Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-MazE
Location 2987020..2987567 Replicon chromosome
Accession NZ_CP016170
Organism Bordetella bronchialis strain AU3182

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag BAU06_RS13225 Protein ID WP_197509530.1
Coordinates 2987020..2987346 (-) Length 109 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag BAU06_RS13230 Protein ID WP_066349781.1
Coordinates 2987343..2987567 (-) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BAU06_RS13205 2982904..2984268 + 1365 WP_066349776.1 allantoinase AllB -
BAU06_RS13210 2984261..2985610 + 1350 WP_066349777.1 MmgE/PrpD family protein -
BAU06_RS26180 2985879..2986808 + 930 WP_066349778.1 LysR family transcriptional regulator -
BAU06_RS13225 2987020..2987346 - 327 WP_197509530.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
BAU06_RS13230 2987343..2987567 - 225 WP_066349781.1 antitoxin MazE family protein Antitoxin
BAU06_RS13235 2987679..2988887 - 1209 WP_066349782.1 MFS transporter -
BAU06_RS13240 2988887..2989603 - 717 WP_066349783.1 arsenical resistance protein ArsH -
BAU06_RS13245 2989755..2990249 - 495 WP_066349784.1 arsenate reductase ArsC -
BAU06_RS26185 2990351..2990677 - 327 WP_082988199.1 metalloregulator ArsR/SmtB family transcription factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-105)

Antitoxin

Antitoxin MazE-like

(8-72)


Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 11749.91 Da        Isoelectric Point: 10.1863

>T64275 WP_197509530.1 NZ_CP016170:c2987346-2987020 [Bordetella bronchialis]
MMRGDLVTVAVQGDFGKLRPALVIQSDLLSEHGSVTVLPVTSSLVEAPLLRVMAKPSLQNRLRQPSQIMVDKAVTVRRDK
LGAAFGRIEPETLVEVERCLAVFLGIAK

Download         Length: 327 bp

>T64275 NZ_CP016170:c2987346-2987020 [Bordetella bronchialis]
CTGATGCGAGGTGATCTGGTAACCGTCGCTGTCCAAGGGGATTTTGGAAAGCTTCGTCCCGCGTTGGTGATCCAGTCGGA
CCTGCTCAGCGAACATGGCAGTGTGACGGTCCTTCCGGTAACCAGCAGTCTGGTCGAAGCGCCGCTGCTGCGAGTAATGG
CGAAACCTAGCCTGCAGAACCGCCTGCGGCAACCTTCCCAAATTATGGTGGACAAAGCCGTCACCGTAAGGCGTGACAAG
CTCGGCGCGGCTTTCGGTCGTATCGAGCCGGAAACCCTCGTCGAGGTCGAACGGTGCCTGGCGGTCTTTCTTGGAATCGC
CAAGTAG

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8465.46 Da        Isoelectric Point: 6.9791

>AT64275 WP_066349781.1 NZ_CP016170:c2987567-2987343 [Bordetella bronchialis]
MPGSNVNARVNKHRAALRMAGLRPVQIWVPDTRRPNFAEECRRQSVLASRDDSRDDDMQRLMDQAVSEVDGWDA

Download         Length: 225 bp

>AT64275 NZ_CP016170:c2987567-2987343 [Bordetella bronchialis]
ATGCCGGGAAGCAACGTTAACGCCCGTGTGAATAAGCACCGTGCGGCTTTGCGCATGGCAGGGCTGCGGCCGGTGCAAAT
CTGGGTACCCGATACGCGCCGGCCGAATTTCGCCGAGGAATGCCGTCGCCAATCCGTCTTGGCAAGCCGTGACGATTCAA
GGGACGACGATATGCAGCGGCTGATGGACCAGGCCGTGTCCGAGGTAGACGGCTGGGATGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References