Detailed information of TA system TA064264

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Acetyltransf_4(toxin)
• Location: 3816014..3817416
• Replicon: chromosome
• Accession: NZ_CP016162
• Organism: Pseudomonas alcaliphila JAB1

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: UYA_RS17735
• Protein ID: WP_075749135.1
• Coordinates: 3816847..3817416 (-)
• Length: 190 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: A0A0Q4S4P8
• Locus tag: UYA_RS17730
• Protein ID: WP_017675065.1
• Coordinates: 3816014..3816841 (-)
• Length: 276 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
UYA_RS17715	3812919..3813824	-	906	WP_075749131.1	hypothetical protein	-
UYA_RS17720	3813835..3814407	-	573	WP_074917075.1	LemA family protein	-
UYA_RS17725	3814598..3815935	+	1338	WP_075749133.1	peptidase	-
UYA_RS17730	3816014..3816841	-	828	WP_017675065.1	AraC family transcriptional regulator	Antitoxin
UYA_RS17735	3816847..3817416	-	570	WP_075749135.1	GNAT family N-acetyltransferase	Toxin
UYA_RS17740	3817633..3821121	+	3489	WP_075749137.1	hybrid sensor histidine kinase/response regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (14-146)

Antitoxin

• DNA binding HTH domain, AraC-type (193-270)

Sequences

Toxin

Protein

• Length: 190 a.a.
• Molecular weight: 21410.59 Da
• Isoelectric Point: 7.3594

>T64264 WP_075749135.1 NZ_CP016162:c3817416-3816847 [Pseudomonas alcaliphila JAB1]
MFKPQLVTLQRGALRLEPLSDADIPALVALAEANREELLYMSGTQRLDWYRSALADMREQRALPFVIRLGDELVGTTRFA
DFMNTLPACEIGWTWLDHNQHGSGLNTSIKYLMLKHAFENWGMVRVQLKTAASNLRSQRAIEKLGAVREGLLRNHRRLAD
GRLDDTVLYSITDLEWPALRGAMEAGFNA

Nucleotide

• Length: 570 bp

>T64264 NZ_CP016162:c3817416-3816847 [Pseudomonas alcaliphila JAB1]
ATGTTCAAGCCGCAGCTGGTGACTTTGCAACGTGGCGCTCTGCGCCTGGAACCGCTCTCTGACGCCGATATCCCCGCGCT
GGTGGCGCTGGCCGAAGCCAATCGCGAGGAGCTGCTGTACATGAGCGGCACCCAGCGACTGGACTGGTACCGCAGCGCCC
TGGCCGATATGCGCGAGCAGCGGGCACTGCCGTTCGTCATTCGTCTGGGTGACGAGTTGGTAGGCACCACCCGCTTCGCC
GACTTCATGAACACCCTGCCGGCCTGTGAAATCGGCTGGACCTGGCTCGACCACAACCAGCATGGCAGCGGGTTGAACAC
CAGCATCAAGTACTTGATGCTCAAGCACGCTTTCGAAAATTGGGGCATGGTTCGCGTGCAACTGAAAACCGCCGCCAGCA
ACCTGCGTTCGCAACGCGCCATCGAGAAGCTTGGCGCCGTTCGTGAAGGGTTGCTGCGCAACCATCGCCGTCTGGCCGAT
GGCCGACTCGATGACACCGTGCTGTACAGCATCACGGATCTGGAATGGCCGGCGCTGCGTGGGGCAATGGAGGCGGGCTT
CAACGCCTGA

Antitoxin

Protein

• Length: 276 a.a.
• Molecular weight: 30764.16 Da
• Isoelectric Point: 8.7310

>AT64264 WP_017675065.1 NZ_CP016162:c3816841-3816014 [Pseudomonas alcaliphila JAB1]
MHSREQTRFWQASALSGVELLQARYLEQRFAPHVHEGFVFTVIEHGAQRFRHRGCDHLAPQGSMVLINPDEVHTGSKAHE
DGWRYRGFYPDNAQVLGALQELGLAKAGMPSFAFSVLHDPRLHAAFLQLHQLLEGGAEALQQQLAWREAILLLFQHHAQL
AEPPAPGREPWAVACAKQMLAERLIEPPSLEELAAAVNLSPFHFARVFRRATGLPPHAWLKQRRLEQARALLKTGCTAVA
VAMQLGFADQSHLSRQFKQVYGVSPGEYRSAVARS

Nucleotide

• Length: 828 bp

>AT64264 NZ_CP016162:c3816841-3816014 [Pseudomonas alcaliphila JAB1]
ATGCACAGTCGCGAGCAGACCCGCTTCTGGCAAGCTTCCGCATTGAGCGGCGTCGAGCTGTTGCAGGCGCGCTACCTTGA
ACAGCGCTTCGCGCCCCACGTGCATGAAGGTTTCGTGTTCACCGTGATCGAGCATGGCGCCCAGCGCTTTCGTCATCGCG
GTTGTGATCATCTGGCCCCACAGGGCAGCATGGTGCTGATCAACCCGGACGAAGTGCACACCGGCTCCAAGGCGCACGAG
GACGGTTGGCGCTATCGCGGTTTCTATCCCGATAACGCCCAGGTATTGGGGGCGCTGCAGGAGCTGGGCCTGGCCAAGGC
TGGCATGCCGTCGTTTGCCTTCAGCGTGCTGCATGATCCACGTTTGCATGCGGCCTTTCTGCAACTGCACCAACTGCTCG
AGGGTGGTGCCGAGGCACTGCAGCAGCAACTGGCCTGGCGTGAGGCGATTCTGCTGCTGTTTCAGCATCATGCGCAGCTT
GCCGAACCACCTGCGCCTGGGCGTGAGCCCTGGGCCGTGGCTTGTGCCAAGCAGATGCTCGCCGAGCGGCTGATCGAGCC
GCCCTCGCTGGAGGAACTGGCGGCTGCGGTCAATCTTTCACCGTTTCATTTCGCTCGAGTGTTCCGCCGCGCGACCGGCT
TGCCACCGCATGCCTGGCTCAAGCAGCGGCGCCTGGAGCAGGCGCGGGCGTTGCTCAAGACGGGCTGCACGGCGGTCGCT
GTGGCCATGCAGTTGGGCTTCGCCGATCAGAGCCACTTGTCGCGACAGTTCAAGCAGGTTTATGGCGTGAGCCCTGGCGA
ATATCGCAGCGCGGTGGCCCGGAGCTGA

Structures

Antitoxin

• AlphaFold DB: A0A0Q4S4P8