Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-MazE
Location 2991409..2991956 Replicon chromosome
Accession NZ_CP016171
Organism Bordetella bronchialis strain AU17976

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag BAU08_RS13420 Protein ID WP_197509530.1
Coordinates 2991409..2991735 (-) Length 109 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag BAU08_RS13425 Protein ID WP_066349781.1
Coordinates 2991732..2991956 (-) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BAU08_RS13400 2987293..2988657 + 1365 WP_066669714.1 allantoinase AllB -
BAU08_RS13405 2988650..2989999 + 1350 WP_066669716.1 MmgE/PrpD family protein -
BAU08_RS13410 2990268..2991197 + 930 WP_066349778.1 LysR family transcriptional regulator -
BAU08_RS13420 2991409..2991735 - 327 WP_197509530.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
BAU08_RS13425 2991732..2991956 - 225 WP_066349781.1 antitoxin MazE family protein Antitoxin
BAU08_RS13430 2992068..2993276 - 1209 WP_066669718.1 MFS transporter -
BAU08_RS13435 2993276..2993992 - 717 WP_066669720.1 arsenical resistance protein ArsH -
BAU08_RS13440 2994144..2994638 - 495 WP_066349784.1 arsenate reductase ArsC -
BAU08_RS26785 2994740..2995066 - 327 WP_082988199.1 metalloregulator ArsR/SmtB family transcription factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-105)

Antitoxin

Antitoxin MazE-like

(8-72)


Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 11749.91 Da        Isoelectric Point: 10.1863

>T64280 WP_197509530.1 NZ_CP016171:c2991735-2991409 [Bordetella bronchialis]
MMRGDLVTVAVQGDFGKLRPALVIQSDLLSEHGSVTVLPVTSSLVEAPLLRVMAKPSLQNRLRQPSQIMVDKAVTVRRDK
LGAAFGRIEPETLVEVERCLAVFLGIAK

Download         Length: 327 bp

>T64280 NZ_CP016171:c2991735-2991409 [Bordetella bronchialis]
CTGATGCGAGGTGATCTGGTAACCGTCGCTGTCCAAGGGGATTTTGGAAAGCTTCGTCCCGCGTTGGTGATCCAGTCGGA
CCTGCTCAGCGAACATGGCAGTGTGACGGTCCTTCCGGTAACCAGCAGTCTGGTCGAAGCGCCGCTGCTGCGAGTAATGG
CGAAACCTAGCCTGCAGAACCGCCTGCGGCAACCTTCCCAAATTATGGTGGACAAAGCCGTCACCGTAAGGCGTGACAAG
CTCGGCGCGGCTTTCGGTCGTATCGAGCCGGAAACCCTCGTCGAGGTCGAACGGTGCCTGGCGGTCTTTCTTGGAATCGC
CAAGTAG

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8465.46 Da        Isoelectric Point: 6.9791

>AT64280 WP_066349781.1 NZ_CP016171:c2991956-2991732 [Bordetella bronchialis]
MPGSNVNARVNKHRAALRMAGLRPVQIWVPDTRRPNFAEECRRQSVLASRDDSRDDDMQRLMDQAVSEVDGWDA

Download         Length: 225 bp

>AT64280 NZ_CP016171:c2991956-2991732 [Bordetella bronchialis]
ATGCCGGGAAGCAACGTTAACGCCCGTGTGAATAAGCACCGTGCGGCTTTGCGCATGGCAGGGCTGCGGCCGGTGCAAAT
CTGGGTACCCGATACGCGCCGGCCGAATTTCGCCGAGGAATGCCGTCGCCAATCCGTCTTGGCAAGCCGTGACGATTCAA
GGGACGACGATATGCAGCGGCTGATGGACCAGGCCGTGTCCGAGGTAGACGGCTGGGATGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References