Detailed information of TA system TA064276

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/upstrm_HI1419-dnstrm_HI1420
• Location: 5308149..5308760
• Replicon: chromosome
• Accession: NZ_CP016170
• Organism: Bordetella bronchialis strain AU3182

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: BAU06_RS26380
• Protein ID: WP_082988432.1
• Coordinates: 5308461..5308760 (-)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A193G433
• Locus tag: BAU06_RS23260
• Protein ID: WP_066356218.1
• Coordinates: 5308149..5308457 (-)
• Length: 103 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BAU06_RS23235	5303295..5304254	-	960	WP_066356205.1	tripartite tricarboxylate transporter substrate binding protein	-
BAU06_RS23240	5304391..5305299	+	909	WP_197509369.1	transcriptional regulator GcvA	-
BAU06_RS23245	5305481..5306470	-	990	WP_066356208.1	tripartite tricarboxylate transporter substrate binding protein	-
BAU06_RS23255	5307896..5308075	+	180	WP_066356213.1	hypothetical protein	-
BAU06_RS23260	5308149..5308457	-	309	WP_066356218.1	putative addiction module antidote protein	Antitoxin
BAU06_RS26380	5308461..5308760	-	300	WP_082988432.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BAU06_RS23270	5308937..5309497	+	561	WP_066356224.1	YdeI/OmpD-associated family protein	-
BAU06_RS23280	5310051..5310965	+	915	WP_066356226.1	c-type cytochrome	-
BAU06_RS23285	5311283..5312527	-	1245	WP_066356229.1	helix-turn-helix domain-containing protein	-
BAU06_RS23290	5312611..5313072	+	462	WP_066356231.1	helix-turn-helix domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (13-95)

Antitoxin

• Cro/C1-type helix-turn-helix domain (49-93)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11102.90 Da
• Isoelectric Point: 10.5793

>T64276 WP_082988432.1 NZ_CP016170:c5308760-5308461 [Bordetella bronchialis]
MAYIVKLLPGFSDWLKGLKDPVTRQRLVKRLDKARLGNLGEVKPVGNGVSEMREDFGPGWRMYYVQRGNTVVVMLAGGNK
RSQQADIRRAIALAESLED

Nucleotide

• Length: 300 bp

>T64276 NZ_CP016170:c5308760-5308461 [Bordetella bronchialis]
ATGGCCTACATCGTAAAACTTCTCCCCGGATTCTCCGACTGGCTCAAAGGTCTCAAGGATCCCGTAACCCGGCAACGCTT
GGTCAAGCGCCTTGATAAGGCTCGATTGGGAAACCTGGGAGAGGTGAAGCCTGTAGGGAATGGCGTCTCTGAAATGCGAG
AAGACTTCGGCCCCGGGTGGCGCATGTATTACGTTCAGCGCGGCAATACCGTAGTAGTGATGCTGGCCGGTGGGAACAAG
CGAAGCCAACAAGCCGATATTCGACGCGCAATCGCGCTTGCCGAGTCTTTGGAGGACTGA

Antitoxin

Protein

• Length: 103 a.a.
• Molecular weight: 10969.55 Da
• Isoelectric Point: 4.8358

>AT64276 WP_066356218.1 NZ_CP016170:c5308457-5308149 [Bordetella bronchialis]
MTKNKISELPEFDAAEFLNSEEDIAAYLTTVLEDDDPALLAVALGNIARARGMTQVAKDAGIAREALYKALRPGSDPRFE
TISRVCAALGVRLVAQPKSLAH

Nucleotide

• Length: 309 bp

>AT64276 NZ_CP016170:c5308457-5308149 [Bordetella bronchialis]
ATGACCAAAAATAAGATTTCCGAGCTTCCTGAATTCGACGCAGCTGAATTCTTGAATAGCGAAGAAGACATAGCCGCGTA
CCTGACAACCGTGCTGGAAGATGACGATCCAGCGCTTCTTGCGGTCGCTCTCGGTAACATTGCGCGCGCCCGGGGGATGA
CTCAGGTGGCGAAAGACGCCGGTATCGCGCGGGAAGCTTTGTACAAGGCGCTGCGTCCTGGTAGCGATCCGCGGTTTGAA
ACGATTAGCCGCGTATGCGCGGCGTTGGGAGTGCGCCTGGTGGCGCAACCGAAAAGCCTGGCACACTGA

Structures

Antitoxin

• AlphaFold DB: A0A193G433