Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 5720365..5721958 Replicon chromosome
Accession NZ_CP016170
Organism Bordetella bronchialis strain AU3182

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag BAU06_RS25150 Protein ID WP_066357162.1
Coordinates 5720618..5721958 (+) Length 447 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag BAU06_RS25145 Protein ID WP_066357156.1
Coordinates 5720365..5720616 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BAU06_RS25120 5716007..5716339 - 333 WP_066357143.1 (2Fe-2S)-binding protein -
BAU06_RS25125 5716336..5717130 - 795 WP_066357146.1 ABC transporter permease -
BAU06_RS25130 5717134..5718030 - 897 WP_082993818.1 ABC transporter permease -
BAU06_RS25135 5718112..5719176 - 1065 WP_066357148.1 ABC transporter ATP-binding protein -
BAU06_RS25140 5719376..5720221 + 846 WP_066357150.1 IclR family transcriptional regulator -
BAU06_RS25145 5720365..5720616 + 252 WP_066357156.1 helix-turn-helix domain-containing protein Antitoxin
BAU06_RS25150 5720618..5721958 + 1341 WP_066357162.1 type II toxin-antitoxin system HipA family toxin Toxin
BAU06_RS25155 5722009..5722878 - 870 WP_066357167.1 LysR family transcriptional regulator -
BAU06_RS25160 5723022..5724017 + 996 WP_066357171.1 tripartite tricarboxylate transporter substrate binding protein -
BAU06_RS25165 5724014..5725414 + 1401 WP_066357174.1 MmgE/PrpD family protein -
BAU06_RS25170 5725667..5726641 + 975 WP_066357186.1 tripartite tricarboxylate transporter substrate binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(155-405)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-67)


Sequences

Toxin        


Download         Length: 447 a.a.        Molecular weight: 48544.48 Da        Isoelectric Point: 6.8875

>T64277 WP_066357162.1 NZ_CP016170:5720618-5721958 [Bordetella bronchialis]
MARRLHRLAIWMNGAHVGLWAEEAGVSSLQYSPAWLDDPAGRPLSLSLPFRLGNAPYKGAVVHDFFDNLLPDSDAIRRRL
AQHHRADSAAPFDLLAVLGRDCVGAVQLLPPGEVPTGLDHIEADPLDDADIARILKAAVSGAPLGHEDRTADLRLSIAGA
QEKTALLRHQGQWLRPRGSTPTTHILKLPMGLVGAMQADMHASVENEWLCSKLAAAYGLPVAHCDMARFEDQKALVVERF
DRRFTDTGTIVRLPQEDMCQAMGVSPLRKYQADGGPGITAIIRGVLDSSEREEDVRAFYKAQMFFWMLAATDGHAKNFSI
ALLAGGRYHATPLYDILSAHPIIGNKRAQLAPQRAKLAMGVRGSGGLHYRLAEIRRRHWYTQAAEAGLDKSMVDDIIGEL
VEATEPAIEHAAALLPPGFPAHVADAVFAGLRAQRDKLVSQANDPA

Download         Length: 1341 bp

>T64277 NZ_CP016170:5720618-5721958 [Bordetella bronchialis]
ATGGCCCGAAGGCTGCACCGGCTGGCCATCTGGATGAACGGCGCGCACGTCGGCCTTTGGGCGGAGGAGGCCGGCGTGTC
GTCGCTCCAATACAGCCCGGCATGGCTGGACGATCCCGCGGGGCGCCCGCTTTCGCTGTCCCTTCCCTTCCGCCTGGGCA
ACGCGCCCTACAAGGGAGCGGTCGTCCACGATTTCTTCGACAATCTTCTGCCCGACAGCGACGCGATCCGGCGCAGGCTG
GCCCAACACCACCGCGCCGACAGCGCAGCCCCTTTCGACCTCTTGGCGGTACTGGGCCGCGACTGCGTGGGCGCCGTGCA
ATTGCTGCCGCCCGGCGAAGTCCCGACCGGCCTGGACCATATCGAAGCGGACCCGCTGGACGATGCGGATATCGCGCGGA
TCCTGAAAGCCGCGGTCAGCGGCGCACCGCTGGGCCACGAGGACCGGACCGCAGATCTGCGCCTGTCCATCGCGGGCGCC
CAGGAAAAAACGGCCCTGCTGCGCCACCAGGGGCAGTGGCTGCGCCCGCGTGGCAGCACGCCCACCACCCATATCCTGAA
ATTGCCGATGGGACTGGTCGGCGCGATGCAGGCGGACATGCATGCCTCCGTGGAAAACGAATGGTTGTGCTCCAAGCTGG
CGGCGGCCTACGGGCTGCCGGTGGCCCATTGCGACATGGCTCGTTTCGAGGACCAGAAGGCCCTGGTGGTGGAGCGCTTC
GACCGCCGTTTCACGGATACCGGCACCATCGTGCGCCTGCCCCAGGAAGACATGTGCCAGGCCATGGGCGTGTCGCCGTT
GCGCAAATACCAGGCGGACGGCGGCCCGGGCATAACGGCCATCATCCGCGGCGTGCTGGATTCATCCGAACGCGAAGAAG
ACGTGCGCGCCTTCTACAAGGCACAGATGTTCTTCTGGATGCTGGCCGCCACCGATGGGCACGCCAAGAACTTCAGCATC
GCGCTGTTGGCCGGCGGCCGCTACCATGCGACGCCGCTATACGACATTCTTTCCGCGCACCCCATCATCGGCAACAAGCG
CGCGCAATTGGCGCCGCAGCGCGCCAAGCTGGCCATGGGGGTGCGGGGATCCGGCGGGCTGCATTACCGGCTGGCGGAAA
TCCGCCGGCGGCACTGGTACACGCAGGCGGCAGAGGCGGGGCTGGACAAAAGCATGGTCGACGACATCATCGGCGAATTG
GTCGAGGCCACCGAGCCCGCCATCGAACACGCCGCGGCCCTGCTGCCGCCAGGTTTCCCGGCGCATGTCGCGGATGCCGT
CTTCGCCGGCCTGCGCGCGCAGCGCGACAAGCTGGTCAGCCAGGCGAACGACCCGGCCTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9500.12 Da        Isoelectric Point: 10.9692

>AT64277 WP_066357156.1 NZ_CP016170:5720365-5720616 [Bordetella bronchialis]
MDYPVRTLQQLRPILQGFRKAKGLTQAQLAARLGITQQSYAKLEAAPEKASFDRVFRILQMLRVELALRPMDQADRAVAK
SEW

Download         Length: 252 bp

>AT64277 NZ_CP016170:5720365-5720616 [Bordetella bronchialis]
ATGGACTATCCCGTCCGCACGCTCCAACAGCTGCGACCCATCCTGCAAGGGTTCCGCAAGGCCAAAGGGCTGACCCAGGC
GCAACTGGCGGCCCGCCTGGGCATCACCCAGCAAAGCTATGCCAAGCTGGAAGCCGCCCCGGAAAAGGCCAGCTTCGACC
GGGTTTTCCGCATCCTGCAGATGCTGCGTGTCGAGCTTGCCCTGCGGCCCATGGACCAGGCGGATCGCGCCGTCGCCAAG
TCGGAGTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References