Detailed information of TA system TA064282

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/upstrm_HI1419-dnstrm_HI1420
• Location: 5392558..5393169
• Replicon: chromosome
• Accession: NZ_CP016171
• Organism: Bordetella bronchialis strain AU17976

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: BAU08_RS27015
• Protein ID: WP_082988432.1
• Coordinates: 5392870..5393169 (-)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A193G433
• Locus tag: BAU08_RS23815
• Protein ID: WP_066356218.1
• Coordinates: 5392558..5392866 (-)
• Length: 103 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BAU08_RS23785	5387602..5388561	-	960	WP_066356205.1	tripartite tricarboxylate transporter substrate binding protein	-
BAU08_RS23790	5388698..5389606	+	909	WP_197513454.1	transcriptional regulator GcvA	-
BAU08_RS23795	5389890..5390822	-	933	WP_156774185.1	tripartite tricarboxylate transporter substrate binding protein	-
BAU08_RS23810	5392305..5392484	+	180	WP_066356213.1	hypothetical protein	-
BAU08_RS23815	5392558..5392866	-	309	WP_066356218.1	putative addiction module antidote protein	Antitoxin
BAU08_RS27015	5392870..5393169	-	300	WP_082988432.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BAU08_RS23825	5393346..5393906	+	561	WP_066356224.1	YdeI/OmpD-associated family protein	-
BAU08_RS23835	5394460..5395374	+	915	WP_066356226.1	c-type cytochrome	-
BAU08_RS23840	5395706..5396926	-	1221	WP_156774122.1	hypothetical protein	-
BAU08_RS23845	5397034..5397495	+	462	WP_066356231.1	helix-turn-helix domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (13-95)

Antitoxin

• Cro/C1-type helix-turn-helix domain (49-93)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11102.90 Da
• Isoelectric Point: 10.5793

>T64282 WP_082988432.1 NZ_CP016171:c5393169-5392870 [Bordetella bronchialis]
MAYIVKLLPGFSDWLKGLKDPVTRQRLVKRLDKARLGNLGEVKPVGNGVSEMREDFGPGWRMYYVQRGNTVVVMLAGGNK
RSQQADIRRAIALAESLED

Nucleotide

• Length: 300 bp

>T64282 NZ_CP016171:c5393169-5392870 [Bordetella bronchialis]
ATGGCCTACATCGTAAAACTTCTCCCCGGATTCTCCGACTGGCTCAAAGGTCTCAAGGATCCCGTAACCCGGCAACGCTT
GGTCAAGCGCCTTGATAAGGCTCGATTGGGAAACCTGGGAGAGGTGAAGCCTGTAGGGAATGGCGTCTCTGAAATGCGAG
AAGACTTCGGCCCCGGGTGGCGCATGTATTACGTTCAGCGCGGCAATACCGTAGTAGTGATGCTGGCCGGTGGGAACAAG
CGAAGCCAACAAGCCGATATTCGACGCGCAATCGCGCTTGCCGAGTCTTTGGAGGACTGA

Antitoxin

Protein

• Length: 103 a.a.
• Molecular weight: 10969.55 Da
• Isoelectric Point: 4.8358

>AT64282 WP_066356218.1 NZ_CP016171:c5392866-5392558 [Bordetella bronchialis]
MTKNKISELPEFDAAEFLNSEEDIAAYLTTVLEDDDPALLAVALGNIARARGMTQVAKDAGIAREALYKALRPGSDPRFE
TISRVCAALGVRLVAQPKSLAH

Nucleotide

• Length: 309 bp

>AT64282 NZ_CP016171:c5392866-5392558 [Bordetella bronchialis]
ATGACCAAAAATAAGATTTCCGAGCTTCCTGAATTCGACGCCGCTGAATTCTTGAATAGCGAAGAAGACATAGCCGCGTA
CCTGACAACCGTGCTGGAAGATGACGATCCAGCGCTTCTTGCGGTCGCTCTCGGTAACATTGCGCGCGCCCGGGGGATGA
CTCAGGTGGCGAAAGACGCCGGTATCGCGCGGGAAGCTTTGTACAAGGCGCTGCGTCCTGGTAGCGATCCGCGGTTTGAA
ACGATTAGCCGCGTATGCGCGGCGTTGGGAGTGCGCCTGGTGGCGCAACCGAAAAGCCTGGCACACTGA

Structures

Antitoxin

• AlphaFold DB: A0A193G433