Detailed information of TA system TA064273

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VapB
• Location: 937020..937585
• Replicon: chromosome
• Accession: NZ_CP016170
• Organism: Bordetella bronchialis strain AU3182

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: BAU06_RS04105
• Protein ID: WP_066344637.1
• Coordinates: 937020..937391 (-)
• Length: 124 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: BAU06_RS04110
• Protein ID: WP_066344638.1
• Coordinates: 937388..937585 (-)
• Length: 66 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BAU06_RS04085	932719..933435	-	717	WP_066344629.1	ABC transporter permease	-
BAU06_RS04090	933841..935499	-	1659	WP_066344630.1	ATP-binding domain-containing protein	-
BAU06_RS04095	935698..936615	+	918	WP_066344632.1	glutathione-dependent disulfide-bond oxidoreductase	-
BAU06_RS04100	936612..936986	+	375	WP_066344636.1	DOPA 4,5-dioxygenase family protein	-
BAU06_RS04105	937020..937391	-	372	WP_066344637.1	type II toxin-antitoxin system VapC family toxin	Toxin
BAU06_RS04110	937388..937585	-	198	WP_066344638.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
BAU06_RS04115	937861..938382	+	522	WP_066344640.1	sigma-70 family RNA polymerase sigma factor	-
BAU06_RS04120	938379..939407	+	1029	WP_066344642.1	FecR family protein	-
BAU06_RS04125	939507..941948	+	2442	WP_197509430.1	TonB-dependent receptor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-112)

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (1-44)

Sequences

Toxin

Protein

• Length: 124 a.a.
• Molecular weight: 13349.39 Da
• Isoelectric Point: 4.8134

>T64273 WP_066344637.1 NZ_CP016170:c937391-937020 [Bordetella bronchialis]
MILVDTSVWIDHLNASEPLLASLLADGQVLVHPFVIAEIALGSVKDREAVLGALRDLPNALVATPQETLFLIEREGLYNR
GIGYVDTSLLASARLQPGTTVWTRDKRLARAADELGLSPNLLH

Nucleotide

• Length: 372 bp

>T64273 NZ_CP016170:c937391-937020 [Bordetella bronchialis]
ATGATCCTGGTCGATACGTCGGTTTGGATCGACCACCTCAATGCGTCCGAACCGCTATTGGCCAGCCTGCTGGCGGACGG
ACAAGTGCTCGTACACCCTTTTGTGATCGCCGAGATCGCCCTGGGGAGCGTGAAAGACCGCGAGGCCGTACTTGGCGCAT
TGCGCGATCTGCCCAACGCGCTCGTTGCGACGCCCCAGGAAACGCTGTTCCTCATCGAGCGCGAAGGGCTGTACAACCGC
GGCATCGGTTACGTAGACACATCTTTGCTGGCCTCCGCGCGATTGCAGCCGGGCACAACGGTATGGACGCGGGACAAAAG
GCTGGCGCGGGCTGCCGACGAACTCGGACTAAGCCCGAACCTGTTGCATTAG

Antitoxin

Protein

• Length: 66 a.a.
• Molecular weight: 7105.21 Da
• Isoelectric Point: 9.9948

>AT64273 WP_066344638.1 NZ_CP016170:c937585-937388 [Bordetella bronchialis]
MRTTIALDDDLLAKAQAYTGVQEKSALVREALKALIQREAAKRLIALGGSQPGMEAAPRRRQDLE

Nucleotide

• Length: 198 bp

>AT64273 NZ_CP016170:c937585-937388 [Bordetella bronchialis]
ATGCGAACTACGATCGCGCTCGATGATGATTTACTGGCCAAGGCGCAGGCCTATACAGGTGTCCAGGAGAAATCGGCGCT
GGTGCGTGAAGCACTGAAGGCACTGATCCAGCGCGAAGCGGCCAAGCGGCTCATCGCCCTGGGCGGAAGCCAGCCCGGCA
TGGAAGCGGCTCCGCGCCGGCGGCAGGACCTGGAATGA