT
CTTCGCCGGCCTGCGCGCGCAGCGCGACAAGCTGGTCAGCCAGGCGAACGACCCGGCCTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9528.13 Da        Isoelectric Point: 11.1412

>AT64283 WP_066672334.1 NZ_CP016171:5808189-5808440 [Bordetella bronchialis]
MDYPVRTLQQLRPILQGFRKAKGLTQAQLAARLGITQQSYAKLEAAPEKASFDRVFRILQMLRVELALRPMDQADRAVAR
SEW

Download         Length: 252 bp

>AT64283 NZ_CP016171:5808189-5808440 [Bordetella bronchialis]
ATGGACTATCCCGTCCGCACCCTCCAACAGCTACGACCCATCCTGCAAGGGTTCCGCAAGGCCAAAGGGCTGACCCAGGC
GCAACTGGCGGCCCGCCTCGGCATCACCCAGCAAAGCTATGCCAAGCTGGAAGCCGCCCCGGAAAAGGCCAGCTTCGACC
GGGTCTTCCGCATCCTGCAGATGCTGCGTGTCGAGCTTGCCCTGCGGCCCATGGACCAGGCGGATCGCGCCGTCGCCAGG
TCGGAGTGGTGA

Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
AlphaFold DBA0A193G4C9


Antitoxin

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Source
ID
Structure
AlphaFold DBA0A193G380

References