Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-MazE
Location 1310941..1311571 Replicon chromosome
Accession NZ_CP016171
Organism Bordetella bronchialis strain AU17976

Toxin (Protein)


Gene name vapC Uniprot ID A0A193FT64
Locus tag BAU08_RS05975 Protein ID WP_066668562.1
Coordinates 1310941..1311351 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A193FUD0
Locus tag BAU08_RS05980 Protein ID WP_066668564.1
Coordinates 1311338..1311571 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BAU08_RS05960 1307229..1308305 + 1077 WP_066668556.1 alpha/beta hydrolase -
BAU08_RS05965 1308283..1309653 - 1371 WP_082988516.1 MFS transporter -
BAU08_RS05970 1309947..1310744 - 798 WP_197509514.1 DUF899 domain-containing protein -
BAU08_RS05975 1310941..1311351 - 411 WP_066668562.1 PIN domain-containing protein Toxin
BAU08_RS05980 1311338..1311571 - 234 WP_066668564.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
BAU08_RS05985 1311695..1312360 + 666 WP_066668565.1 alpha-ketoglutarate-dependent dioxygenase AlkB -
BAU08_RS05990 1312357..1315716 - 3360 WP_066668566.1 autotransporter domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(8-118)

Antitoxin

SpoVT-AbrB domain

(5-35)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15115.43 Da        Isoelectric Point: 5.5971

>T64278 WP_066668562.1 NZ_CP016171:c1311351-1310941 [Bordetella bronchialis]
MSVSRNKVFIDSNVVLYLLSGDAAKADKSEELLKQRPTISVQVLNEVTSVCVRKLRMAWREVDDFLAVVKNLCNIVPVTI
ETHDLARLLAHRHGLGFYDACIVAAARLEGCDTLYTEDMHDGLAIDADLALRNPYA

Download         Length: 411 bp

>T64278 NZ_CP016171:c1311351-1310941 [Bordetella bronchialis]
ATGAGCGTGAGTAGGAACAAAGTCTTCATCGACAGCAATGTCGTGCTCTACCTGCTGTCCGGGGACGCCGCCAAGGCCGA
CAAGTCCGAAGAACTGCTGAAGCAGCGGCCAACCATCAGCGTGCAGGTACTGAACGAAGTGACCAGTGTCTGTGTGCGTA
AATTGCGCATGGCGTGGCGGGAAGTCGATGACTTCCTCGCGGTGGTAAAGAACCTGTGCAATATCGTCCCCGTGACCATA
GAAACCCACGACCTTGCGCGGCTTCTTGCCCACCGCCACGGCCTGGGCTTCTATGATGCATGCATCGTGGCGGCCGCCCG
GCTGGAAGGGTGCGACACGCTTTACACCGAAGACATGCATGACGGCCTGGCCATAGACGCGGACCTTGCGTTACGCAACC
CCTACGCGTGA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8789.04 Da        Isoelectric Point: 8.9128

>AT64278 WP_066668564.1 NZ_CP016171:c1311571-1311338 [Bordetella bronchialis]
MQVAKWGNSLAVRLPASLVEALELHEGDDIEIVIDTPRTFAVRKKPGADALLSRLRRFRGRLPADFTFRRDEANERE

Download         Length: 234 bp

>AT64278 NZ_CP016171:c1311571-1311338 [Bordetella bronchialis]
ATGCAAGTAGCCAAATGGGGCAACAGCCTGGCGGTACGCCTTCCCGCCAGCCTGGTAGAGGCGCTGGAACTGCACGAAGG
CGATGACATCGAAATCGTGATCGACACACCGCGCACTTTCGCCGTGCGCAAGAAACCGGGCGCCGACGCGTTGTTGTCCC
GGCTGCGCAGGTTCCGCGGCAGACTCCCCGCCGACTTCACGTTCCGGCGGGACGAAGCGAATGAGCGTGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A193FT64

Antitoxin

Source ID Structure
AlphaFold DB A0A193FUD0

References